Výsledky vyhledávání - "Casaccia-Bonnefil P"

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

Autor: Shen S, Sandoval J, Swiss VA, Li J, Dupree J, Franklin RJ, Casaccia-Bonnefil P

Publikováno v: NATURE NEUROSCIENCE
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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The efficiency of remyelination decreases with age, but the molecular mechanisms responsible for this decline remain only partially understood. In this study, we show that remyelination is regulated by age-dependent epigenetic control of gene express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::118d6a5d06c28a14b403068842d2d9fc
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=5068

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Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination

Autor: Li J, Ghiani CA, Kim JY, Liu A, Sandoval J, DeVellis J, Casaccia-Bonnefil P

Publikováno v: JOURNAL OF NEUROSCIENCE
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Oligodendrogliopathy, microglial infiltration, and lack of remyelination are detected in the brains of patients with multiple sclerosis and are accompanied by high levels of the transcription factor p53. In this study, we used the cuprizone model of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::8c8e1ebc951fdd09eaf42db58d396385
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=5070

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Events at the transition between cell cycle exit and oligodendrocyte progenitor differentiation: the role of HDAC and YY1

Autor: He Y, Sandoval J, Casaccia-Bonnefil P

Publikováno v: NEURON GLIA BIOL
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

The complexity of the adult brain is the result of an integrated series of developmental events that depends on appropriate timing of differentiation. The importance of transcriptional regulatory networks and epigenetic mechanisms of regulation of ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::e3786b78ced03f9c68135f05fe5ca4ac
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=5069

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The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation

Autor: He Y, Dupree J, Wang J, Sandoval J, Li J, Liu H, Shi Y, Nave KA, Casaccia-Bonnefil P

Publikováno v: Neuron
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

The progression of progenitors to oligodendrocytes requires proliferative arrest and the activation of a transcriptional program of differentiation. While regulation of cell cycle exit has been extensively characterized, the molecular mechanisms resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::34650b292a378b896a725679b594a6f3
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=5072

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