Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Cary Weinberger"'
Publikováno v:
Insect Biochemistry and Molecular Biology. 33:1239-1247
Insect development is guided by the combined actions of ecdysteroids and juvenile hormones (JHs). The transcriptional effects of ecdysteroids are mediated by a protein complex consisting of the ecdysone receptor (EcR) and its heterodimeric partner, U
Publikováno v:
Journal of Biological Chemistry. 275:10918-10924
Cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription is repressed by bile acids. The goal of this study is to elucidate the mechanism of CYP7A1 transcription by bile acid-activated farnesoid X receptor (FXR) in its native promoter and cellular
Autor:
R A Heyman, Leo T. Burka, D E Mais, Kenneth B. Tomer, S Kitareewan, Robert Stevens, Leesa J. Deterding, B M Forman, Carol E. Parker, T McMorris, Cary Weinberger
Publikováno v:
Molecular Biology of the Cell. 7:1153-1166
RXR is a nuclear receptor that plays a central role in cell signaling by pairing with a host of other receptors. Previously, 9-cis-retinoic acid (9cRA) was defined as a potent RXR activator. Here we describe a unique RXR effector identified from orga
Autor:
Daniel J. Noonan, Ronald M. Evans, Thomas Perlmann, Jasmine Chen, Elizabeth Goode, Anthony E. Oro, Cary Weinberger, William W Lamph, Leo T. Burka, Barry M. Forman, David J. Bradley, Trevor C. McMorris
Publikováno v:
Cell. 81(5):687-693
Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A growing number of related proteins have been identified that posses
Autor:
G Cerelli, Michael G. Rosenfeld, E B Thompson, Anthony E. Oro, Roger V. Lebo, Stanley M. Hollenberg, Estelita S. Ong, Cary Weinberger, Ronald M. Evans
Publikováno v:
Nature. 318:635-641
Identification of complementary DNAs encoding the human glucocorticoid receptor predicts two protein forms, of 777 (alpha) and 742 (beta) amino acids, which differ at their carboxy termini. The proteins contain a cysteine/lysine/arginine-rich region
Publikováno v:
Cell. 31:543-551
Two adenovirus type 5 mutants were constructed to probe the function of the virus-encoded RNA polymerase III transcripts (VA RNAs). Each mutant fails to synthesize one of the two VA RNA species. The variant that does not produce the minor VAII specie
Publikováno v:
Scopus-Elsevier
Autor:
Thomas M Glaser, Ronald M. Evans, Jeffrey L. Arriza, Barbara Handelin, Cary Weinberger, Gail M. Cerelli, David E. Housman
Publikováno v:
Science. 237:268-275
Low-stringency hybridization with human glucocorticoid receptor (hGR) complementary DNA was used to isolate a new gene encoding a predicted 107-kilodalton polypeptide. Expression studies demonstrate its ability to bind aldosterone with high affinity
Autor:
Ronald M. Evans, Rodrigo Franco, Cary Weinberger, Michael G. Rosenfeld, Vivian R. Albert, Christopher K. Glass
Publikováno v:
Nature. 329:738-741
The substance 3,5,3-triiodothyronine (T3) stimulates growth hormone gene transcription in rat pituitary tumour cells1–4. This stimulation is thought to be mediated by the binding of nuclear T3 receptors to regulatory elements 5' to the transcriptio
Autor:
E B Thompson, JM Harmon, Michael G. Rosenfeld, S. M. Hollenberg, John A. Cidlowski, Cary Weinberger, Ronald M. Evans, Brower St, Estelita S. Ong
Publikováno v:
Science. 228:740-742
Steroid hormones regulate cellular differentiation and physiologic functions predominantly through gene transcription. Regulation is achieved by the interaction of specific steroid receptor proteins and target genes. Expression cloning techniques wer