Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Carys Pugh"'
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0296014 (2024)
BackgroundFrailty is characterised by a reduced resilience to adversity. In this analysis we examined changes in frailty in people aged 50+ before and during a period of austere public spending in England.MethodsData from the English Longitudinal Stu
Externí odkaz:
https://doaj.org/article/0dd22f388a65415987604756ec0bd694
Autor:
Andrew McIntosh, Matthew Henry Iveson, Colin N A Palmer, Emily L Ball, Jason Doherty, Carys Pugh, Shobna Vashishta
Publikováno v:
BMJ Open, Vol 14, Iss 1 (2024)
Purpose The SHARE Mental Health (SHARE-MH) cohort was established to address the paucity of clinical and genetic data available for mental health research. The cohort brings together detailed mental health questionnaire responses, routinely collected
Externí odkaz:
https://doaj.org/article/34779262438b46e29353720adb6bb825
Autor:
Mihail Halachev, Alison Meynert, Martin S Taylor, Veronique Vitart, Shona M Kerr, Lucija Klaric, S. G. P. Consortium, Timothy J Aitman, Chris S Haley, James G Prendergast, Carys Pugh, David A Hume, Sarah E Harris, David C Liewald, Ian J Deary, Colin A Semple, James F Wilson
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008480 (2019)
Human population isolates provide a snapshot of the impact of historical demographic processes on population genetics. Such data facilitate studies of the functional impact of rare sequence variants on biomedical phenotypes, as strong genetic drift c
Externí odkaz:
https://doaj.org/article/09ea862e75084e98bfa75eb5fa8e4a38
Autor:
Allan Beveridge, James Prendergast, David Wragg, David A. Hume, Carys Pugh, Qian Liu, Valentina Riggio, Albert Tenesa, Helen Brown, Zeng Lin, Ian J. Deary, Sarah E. Harris
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Wragg, D, Liu, Q, Lin, Z, Riggio, V, Pugh, C, Beveridge, A, Brown, H, Hume, D, Harris, S, Deary, I, Tenesa, A & Prendergast, J 2020, ' Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalization ', Nature Communications, vol. 11, no. 1, 343 . https://doi.org/10.1038/s41467-019-13762-6
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Wragg, D, Liu, Q, Lin, Z, Riggio, V, Pugh, C, Beveridge, A, Brown, H, Hume, D, Harris, S, Deary, I, Tenesa, A & Prendergast, J 2020, ' Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalization ', Nature Communications, vol. 11, no. 1, 343 . https://doi.org/10.1038/s41467-019-13762-6
The extent to which the impact of regulatory genetic variants may depend on other factors, such as the expression levels of upstream transcription factors, remains poorly understood. Here we report a framework in which regulatory variants are first a
Autor:
Stuart H. Ralston, Nerea Alonso, Ian J. Deary, Kathryn Berg, Beatriz Larraz-Prieto, James Prendergast, Sarah E. Harris, Zoe Lambert, Carys Pugh, Paul Redmond
Publikováno v:
Alonso, N, Larraz-Prieto, B, Berg, K, Lambert, Z, Redmond, P, Harris, S E, Deary, I J, Pugh, C, Prendergast, J & Ralston, S H 2020, ' Loss-of-function mutations in the ALPL gene presenting with adult onset osteoporosis and low serum concentrations of total alkaline phosphatase ', Journal of Bone and Mineral Research, vol. 35, no. 4, pp. 657-661 . https://doi.org/10.1002/jbmr.3928
Hypophosphatasia (HPP) is a rare inherited disorder characterized by rickets and low circulating concentrations of total alkaline phosphatase (ALP) caused by mutations in ALPL. Severe HPP presents in childhood but milder forms can present in adulthoo
Autor:
Allan Beveridge, Ian J. Deary, David A. Hume, Sarah E. Harris, Carys Pugh, James G. D. Prendergast
Publikováno v:
Genome Biology and Evolution
Despite the fundamental importance of single nucleotide polymorphisms (SNPs) to human evolution there are still large gaps in our understanding of the forces that shape their distribution across the genome. SNPs have been shown to not be distributed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d3f49552ba9d0798e37d6583a7d462
Publikováno v:
Canine Genetics and Epidemiology
Pugh, C, Bronsvoort, M, Handel, I G, Summers, K M & Clements, D N 2014, ' What can cohort studies in the dog tell us? ' vol. 1, no. 1, pp. 5 . DOI: 10.1186/2052-6687-1-5
Pugh, C, Bronsvoort, M, Handel, I G, Summers, K M & Clements, D N 2014, ' What can cohort studies in the dog tell us? ' vol. 1, no. 1, pp. 5 . DOI: 10.1186/2052-6687-1-5
This paper addresses the use of cohort studies in canine medicine to date and highlights the benefits of wider use of such studies in the future. Uniquely amongst observational studies, cohort studies offer the investigator an opportunity to assess t
Autor:
Ian Handel, Damon Querry, B. Mark C de Bronsvoort, Carys Pugh, Dylan N. Clements, Erica Rose, William E R Ollier, Kenton L. Morgan, Kim M. Summers, Jeffery Sampson, Lorna J. Kennedy
Publikováno v:
BMC Veterinary Research
BMC Veterinary Research, Vol 9, Iss 1, p 13 (2013)
Clements, D N, Handel, I G, Rose, E, Querry, D, Pugh, C, Ollier, W E R, Morgan, K L, Kennedy, L J, Sampson, J, Summers, K M & Bronsvoort, M 2013, ' Dogslife: A web-based longitudinal study of Labrador Retriever health in the UK ', BMC Veterinary Research, vol. 9, no. January 2013, 13, pp. 1-15 . https://doi.org/10.1186/1746-6148-9-13
BMC Veterinary Research, Vol 9, Iss 1, p 13 (2013)
Clements, D N, Handel, I G, Rose, E, Querry, D, Pugh, C, Ollier, W E R, Morgan, K L, Kennedy, L J, Sampson, J, Summers, K M & Bronsvoort, M 2013, ' Dogslife: A web-based longitudinal study of Labrador Retriever health in the UK ', BMC Veterinary Research, vol. 9, no. January 2013, 13, pp. 1-15 . https://doi.org/10.1186/1746-6148-9-13
Background Dogslife is the first large-scale internet-based longitudinal study of canine health. The study has been designed to examine how environmental and genetic factors influence the health and development of a birth cohort of UK-based pedigree