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Publikováno v:
Cancer Chemotherapy and Pharmacology. 5:139-144
The pharmacokinetic of 4'-deoxydoxorubicin, a new analog of doxorubicin, was compared with that of its parent compound in mice treated with equal and equiactive doses. The levels of total fluorescence due to the initial drugs and to metabolites were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffd327cdd28a4327ebb76cd189d61c4
https://doi.org/10.1007/bf00258470
https://doi.org/10.1007/bf00258470
Publikováno v:
Tumori Journal. 63:331-338
In rats repeatedly treated subcutaneously as infants with adriamycin in 2 cycles of 4 treatments each, the induction of ocular and dental abnormalities and tumors was studied. Cataracts appeared from 18 to 26 days in 80 % of CD rats treated with 1.15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e79f11b340c42007da625178b16214
https://doi.org/10.1177/030089167706300404
https://doi.org/10.1177/030089167706300404
Publikováno v:
Tumori Journal. 51:401-417
Swiss mice were intranasally infected with influenza A2 virus and treated with urethan in order to detect whether the joint action of the two agents would enhance the development of lung tumors. The average number per mouse of the typical lesions ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dfb1a91bb187ec406eb1b95db4328cf
https://doi.org/10.1177/030089166505100602
https://doi.org/10.1177/030089166505100602
Publikováno v:
Cancer Chemotherapy and Selective Drug Development ISBN: 9781461338390
The cytotoxic effect of Anthracyclines (Anthr) may be related to different parameters: a) affinity to DNA as expressed by the values of K app, b) cellular uptake, which can be related to partition coefficient lipids/water, c) interactions with cell m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::391f2347d18cca6648446ebbabfef4fb
https://doi.org/10.1007/978-1-4613-3837-6_51
https://doi.org/10.1007/978-1-4613-3837-6_51
Publikováno v:
Tumori. 66(5)
4-demethoxydaunorubicin was tested against experimental mouse leukemias, in comparison with doxorubicin and daunorubicin. 4-demethoxydaunorubicin, administered ip to mice bearing ascitic L1210 or F388 leukemia was 5 times more potent than daunorubici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43b8b2c0777b7a4f9cfe884c7c9c139
https://pubmed.ncbi.nlm.nih.gov/6936969
https://pubmed.ncbi.nlm.nih.gov/6936969
Autor:
Franco Zunino, S. Penco, Rosanna Supino, Alberto Bargiotti, Adriano Zaccara, Guiseppe Cassinelli, F. Arcamone, Casazza Am, Graziella Pratesi, A. Di Marco
Publikováno v:
Cancer chemotherapy and pharmacology. 10(2)
New 4′-C-methyl analogues of daunorubicin, synthesized by the coupling reaction of daunomycinone with 1-chloroderivatives of protected 4-C-methyldaunosamine analogues, were chemically transformed to the corresponding doxorubicin analogues. Their cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159da3666d60e30abe1dd3e038b62002
https://pubmed.ncbi.nlm.nih.gov/6831630
https://pubmed.ncbi.nlm.nih.gov/6831630
Publikováno v:
Anthracycline Antibiotics in Cancer Therapy ISBN: 9789400976320
In the last ten years several anthracycline glycosides related to doxorubicin have been obtained by semisynthesis, partial synthesis, total synthesis, biosynthesis and tested for “in vitro” and “in vivo” antitumor activity in our laboratories
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daa31e2129691e63cb94eb12792d15e4
https://doi.org/10.1007/978-94-009-7630-6_17
https://doi.org/10.1007/978-94-009-7630-6_17
Publikováno v:
Tumori. 64(2)
This paper describes the effect of Tween 80 on the antitumor activity and on the distribution of adriamycin in mice. The dilution of adriamycin in a 10% water solution of Tween 80 produced a significant increase of the antitumor activity in mice agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ca2450a63584c413a872415835a3db
https://pubmed.ncbi.nlm.nih.gov/675847
https://pubmed.ncbi.nlm.nih.gov/675847