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Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach

Publikováno v: ChemMedChem (Internet) (2012).
info:cnr-pdr/source/autori:Mugnaini C; Nocerino S; Pedani V; Pasquini S; Tafi A; De Chiaro M; Bellucci L; Valoti M; Guida F; Luongo L; Dragoni S; Ligresti A; Rosenberg A; Bolognini D; Cascio MG; Pertwee RG; Moaddel R; Maione S; Di Marzo V; Corelli F/titolo:Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach./doi:/rivista:ChemMedChem (Internet)/anno:2012/pagina_da:/pagina_a:/intervallo_pagine:/volume

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d9ae16c1dc07f1f8911ceaaa22806f7a
https://publications.cnr.it/doc/188571

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A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up

Autor: Cobellis G, Ricci G, Cacciola G, Orlando P, Petrosino S, Cascio MG, Bisogno T, De Petrocellis L, Chioccarelli T, Altucci L, Fasano S, Meccariello R, Pierantoni R, Ledent C, Di Marzo V.

Publikováno v: Biology of reproduction 82 (2010): 451–458. doi:10.1095/biolreprod.109.079210
info:cnr-pdr/source/autori:Cobellis G, Ricci G, Cacciola G, Orlando P, Petrosino S, Cascio MG, Bisogno T, De Petrocellis L, Chioccarelli T, Altucci L, Fasano S, Meccariello R, Pierantoni R, Ledent C, Di Marzo V./titolo:A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up./doi:10.1095%2Fbiolreprod.109.079210/rivista:Biology of reproduction/anno:2010/pagina_da:451/pagina_a:458/intervallo_pagine:451–458/volume:82

During transit through the epididymis, spermatozoa are normally kept immotile and do not attain the ability to become motile until they reach the caudal epididymis. This study was undertaken to determine whether endocannabinoids play a role in the ep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::eba6f6547d3078f469570fc3a9641637
http://hdl.handle.net/11591/193310

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In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB(2) receptor inverse agonists

Autor: CASCIO MG, BOLOGNINI D, PERTWEE RG, PALAZZO, Enza, CORELLI F, PASQUINI S, DI MARZO, V, MAIONE S.

Publikováno v: Pharmacological research. 61(4)

We have previously developed quinolone-3-carboxamides with the aim of obtaining new ligands for both cannabinoid receptors, CB1 and CB2. Our preliminary screening led to the identification of cannabinoid receptor ligands characterized by high affinit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a68ddf7a7e88abae1ce82aa02f5609
https://pubmed.ncbi.nlm.nih.gov/19961936

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In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands

Autor: CASCIO MG, BISOGNO T, PALAZZO, Enza, THOMAS A, VAN DER STELT M, BRIZZI A, DE NOVELLIS, Vito, NOVELLIS V, MARABESE, Ida, ROSS R, VAN DE DOELEN T, BRIZZI V, PERTWEE R, MAIONE, Sabatino, DI MARZO V.

We have previously reported the development of CB-25 and CB-52, two ligands of CB1 and CB2 cannabinoid receptors. We assessed here their functional activity.The effect of the two compounds on forskolin-induced cAMP formation in intact cells or GTP-ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::08acb14cdbefcc3da534e7d0467b6bc4
http://hdl.handle.net/11365/18520

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Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation

Autor: Bolognini, D, Rock, EM, Cluny, NL, Cascio, MG, Limebeer, CL, Duncan, M, Stott, CG, Javid, FA, Parker, LA, Pertwee, RG

To evaluate the ability of cannabidiolic acid (CBDA) to reduce nausea and vomiting and enhance 5-HT(1A) receptor activation in animal models.We investigated the effect of CBDA on (i) lithium chloride (LiCl)-induced conditioned gaping to a flavour (na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::84e7e5d660161958aa355f9d70cb133b
https://europepmc.org/articles/PMC3596650/

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The endocannabinoid system and the molecular basis of paralytic ileus in mice. FASEB J. 2002 Dec;

Autor: MASCOLO, NICOLA DOMENICO C. FERDINANDO, IZZO AA, LIGRESTI A, PINTO L, CASCIO MG, MAFFIA P, CECIO A, CAPASSO F, DI MARZO V., COSTAGLIOLA, ANNA

Epub 2002 Oct 18.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::be083d59ab2a22ce5d7952e6239e8800
http://hdl.handle.net/11588/137276

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Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors

Autor: Pasquini S, De Rosa M, Ligresti A, Mugnaini C, Brizzi A, Caradonna NP, Cascio MG, Bolognini D, Pertwee RG, Di Marzo V, Corelli F.

Publikováno v: European journal of medicinal chemistry (Online) (2012).
info:cnr-pdr/source/autori:Pasquini S, De Rosa M, Ligresti A, Mugnaini C, Brizzi A, Caradonna NP, Cascio MG, Bolognini D, Pertwee RG, Di Marzo V, Corelli F./titolo:Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors./doi:/rivista:European journal of medicinal chemistry (Online)/anno:2012/pagina_da:/pagina_a:/intervallo_pagine:/volume

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::b4ac8691278ed76bd114c964325868ad
https://publications.cnr.it/doc/194717

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Resorcinol-sn-Glycerol Derivatives: Novel 2-Arachidonoylglycerol Mimetics Endowed with High Affinity and Selectivity for Cannabinoid Type 1 Receptor

Autor: Brizzi A, Cascio MG, Frosini M, Ligresti A, Aiello F, Biotti I, Brizzi V, Pertwee RG, Corelli F, Di Marzo V.

Publikováno v: Journal of medicinal chemistry 54 (2011): 8278–8288.
info:cnr-pdr/source/autori:Brizzi A, Cascio MG, Frosini M, Ligresti A, Aiello F, Biotti I, Brizzi V, Pertwee RG, Corelli F, Di Marzo V./titolo:Resorcinol-sn-Glycerol Derivatives: Novel 2-Arachidonoylglycerol Mimetics Endowed with High Affinity and Selectivity for Cannabinoid Type 1 Receptor/doi:/rivista:Journal of medicinal chemistry/anno:2011/pagina_da:8278/pagina_a:8288/intervallo_pagine:8278–8288/volume:54

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::5482d12a44fec0e0c164c9537bb93145
https://publications.cnr.it/doc/16303

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