Discontinuation versus continuation of hypertonic saline or dornase alfa in modulator treated people with cystic fibrosis (SIMPLIFY): results from two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials

Autor: Mayer-Hamblett, Nicole, Ratjen, Felix, Russell, Renee, Donaldson, Scott H, Riekert, Kristin A, Sawicki, Gregory S, Odem-Davis, Katherine, Young, Julia K, Rosenbluth, Daniel, Taylor-Cousar, Jennifer L, Goss, Christopher H, Retsch-Bogart, George, Clancy, John Paul, Genatossio, Alan, O'Sullivan, Brian P, Berlinski, Ariel, Millard, Susan L, Omlor, Gregory, Wyatt, Colby A, Moffett, Kathryn, Nichols, David P, Gifford, Alex H, Kloster, Margaret, Weaver, Katie, Chapdu, Claire, Xie, Jing, Skalland, Michelle, Romasco, Melita, Heltshe, Sonya, Simon, Noah, VanDalfsen, Jill, Mead, Anna, Buckingham, Rachael, Seidel, Kathy, Midamba, Nikita, Couture, Laurel, Case, Brooke Zappone, Au, Wendy, Rockers, Elsie, Cooke, Diane, Olander, Amber, Bondick, Irene, Johnson, Miya, VanHousen, Lisya, Nicholson, Boris, Omlor, Gregory, Parrish, Michelle, Roberts, Dion, Head, Jillian, Carey, Jessica, Caverly, Lindsay, Dangerfield, Joy, Linnemann, Rachel, Fullmer, Jason, Roman, Chelsea, Mogayzel, Peter, Reyes, Deanne, Harmala, Amy, Lysinger, Jerimiah, Bergeron, Jonathan, Virella-Lowell, Isabel, Brown, Perry, Godusevic, Lejla, Casey, Alicia, Paquette, Lauren, Lahiri, Thomas, Sweet, Julie, Donaldson, Scott, Harris, Joshua, Parnell, Shelia, Szentpetery, Sylvia, Froh, Deborah, Tharrington, Erica, Jain, Manu, Nelson, Rachel, Kadon, Sharon, McPhail, Gary, McBennett, Kimberly, Rone, Tia, Dasenbrook, Elliott, Weaver, Dave, Johnson, Terri, McCoy, Karen, Jain, Raksha, Mcleod, Maria, Klosterman, Mary, Sharma, Preeti, Jones, Amy, Mueller, Gary, Janney, Rachel, Taylor-Cousar, Jennifer, Cross, Mary, Hoppe, Jordana, Cahill, James, Mukadam, Zubin, Finto, Jill, Schultz, Karen, Villalta, Silvia Delgado, Smith, Alexa, Millard, Susan, Symington, Thomas, Graff, Gavin, Kitch, Diane, Sanders, Don, Thompson, Misty, Pena, Tahuanty, Teresi, Mary, Gafford, Jennifer, Schaeffer, David, Mermis, Joel, Scott, Lawrence, Escobar, Hugo, Williams, Kristen, Dorman, Dana, O'Sullivan, Brian, Bethay, Ryan, Danov, Zoran, Berlinski, Ariel, Turbeville, Kat, Johannes, Jimmy, Rodriguez, Angelica, Marra, Bridget, Zanni, Robert, Morton, Ronald, Simeon, Terri, Braun, Andrew, Dondlinger, Nicole, Biller, Julie, Hubertz, Erin, Antos, Nicholas, Roth, Laura, Billings, Joanne, Larson, Catherine, Balaji, Priya, McNamara, John, Clark, Tammy, Moffett, Kathryn, Griffith, Rebecca, Martinez, Nancy, Hussain, Sabiha, Malveaux, Halina, Egan, Marie, Guzman, Catalina, DeCelie-Germana, Joan, Galvin, Susan, Savant, Adrienne, Falgout, Nicole, Walker, Patricia, Demarco, Teresa, DiMango, Emily, Ycaza, Maria, Ballo, Julie, Tirakitsoontorn, Pornchai, Layish, Daniel, Serr, Desiree, Livingston, Floyd, Wooldridge, Sherry, Milla, Carlos, Spano, Jacquelyn, Davis, Rebecca, Elidemir, Okan, Chittivelu, Subramanyam, Scott, Ashley, Alam, Sarah, Dorgan, Daniel, Butoryak, Matt, Weiner, Daniel, Renna, Harmony, Wyatt, Colby, Klein, Brendan, Stone, Anne, Lessard, Meg, Schechter, Michael S., Johnson, Barbara, Scofield, Steven, Liou, Theodore, Vroom, Jane, Akong, Kathryn, Gil, Marissa, Betancourt, Legna, Singer, Jonathan, Ly, Ngoc, Moreno, Courtney, Aitken, Moira, Gambol, Teresa, Genatossio, Alan, Gibson, Ronald, Lambert, Allison, Milton, Joan, Rosenbluth, Daniel, Smith, Sarah, Green, Deanna, Hodge, Diana, Fortner, Christopher, Forell, Mary, Karlnoski, Rachel, Patel, Kapil, Daines, Cori, Ryan, Elizabeth, Amaro-Galvez, Rodolfo, Dohanich, Elizabeth, Lennox, Alison, Messer, Zachary, Hanes, Holly, Powell, Kay, Polineni, Deepika

Publikováno v: The Lancet Respiratory Medicine; April 2023, Vol. 11 Issue: 4 p329-340, 12p