Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Casey C. Lynch"'
Autor:
Sean Broce, Florian Ermini, Leslie J. Holsinger, Stephen S. Dominy, Michael J. Detke, Leo Rodriguez, Ursula Haditsch, Casey C. Lynch, D. David Hennings, Mai Nguyen, Jianhong Wang, Shirin Arastu-Kapur, Debasish Raha
Publikováno v:
SSRN Electronic Journal.
Gingipains are protease virulence factors from the periodontal bacterial pathogen Porphyromonas gingivalis and were recently identified in greater than 90% of Alzheimer’s disease (AD) brains. Studies in wild-type mice and rats have demonstrated tha
Autor:
Mai Nguyen, Leo Rodriguez, Florian Ermini, Sean Broce, Mike Detke, Ursula Haditsch, Steve Dominy, Debasish Raha, Sandy Hancock, Leslie J. Holsinger, Casey C. Lynch, Thomas E. Cecere, Theresa Roth, Shirin Kapur
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Debasish Raha, Steve Dominy, Ursula Haditsch, Shirin Kapur, Casey C. Lynch, Sean Broce, Theresa Roth, Leo Rodriguez, Dave Hennings, Florian Ermini, Mike Detke, Mai Nguyen, Leslie J. Holsinger
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Florian Ermini, Debasish Raha, Mai Nguyen, Leslie J. Holsinger, Casey C. Lynch, Mark I. Ryder, Stephen S. Dominy, Ines A. M. De Lannoy, Ursula Haditsch, Joseph Araujo, Shirin Arastu-Kapur
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology research & perspectives, vol 8, iss 1
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Pharmacology research & perspectives, vol 8, iss 1
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
COR388, a small‐molecule lysine‐gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease. Gingipains are produced by two species of bacteria,
Autor:
Florian Ermini, Samer Kaba, Jan Potempa, Christina Griffin, Stephen S. Dominy, Malgorzata Benedyk, Debasish Raha, Agata Marczyk, Glenn D Walker, Casey C. Lynch, Mai Nguyen, Piotr Mydel, Annelie Hellvard, Eric C. Reynolds, Hatice Hasturk, Ursula Haditsch, Andrei Konradi, Maurice A. Curtis, Richard L.M. Faull, Leslie J. Holsinger, Mark I. Ryder, Karina Adamowicz, Mike Dragunow, Barbara Potempa, Shirin Arastu-Kapur, Alexander Lee
Publikováno v:
Science advances, vol 5, iss 1
Science Advances
Science Advances
Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors.
Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s dise
Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883a50af9b4a731c268d542b0ea8cca6
https://ruj.uj.edu.pl/xmlui/handle/item/80007
https://ruj.uj.edu.pl/xmlui/handle/item/80007
Autor:
Ira J. Goodman, Mark I. Ryder, Stephen G. Thein, Ursula Haditsch, Mike Detke, Dave Hennings, Leslie J. Holsinger, Shirin Kapur, Steve Dominy, Casey C. Lynch, Florian Ermini, Debasish Raha
Publikováno v:
Alzheimer's & Dementia. 15:P1585-P1585
Autor:
William C. Mobley, Stephen J. DeArmond, Casey C. Lynch, Chin-shiou Huang, Judith Klumperman, Andrew K. Feng, Jie Zhou
Publikováno v:
Journal of Biological Chemistry. 274:36707-36714
Nerve growth factor (NGF) binding to its receptors TrkA and p75(NTR) enhances the survival, differentiation, and maintenance of neurons. Recent studies have suggested that NGF receptor activation may occur in caveolae or caveolae-like membranes (CLM)
Autor:
Casey C. Lynch, William C. Mobley
Publikováno v:
Annals of the New York Academy of Sciences. 924
Neurotrophic factors (NTFs), once known for their role in development, have recently been shown to contribute to the maintenance and plasticity of the adult nervous system. This knowledge has provoked hypotheses implicating NTFs in neurodegenerative
Autor:
Arastu-Kapur S; Cortexyme, Inc., South San Francisco, CA, USA., Nguyen M; Cortexyme, Inc., South San Francisco, CA, USA., Raha D; Cortexyme, Inc., South San Francisco, CA, USA., Ermini F; Cortexyme, Inc., South San Francisco, CA, USA., Haditsch U; Cortexyme, Inc., South San Francisco, CA, USA., Araujo J; InterVivo Solutions, Toronto, ON, Canada., De Lannoy IAM; InterVivo Solutions, Toronto, ON, Canada., Ryder MI; University of California San Francisco, San Francisco, CA, USA., Dominy SS; Cortexyme, Inc., South San Francisco, CA, USA., Lynch C; Cortexyme, Inc., South San Francisco, CA, USA., Holsinger LJ; Cortexyme, Inc., South San Francisco, CA, USA.
Publikováno v:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2020 Feb; Vol. 8 (1), pp. e00562.
Autor:
Dominy SS; Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA., Lynch C; Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA., Ermini F; Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA., Benedyk M; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.; Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland., Marczyk A; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland., Konradi A; Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA., Nguyen M; Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA., Haditsch U; Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA., Raha D; Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA., Griffin C; Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA., Holsinger LJ; Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA., Arastu-Kapur S; Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA., Kaba S; Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA., Lee A; Cortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA., Ryder MI; Division of Periodontology, Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA., Potempa B; Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA., Mydel P; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.; Broegelman Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway., Hellvard A; Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.; Broegelman Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway., Adamowicz K; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland., Hasturk H; The Forsyth Institute, Cambridge, MA, USA.; Harvard University School of Dental Medicine, Boston, MA, USA., Walker GD; Cooperative Research Centre for Oral Health Science, Melbourne Dental School and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Melbourne, Victoria, Australia., Reynolds EC; Cooperative Research Centre for Oral Health Science, Melbourne Dental School and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Melbourne, Victoria, Australia., Faull RLM; Department of Anatomy with Radiology, Centre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Curtis MA; Centre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Dragunow M; Centre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Department of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Potempa J; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.; Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA.
Publikováno v:
Science advances [Sci Adv] 2019 Jan 23; Vol. 5 (1), pp. eaau3333. Date of Electronic Publication: 2019 Jan 23 (Print Publication: 2019).