Zobrazeno 1 - 10
of 17 656
pro vyhledávání: '"Cas9"'
Autor:
Hillary Elrick, Kevin A. Peterson, Brandon J. Willis, Denise G. Lanza, Elif F. Acar, Edward J. Ryder, Lydia Teboul, Petr Kasparek, Marie-Christine Birling, David J. Adams, Allan Bradley, Robert E. Braun, Steve D. Brown, Adam Caulder, Gemma F. Codner, Francesco J. DeMayo, Mary E. Dickinson, Brendan Doe, Graham Duddy, Marina Gertsenstein, Leslie O. Goodwin, Yann Hérault, Lauri G. Lintott, K. C. Kent Lloyd, Isabel Lorenzo, Matthew Mackenzie, Ann-Marie Mallon, Colin McKerlie, Helen Parkinson, Ramiro Ramirez-Solis, John R. Seavitt, Radislav Sedlacek, William C. Skarnes, Damien Smedley, Sara Wells, Jacqueline K. White, Joshua A. Wood, International Mouse Phenotyping Consortium, Stephen A. Murray, Jason D. Heaney, Lauryl M. J. Nutter
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The International Mouse Phenotyping Consortium (IMPC) systematically produces and phenotypes mouse lines with presumptive null mutations to provide insight into gene function. The IMPC now uses the programmable RNA-guided nuclease Cas9 for i
Externí odkaz:
https://doaj.org/article/0788cc9d0e59472c90243baecc221f96
Publikováno v:
Journal of Advanced Research, Vol 63, Iss , Pp 73-90 (2024)
Introduction: Our previous work reveals a critical role of activation of neuronal Alox5 in exacerbating brain injury post seizures. However, whether neuronal Alox5 impacts the pathological process of epilepsy remains unknown. Objectives: To prove the
Externí odkaz:
https://doaj.org/article/2c7cc60d53ed4ac5b64bd5ce967d8684
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Since the introduction of next generation sequencing technologies, the field of epigenomics has evolved rapidly. However, most commonly used assays are enrichment-based methods and thus only semi-quantitative. Nucleosome occupancy and methyl
Externí odkaz:
https://doaj.org/article/d24fbde6bfc84185b1006c146eb010a9
Publikováno v:
BMC Research Notes, Vol 17, Iss 1, Pp 1-6 (2024)
Abstract Objective Insertion and deletion (indel) analysis of CRISPR-Cas guide RNAs (gRNAs) is crucial in gene editing to assess gRNA efficiency and indel frequency. This study evaluates the utility of CRISPResso2 with Oxford Nanopore sequencing data
Externí odkaz:
https://doaj.org/article/be93d1b323764efb99057021330392f8
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The contraction of CAG/CTG repeats is an attractive approach to correct the mutation that causes at least 15 neuromuscular and neurodegenerative diseases, including Huntington’s disease and Myotonic Dystrophy type 1. Contractions can be ac
Externí odkaz:
https://doaj.org/article/18056ebe522b4678a7b61f4ef8107959
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-9 (2024)
Abstract Due to limitations in conventional disease vector control strategies including the rise of insecticide resistance in natural populations of mosquitoes, genetic control strategies using CRISPR gene drive systems have been under serious consid
Externí odkaz:
https://doaj.org/article/83d9ac40bb234251b5065e133f5694e3
Autor:
Heng Zhou, Peng Ye, Wei Xiong, Xingxiang Duan, Shuili Jing, Yan He, Zhi Zeng, Yen Wei, Qingsong Ye
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-30 (2024)
Abstract Due to the rapid development of stem cell technology, there have been tremendous advances in molecular biological and pathological research, cell therapy as well as organoid technologies over the past decades. Advances in genome editing tech
Externí odkaz:
https://doaj.org/article/0792706ffc93464fb6cd5efccb9b4bf9
Autor:
Bashdar Mahmud Hussen, Zana Baqi Najmadden, Snur Rasool Abdullah, Mohammed Fatih Rasul, Suhad A. Mustafa, Soudeh Ghafouri-Fard, Mohammad Taheri
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Respiratory disorders are among the conditions that affect the respiratory system. The healthcare sector faces challenges due to the emergence of drug resistance to prescribed medications for these illnesses. However, there is a technology c
Externí odkaz:
https://doaj.org/article/b22fe0c5d78d4d25b3e1d04e3800d09d
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 937-944 (2024)
Bacteriophages have been used across various fields, and the utilization of CRISPR/Cas-based genome editing technology can accelerate the research and applications of bacteriophages. However, some bacteriophages can escape from the cleavage of Cas pr
Externí odkaz:
https://doaj.org/article/5510b4316a6a4979a56f8e169ff12ef6
Autor:
Athar Khalil
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/cb38e25b2a934e3ca4161267671e1308