1516 Advancing immunotherapy through patient-identified regulators of T cell stemness

Autor: Peter Jones, Xin Lan, Stephen Baylin, Caitlin Zebley, Tae Gun Kang, Tian Mi, Shanta Alli, Grace Ward, Anoop Babu Vasandan, Shala Carson, Kristen Groenbæk, Casey O’Connell, Benjamin Youngblood

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)

Externí odkaz: https://doaj.org/article/4995e67c99c042a9b064301f1f83e019

Efficacy and Safety of Add-on Parsaclisib to Ruxolitinib Therapy in Myelofibrosis Patients With Suboptimal Response to Ruxolitinib: Final Results From a Phase 2 Study

Autor: Abdulraheem Yacoub, Uma Borate, Raajit K Rampal, Haris Ali, Eunice Wang, Aaron T. Gerds, Gabriela S. Hobbs, Marina Kremyanskaya, Elliott Winton, Casey O'Connell, Swati Goel, Stephen T Oh, Gary J. Schiller, Albert Assad, Sue Erickson-Viitanen, Feng Zhou, Naval Daver

Publikováno v: Blood. 140:579-582

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39ad9445dab952b350b044ff0d662bfd
https://doi.org/10.1182/blood-2022-160384

Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM):results from an international, double-blind, randomised, controlled, phase 3 study

Autor: Srdan Verstovsek, Aaron T Gerds, Alessandro M Vannucchi, Haifa Kathrin Al-Ali, David Lavie, Andrew T Kuykendall, Sebastian Grosicki, Alessandra Iurlo, Yeow Tee Goh, Mihaela C Lazaroiu, Miklos Egyed, Maria Laura Fox, Donal McLornan, Andrew Perkins, Sung-Soo Yoon, Vikas Gupta, Jean-Jacques Kiladjian, Nikki Granacher, Sung-Eun Lee, Luminita Ocroteala, Francesco Passamonti, Claire N Harrison, Barbara J Klencke, Sunhee Ro, Rafe Donahue, Jun Kawashima, Ruben Mesa, Adi Shacham Abulafia, Bjorn Andreasson, Anna Angona, Rosa Ayala, Soo-Mee Bang, Bruce Bank, Fiorenza Barraco, Eloise Beggiato, Fleur Samantha Benghiat, MassimiliaNo Bonifacio, Claire Bories, Gabriela Borsaru, Mette Brabrand, Andrei Braester, Andes Broliden, Veronika Buxhofer-Ausch, Nathalie Cambier, Marianna Caramella, Benjamin Carpentier, Nicola Cascavilla, Maria Giraldo Castellano, Hung Chang, Chih-Cheng Chen, June-Won Cheong, Yunsuk Choi, Philip Choi, Maria Teresa Corsetti, Isabel Montero Cuadrado, Julia Cunningham, Gandhi Laurent Damaj, Valerio De Stefano, Robert Delage, Regina Garcĺa Delgado, Jose Miguel Torregrosa Diaz, Péter Dombi, Viviane Dubruille, Miklós Egyed, Daniel El Fassi, Anna Elinder-Camburn, Elena Maria Elli, Martin Ellis, Carmen Fava, Salman Fazal, Angela Fleischman, Lynda Foltz, Laura Fox, Nashat Gabrail, Jose Valentĺn Garcĺa-Gutiérrez, Aaron Gerds, Stephane Girault, Heinz Gisslinger, Alexandru Gluvacov, Joachim Göthert, Evgeni (Evgueniy) Hadjiev (Hadzhiev), Kaoutar Hafraoui, Aryan Hamed, Claire Harrison, Hans Hasselbalch, Hanns Hauser, Mark Heaney, Holger Hebart, Jesus Maria Hernandez Rivas, Victor Higuero Saavedra, Christopher Hillis, Hsin-An Hou, Jonathan How, Daniel Huang, Marek Hus, Arpad Illés, Alessandro Isidori, Vadim Ivanov, Peter Johansson, Chul Won Jung, Ilya Kirgner, Maya Koren-Michowitz, Steffen Koschmieder, Szabolcs Ors Kosztolanyi, Natalia Kreiniz, Andrew Kuykendall, Jonathan Lambert, Kamel Laribi, Axelle Lascaux, Noa Lavie, Mihaela Lazaroiu, Michael Leahy, Ewa Lech-Maranda, Won Sik Lee, Ollivier Legrand, Roberto Lemoli, James Liang, Sung-Nam Lim, Michael Loschi, Alessandro Lucchesi, Ioan Macarie, Jean-Pierre Marolleau, Maurizio Martelli, Jiri Mayer, James McCloskey, Christopher McDermott, Brandon McMahon, Priyanka Mehta, Gábor Mikala, Dragana Milojkovic, Philippe Mineur, Elena Mishchenko, Joon Ho Moon, Zsolt Nagy, Srinivasan Narayanan, Casey O'Connell, Stephen Oh, Mario Ojeda-Uribe, Kiat Hoe Ong, Folashade Otegbeye, Jeanne Palmer, Fabrizio Pane, Andrea Patriarca, Giuseppe Pietrantuono, Mark Plander, Uwe Platzbecker, Ritam Prasad, Witold Prejzner, Tobias Rachow, Atanas Radinoff, László Rejtő, Ciro Rinaldi, Tadeusz Robak, Maria Angeles Fernandez Rodriguez, Aaron Ronson, David Ross, Tomasz Sacha, Parvis Sadjadian, Antonio Salar, Guillermo Sanz Santillana, Christof Scheid, Aline Schmidt, Marianne Tang Severinsen, Vera Stoeva, Paweł Szwedyk, Mario Tiribelli, Karolin Trautmann-Grill, Amy Trottier, Nikolay Tzvetkov, Janusz van Droogenbroeck, Alessandro Vannucchi, Nicola Vianelli, Nikolas von Bubnoff, Dominik Wolf, Dariusz Woszczyk, Tomasz Woźny, Tomasz Wróbel, Blanca Xicoy, Su-Peng Yeh

Publikováno v: Verstovsek, S, Gerds, A, Vannucchi, A, Vannucchi, A, Al-Ali, H K, Lavie, D, Kuykendall, A T, Grosicki, S, Iurlo, A, Goh, Y T, Lazaroiu, M C, Egyed, M, Fox, M L, McLornan, D, Harrison, C N, Perkins, A, Yoon, S S, Gupta, V, Kiladjian, J J, Granacher, N, Lee, S E, Ocroteala, L, Passamonti, F, Klencke, B J, Ro, S, Donahue, R, Kawashima, J, Mesa, R, MOMENTUM Study Investigators & Severinsen, M T 2023, ' Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM) : results from an international, double-blind, randomised, controlled, phase 3 study ', The Lancet, vol. 401, no. 10373, pp. 269-280 . https://doi.org/10.1016/S0140-6736(22)02036-0

BACKGROUND: Janus kinase (JAK) inhibitors approved for myelofibrosis provide spleen and symptom improvements but do not meaningfully improve anaemia. Momelotinib, a first-in-class inhibitor of activin A receptor type 1 as well as JAK1 and JAK2, has s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0a29b32da77b75b50f0a41ca3581cd
https://vbn.aau.dk/da/publications/00e2be43-3d7e-42ce-a974-744fc61bd9e2

DNMT and EZH2 inhibitors synergize to activate therapeutic targets in hepatocellular carcinoma

Autor: Lian Zhang, Hong-Tao Li, Rachel Shereda, Qianjin Lu, Daniel J. Weisenberger, Casey O'Connell, Keigo Machida, Woojin An, Heinz-Josef Lenz, Anthony El-Khoueiry, Peter A. Jones, Minmin Liu, Gangning Liang

Publikováno v: Cancer letters. 548

The development of more effective targeted therapies for hepatocellular carcinoma (HCC) patients due to its aggressiveness is urgently needed. DNA methyltransferase inhibitors (DNMTis) represented the first clinical breakthrough to target aberrant ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb481c127fd8f01677296d8e1322dd3
https://pubmed.ncbi.nlm.nih.gov/36087682

Persistent leukocytosis in polycythemia vera is associated with disease evolution but not thrombosis

Autor: Lukas Ronner, Angela G. Fleischman, Ruben A. Mesa, Matthew Chiaramonte, John Mascarenhas, Jason Gotlib, Revathi Kollipara, Mark L. Heaney, Mahta Salehi, Jenny Nguyen, Megan Randall, Cecelia Perkins, Douglas Tremblay, Robyn M. Scherber, Olivia Siwoski, Casey O'Connell, Nikolai A. Podoltsev, Annie Kwok Hung, Lindsey Behlman, Kimia Ziadkhanpour, Andrew T. Kuykendall, Shelby Meckstroth, Ami Dave, Erin Moshier, Jamile M. Shammo, Ronald Hoffman, Michelle Janania Martinez, Mitchell Harrison, Sagar Patel, Paola Fernandez Soto, Michael P. Grant, Hellen Nguyen, Abdulraheem Yacoub

Publikováno v: Blood. 135:1696-1703

There are unresolved questions regarding the association between persistent leukocytosis and risk of thrombosis and disease evolution in polycythemia vera (PV), as much of the published literature on the topic does not appropriately use repeated-meas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c52862302a480a9fb967c12f777312e
https://doi.org/10.1182/blood.2019003347