Impaired polyamine metabolism causes behavioral and neuroanatomical defects in a mouse model of Snyder-Robinson syndrome.

Autor: Akinyele O; Division of Genetic and Genomic Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA., Munir A; Division of Genetic and Genomic Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.; Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA., Johnson MA; Division of Genetic and Genomic Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA., Perez MS; Division of Genetic and Genomic Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.; Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA., Gao Y; Children's Neuroscience Institute, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA., Foley JR; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA., Nwafor A; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA., Wu Y; Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA., Murray-Stewart T; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA., Casero RA Jr; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA., Bayir H; Children's Neuroscience Institute, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA., Kemaladewi DU; Division of Genetic and Genomic Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.; Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Children's Neuroscience Institute, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.

Publikováno v: Disease models & mechanisms [Dis Model Mech] 2024 Jun 01; Vol. 17 (6). Date of Electronic Publication: 2024 May 09.

Polyamines: the pivotal amines in influencing the tumor microenvironment.

Autor: Holbert CE; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Casero RA Jr; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Stewart TM; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA. tmurray2@jh.edu.

Publikováno v: Discover oncology [Discov Oncol] 2024 May 18; Vol. 15 (1), pp. 173. Date of Electronic Publication: 2024 May 18.

Polyamine Catabolism and Its Role in Renal Injury and Fibrosis in Mice Subjected to Repeated Low-Dose Cisplatin Treatment.

Autor: Zahedi K; Division of Nephrology, Department of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.; Research Services, New Mexico Veterans Health Care Center, Albuquerque, NM 87108, USA., Barone S; Division of Nephrology, Department of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.; Research Services, New Mexico Veterans Health Care Center, Albuquerque, NM 87108, USA., Brooks M; Division of Nephrology, Department of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.; Research Services, New Mexico Veterans Health Care Center, Albuquerque, NM 87108, USA., Stewart TM; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Foley JR; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Nwafor A; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Casero RA Jr; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Soleimani M; Division of Nephrology, Department of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.; Research Services, New Mexico Veterans Health Care Center, Albuquerque, NM 87108, USA.

Publikováno v: Biomedicines [Biomedicines] 2024 Mar 13; Vol. 12 (3). Date of Electronic Publication: 2024 Mar 13.

Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.

Autor: Padgett LR; Indiana Biosciences Research Institute, Indianapolis, IN 46202, USA., Shinkle MR; Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA., Rosario S; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA., Stewart TM; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Foley JR; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Casero RA Jr; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA., Park MH; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4340, USA., Chung WK; Departments of Pediatrics and Medicine, Columbia University, New York, NY 10032, USA., Mastracci TL; Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Publikováno v: HGG advances [HGG Adv] 2023 May 18; Vol. 4 (3), pp. 100206. Date of Electronic Publication: 2023 May 18 (Print Publication: 2023).

Functional assessment of homozygous ALDH18A1 variants reveals alterations in amino acid and antioxidant metabolism.

Autor: Colonna MB; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA., Moss T; Greenwood Genetic Center, Greenwood, SC 29646, USA., Mokashi S; Greenwood Genetic Center, Greenwood, SC 29646, USA., Srikanth S; Greenwood Genetic Center, Greenwood, SC 29646, USA., Jones JR; Greenwood Genetic Center, Greenwood, SC 29646, USA., Foley JR; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine; Baltimore, MD 21287, USA., Skinner C; Greenwood Genetic Center, Greenwood, SC 29646, USA., Lichty A; Greenwood Genetic Center, Greenwood, SC 29646, USA., Kocur A; Greenwood Genetic Center, Greenwood, SC 29646, USA., Wood T; Department of Pathology and Laboratory Medicine, Children's Hospital Colorado, Aurora, CO 80045, USA., Stewart TM; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine; Baltimore, MD 21287, USA., Casero RA Jr; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine; Baltimore, MD 21287, USA., Flanagan-Steet H; Greenwood Genetic Center, Greenwood, SC 29646, USA., Edison AS; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA., Lyons MJ; Greenwood Genetic Center, Greenwood, SC 29646, USA., Steet R; Greenwood Genetic Center, Greenwood, SC 29646, USA.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2023 Feb 19; Vol. 32 (5), pp. 732-744.