Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor

Autor: Hisham Mohammed, Clive D’Santos, Aurelien A. Serandour, H. Raza Ali, Gordon D. Brown, Alan Atkins, Oscar M. Rueda, Kelly A. Holmes, Vasiliki Theodorou, Jessica L.L. Robinson, Wilbert Zwart, Amel Saadi, Caryn S. Ross-Innes, Suet-Feung Chin, Suraj Menon, John Stingl, Carlo Palmieri, Carlos Caldas, Jason S. Carroll

Publikováno v: Cell Reports, Vol 3, Iss 2, Pp 342-349 (2013)

Estrogen receptor-α (ER) is the driving transcription factor in most breast cancers, and its associated proteins can influence drug response, but direct methods for identifying interacting proteins have been limited. We purified endogenous ER using

Externí odkaz: https://doaj.org/article/82f5e9bc92054011ab7cc4d25829df4b

FOXA1 is a key determinant of estrogen receptor function and endocrine response

Autor: Dominic Schmidt, Caryn S. Ross-Innes, Jason S. Carroll, Kelly A. Holmes, Antoni Hurtado

Publikováno v: Nature Genetics
Nature genetics

Estrogen Receptor-α (ER) is the key feature in the majority of breast cancers and ER binding to the genome correlates with the Forkhead protein FOXA1 (HNF3α). We now show that FOXA1 is a critical determinant that can influence differential ER-chrom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d5fe900cc98fe14792119a9086c5ec
https://doi.org/10.1038/ng.730

Evaluation of a minimally invasive cell sampling device coupled with assessment of trefoil factor 3 expression for diagnosing Barrett's esophagus: a multi-center case-control study

Autor: Caryn S, Ross-Innes, Irene, Debiram-Beecham, Maria, O'Donovan, Elaine, Walker, Sibu, Varghese, Pierre, Lao-Sirieix, Laurence, Lovat, Michael, Griffin, Krish, Ragunath, Rehan, Haidry, Sarmed S, Sami, Philip, Kaye, Marco, Novelli, Babett, Disep, Richard, Ostler, Benoit, Aigret, Bernard V, North, Pradeep, Bhandari, Adam, Haycock, Danielle, Morris, Stephen, Attwood, Anjan, Dhar, Colin, Rees, Matthew D D, Rutter, Peter D, Sasieni, Rebecca C, Fitzgerald, Sharon, Cave

Publikováno v: Ross-Innes, C S, Debiram-Beecham, I, O'Donovan, M, Walker, E, Varghese, S, Lao-Sirieix, P, Lovat, L, Griffin, M, Ragunath, K, Haidry, R, Sami, S S, Kaye, P, Novelli, M, Disep, B, Ostler, R, Aigret, B, North, B V, Bhandari, P, Haycock, A, Morris, D, Attwood, S, Dhar, A, Rees, C, Rutter, M D D, Sasieni, P D & Fitzgerald, R C 2015, ' Evaluation of a Minimally Invasive Cell Sampling Device Coupled with Assessment of Trefoil Factor 3 Expression for Diagnosing Barrett's Esophagus : A Multi-Center Case–Control Study ', PLoS Medicine, vol. 12, no. 1, e1001780 . https://doi.org/10.1371/journal.pmed.1001780
PLoS Medicine
PLoS Medicine, Vol 12, Iss 1, p e1001780 (2015)

Background Barrett's esophagus (BE) is a commonly undiagnosed condition that predisposes to esophageal adenocarcinoma. Routine endoscopic screening for BE is not recommended because of the burden this would impose on the health care system. The objec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ffac5eb22389dbfab29d33677ecb97
https://pubmed.ncbi.nlm.nih.gov/25645931

The '-omics' revolution and oesophageal adenocarcinoma

Autor: Caryn S. Ross-Innes, Rebecca C. Fitzgerald, Jamie M J Weaver

Publikováno v: Nature reviews. Gastroenterologyhepatology. 11(1)

Oesophageal adenocarcinoma (OAC) is the eighth most common cancer type worldwide with a dismal 5-year survival. Barrett oesophagus, the replacement of the normal squamous epithelia with glandular cells, is the first step in the pathway towards OAC. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9059bff5973013c24aa720b7aeae9138
https://pubmed.ncbi.nlm.nih.gov/23982683

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

Autor: Caryn S. Ross-Innes, Rory Stark, Andrew E. Teschendorff, Kelly A. Holmes, H. Raza Ali, Mark J. Dunning, Gordon D. Brown, Ondrej Gojis, Ian O. Ellis, Andrew R. Green, Simak Ali, Suet-Feung Chin, Carlo Palmieri, Carlos Caldas, Jason S. Carroll

Publikováno v: Nature

Oestrogen receptor-α (ER) is the defining and driving transcription factor in the majority of breast cancers and its target genes dictate cell growth and endocrine response, yet genomic understanding of ER function has been restricted to model syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157df856834992cd47063705aab9da3a
https://www.repository.cam.ac.uk/handle/1810/268192