Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid: community-based randomized clinical trial in Italy and the Netherlands

Autor: Bortolus, Renata, Blom, Fenneke, Filippini, Francesca, van Poppel, Mireille N. M., Leoncini, Emanuele, de Smit, Denhard J., Benetollo, Pier P., Cornel, Martina C., de Walle, Hermien E. K., Mastroiacovo, Pierpaolo, Compagni, Alessandra, Rigotti, Erika, di Lannoy, Antonella Noya, Coati, Marilisa, Manfrè, Silvia, Barbazza, Roberto, Zanconato, Giovanni, Zenorini, Maria Teresa, Travagliati, Vittorio, Mantovani, Elena, Angeli, Anna, Cavaliere, Elena, Cherubini, Greta, Negretto, Alice, Lavarini, Elena, Ozzi, Milena, Papadopoulos, Nikolaos, Di Mambro, Enrico, Vessella, Maddalena, Ettore, Giuseppe, Bianca, Sebastiano, Barone, Chiara, Cosmi, Erich, Visentin, Silvia, Camerin, Martina, Lanza, Paola, Marinangeli, Simonetta, Negrini, Giorgia, Ottaviani, Alberto, Zivelonghi, Laura, Baffoni, Andrea, Bertezzolo, Michaela, Pistolato, Mara, Ioverno, Enrico, Somigliana, Edgardo, Scarduelli, Claudia, Alagna, Federica, Santi, Giulia, Cesari, Elena, Zanini, Paola, Morandini, Achille, Cetin, Irene, Laoreti, Arianna, Tresso, Chiara, Grazia Salviato, Maria, Matterazzo, Marina, Failli, Carlo, Marzolini, Maurizia, Casaro, Anna, Balestreri, Debora, Benassi, Elena, Caloi, Elisa, Libero Giorgino, Francesco, Schiavo, Alessandra, Pietro Piazza, Gian, Ruffini, Renato, Jorizzo, Gianfranco, Cirelli, Gaetana, Arcidiacono, Francesca, De Toni, Anna, Rusconi, Silvia, Guaraldi, Claudia, Rosi, Patrizia, Mortaro, Graziella, Valotto, Laura, Guido, Angelo, Zanni, Giuliano, Vernier, Chiara, Sandri, Anna, Minisci, Nedelia

Publikováno v: BMC Pregnancy and Childbirth, 14:166. BMC
BMC Pregnancy and Childbirth
BMC Pregnancy and Childbirth, 14:166. BioMed Central
Bortolus, R, Blom, F, Filippini, F, van Poppel, M N M, Leoncini, E, de Smit, D J, Benetollo, P P, Cornel, M C, de Walle, H E K & Mastroiacovo, P 2014, ' Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid: community-based randomized clinical trial in Italy and the Netherlands ', BMC Pregnancy and Childbirth, vol. 14, 166 . https://doi.org/10.1186/1471-2393-14-166

In 2010 a Cochrane review confirmed that folic acid (FA) supplementation prevents the first- and second-time occurrence of neural tube defects (NTDs). At present some evidence from observational studies supports the hypothesis that FA supplementation

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https://research.rug.nl/en/publications/ecbe6ebf-e8c8-40c9-888e-3926902d69aa