Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Caryn Hepburn"'
Autor:
Zhong Guo, Oleh Smutok, Wayne A. Johnston, Patricia Walden, Jacobus P. J. Ungerer, Thomas S. Peat, Janet Newman, Jake Parker, Tom Nebl, Caryn Hepburn, Artem Melman, Richard J. Suderman, Evgeny Katz, Kirill Alexandrov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Efforts to engineer artificial allosteric systems are ongoing. Here the authors analyse factors influencing development of artificial small molecule:protein complexes that act as chemically induced dimerization (CID) systems; they use one of the CIDs
Externí odkaz:
https://doaj.org/article/3137900910a3487b8be8037ec6136e0f
Autor:
Sarah L. Mueller, Panagiotis K. Chrysanthopoulos, Maria A. Halili, Caryn Hepburn, Tom Nebl, Claudiu T. Supuran, Alessio Nocentini, Thomas S. Peat, Sally-Ann Poulsen
Publikováno v:
Molecules, Vol 26, Iss 10, p 3010 (2021)
The approved drugs that target carbonic anhydrases (CA, EC 4.2.1.1), a family of zinc metalloenzymes, comprise almost exclusively of primary sulfonamides (R-SO2NH2) as the zinc binding chemotype. New clinical applications for CA inhibitors, particula
Externí odkaz:
https://doaj.org/article/0ec974b2c60a4f64bb86c3ef69b3a8b3
Autor:
Cassidy Whitefield, Yen Vo, Brett D Schwartz, Caryn Hepburn, F. Hafna Ahmed, Hideki Onagi, Martin G. Banwell, Keats Nelms, Lara R. Malins, Colin J Jackson
Heparanase (HPSE) is the only mammalian endo-β-glucuronidase known to catalyse the degradation of heparan sulfate. Dysfunction of HPSE activity has been linked to several disease states, resulting in HPSE becoming the target of numerous therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de600e29d867970f528c2f6ba57ec3cb
https://doi.org/10.1101/2023.01.05.522817
https://doi.org/10.1101/2023.01.05.522817
Autor:
Maria A. Halili, Thomas S. Peat, Sarah L Mueller, Sally-Ann Poulsen, Alessio Nocentini, Tom Nebl, Panagiotis K. Chrysanthopoulos, Caryn Hepburn, Claudiu T. Supuran
Publikováno v:
Molecules
Molecules, Vol 26, Iss 3010, p 3010 (2021)
Volume 26
Issue 10
Molecules, Vol 26, Iss 3010, p 3010 (2021)
Volume 26
Issue 10
The approved drugs that target carbonic anhydrases (CA, EC 4.2.1.1), a family of zinc metalloenzymes, comprise almost exclusively of primary sulfonamides (R-SO2NH2) as the zinc binding chemotype. New clinical applications for CA inhibitors, particula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57f30ab1a7e98eacd91452152d69250
https://pubmed.ncbi.nlm.nih.gov/34070212
https://pubmed.ncbi.nlm.nih.gov/34070212