Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site-directed mutagenesis

Autor: Caseley, EA, Muench, SP, Jiang, L-H

The P2X7 receptor (P2X7R) is a calcium-permeable cation channel activated by high concentrations of extracellular ATP. It plays a role in vital physiological processes, particularly in innate immunity, and is dysregulated in pathological conditions s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ea6f12878f679cf5ad472da9f1b3886d

Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy.

Autor: Hussain R; Epilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia., Lim CX; Epilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.; Pharmacy, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, 3083, Australia., Shaukat Z; Epilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia., Islam A; Epilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.; College of Medicine and Public Health, Flinders University, Bedford Park, SA, 5042, Australia., Caseley EA; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Lippiat JD; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK., Rychkov GY; Epilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia.; School of Biomedicine, University of Adelaide, Adelaide, SA, 5005, Australia.; South Australian Health and Medical Research Institute, Adelaide, SA, 5005, Australia., Ricos MG; Epilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia., Dibbens LM; Epilepsy Research Group, Clinical and Health Sciences, Australian Centre for Precision Health, University of South Australia, Adelaide, SA, 5000, Australia. Leanne.Dibbens@unisa.edu.au.

Publikováno v: Scientific reports [Sci Rep] 2024 Feb 09; Vol. 14 (1), pp. 3357. Date of Electronic Publication: 2024 Feb 09.

Inflammasome activation: from molecular mechanisms to autoinflammation.

Autor: Lara-Reyna S; Institute of Microbiology and Infection University of Birmingham Birmingham UK., Caseley EA; School of Biomedical Sciences, Faculty of Biological Sciences University of Leeds Leeds UK., Topping J; Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital University of Leeds Leeds UK., Rodrigues F; AP-HP, Hôpital Tenon, Sorbonne Université, Service de Médecine interne Centre de Référence des Maladies Auto-inflammatoires et des Amyloses d'origine inflammatoire (CEREMAIA) Paris France., Jimenez Macias J; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA.; Brown Cancer Centre, Department of Pathology and Laboratory Medicine Brown University Providence Rhode Island USA., Lawler SE; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA.; Brown Cancer Centre, Department of Pathology and Laboratory Medicine Brown University Providence Rhode Island USA., McDermott MF; Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital University of Leeds Leeds UK.

Publikováno v: Clinical & translational immunology [Clin Transl Immunology] 2022 Jul 07; Vol. 11 (7), pp. e1404. Date of Electronic Publication: 2022 Jul 07 (Print Publication: 2022).

An Atypical Autoinflammatory Disease Due to an LRR Domain NLRP3 Mutation Enhancing Binding to NEK7.

Autor: Caseley EA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital, Leeds, UK., Lara-Reyna S; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK., Poulter JA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital, Leeds, UK., Topping J; Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital, Leeds, UK., Carter C; Transplant and Cellular Immunology, St James's University Hospital, Leeds, UK., Nadat F; Transplant and Cellular Immunology, St James's University Hospital, Leeds, UK., Spickett GP; Regional Department of Immunology, Royal Victoria Infirmary, Newcastle Upon Tyne, UK., Savic S; Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital, Leeds, UK.; Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, UK.; National Institute for Health Research-Leeds Biomedical Research Centre, Chapel Allerton Hospital, Leeds, UK., McDermott MF; Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital, Leeds, UK. M.McDermott@leeds.ac.uk.

Publikováno v: Journal of clinical immunology [J Clin Immunol] 2022 Jan; Vol. 42 (1), pp. 158-170. Date of Electronic Publication: 2021 Oct 21.

Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptors.

Autor: Caseley EA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital, Faculty of Medicine and Health, Leeds, UK.; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 JT, UK., Muench SP; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 JT, UK., Jiang LH; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 JT, UK. l.h.jiang@leeds.ac.uk.

Publikováno v: Purinergic signalling [Purinergic Signal] 2020 Dec; Vol. 16 (4), pp. 485-490. Date of Electronic Publication: 2020 Oct 08.