Improvement of ALT decay kinetics by all-oral HCV treatment: role of NS5A inhibitors and differences with IFN-based regimens

Autor: Cento, Valeria, Nguyen, Thi Huyen Tram, Di Carlo, Domenico, Biliotti, Elisa, Gianserra, Laura, Lenci, Ilaria, Di Paolo, Daniele, Calvaruso, Vincenza, Teti, Elisabetta, Cerrone, Maddalena, Romagnoli, Dante, Melis, Michela, Danieli, Elena, Menzaghi, Barbara, Polilli, Ennio, Siciliano, Massimo, Nicolini, Laura Ambra, Di Biagio, Antonio, Magni, Carlo Federico, Bolis, Matteo, Antonucci, Francesco Paolo, Di Maio, Velia Chiara, Alfieri, Roberta, Sarmati, Loredana, Casalino, Paolo, Bernardini, Sergio, Micheli, Valeria, Rizzardini, Giuliano, Parruti, Giustino, Quirino, Tiziana, Puoti, Massimo, Babudieri, Sergio, D'Arminio Monforte, Antonella, Andreoni, Massimo, Craxì, Antonio, Angelico, Mario, Pasquazzi, Caterina, Ceccherini-Silberstein, Francesca

Background: Intracellular HCV-RNA reduction is a proposed mechanism of action of direct-acting antivirals (DAAs), alternative to hepatocytes elimination by pegylated-interferon plus ribavirin (PR). We modeled ALT and HCV-RNA kinetics in cirrhotic pat

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http://eprints.uniss.it/11801/

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Improvement of ALT decay kinetics by all-oral HCV treatment: Role of NS5A inhibitors and differences with IFN-based regimens.

Autor: Cento V; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy., Nguyen THT; INSERM, Université Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France., Di Carlo D; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy., Biliotti E; Tropical Diseases, Umberto I Hospital - 'Sapienza' University, Rome, Italy., Gianserra L; Infectious Diseases, Sant'Andrea Hospital - 'Sapienza' University, Rome, Italy., Lenci I; Hepatology Unit, Polyclinic of Rome Tor Vergata, Rome, Italy., Di Paolo D; Hepatology Unit, Polyclinic of Rome Tor Vergata, Rome, Italy., Calvaruso V; Gastroenterology, 'P. Giaccone' University Hospital, Palermo, Italy., Teti E; Infectious Diseases, Polyclinic of Rome Tor Vergata, Rome, Italy., Cerrone M; Clinic of Infectious Disease, Department of Health Sciences, San Paolo University Hospital, University of Milan, Milan, Italy., Romagnoli D; Department of Biomedical, Metabolic and Neural Sciences, NOCSAE Baggiovara, Baggiovara, Modena, Italy., Melis M; Infectious Diseases Unit, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy., Danieli E; Infectious Diseases, AO Ospedale Niguarda Cà Granda, Milan, Italy., Menzaghi B; Infectious Diseases, Ospedale di circolo di Busto Arsizio, Busto Arsizio, Varese, Italy., Polilli E; Infectious Disease Unit, 'Spirito Santo' General Hospital, Pescara, Italy., Siciliano M; Gastroenterology, Catholic University of Rome, Rome, Italy., Nicolini LA; University of Genoa (DISSAL) Infectious Diseases Unit/AOU IRCCS San Martino-IST, Genoa, Italy., Di Biagio A; University of Genoa (DISSAL) Infectious Diseases Unit/AOU IRCCS San Martino-IST, Genoa, Italy., Magni CF; 1st Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Milan, Italy., Bolis M; 1st Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Milan, Italy., Antonucci FP; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy., Di Maio VC; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy., Alfieri R; Istituto Nazionale di Genetica Molecolare (INGM) 'Romeo ed Enrica Invernizzi', Milan, Italy., Sarmati L; Infectious Diseases, Polyclinic of Rome Tor Vergata, Rome, Italy., Casalino P; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy., Bernardini S; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy., Micheli V; Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, Milan, Italy., Rizzardini G; 1st Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Milan, Italy.; School of Clinical Medicine, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa., Parruti G; Infectious Disease Unit, 'Spirito Santo' General Hospital, Pescara, Italy., Quirino T; Infectious Diseases, Ospedale di circolo di Busto Arsizio, Busto Arsizio, Varese, Italy., Puoti M; Infectious Diseases, AO Ospedale Niguarda Cà Granda, Milan, Italy., Babudieri S; Infectious Diseases Unit, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy., D'Arminio Monforte A; Clinic of Infectious Disease, Department of Health Sciences, San Paolo University Hospital, University of Milan, Milan, Italy., Andreoni M; Infectious Diseases, Polyclinic of Rome Tor Vergata, Rome, Italy., Craxì A; Gastroenterology, 'P. Giaccone' University Hospital, Palermo, Italy., Angelico M; Hepatology Unit, Polyclinic of Rome Tor Vergata, Rome, Italy., Pasquazzi C; Infectious Diseases, Sant'Andrea Hospital - 'Sapienza' University, Rome, Italy., Taliani G; Tropical Diseases, Umberto I Hospital - 'Sapienza' University, Rome, Italy., Guedj J; INSERM, Université Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France., Perno CF; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy., Ceccherini-Silberstein F; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.

Publikováno v: PloS one [PLoS One] 2017 May 18; Vol. 12 (5), pp. e0177352. Date of Electronic Publication: 2017 May 18 (Print Publication: 2017).