Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Cary Queen"'
Publikováno v:
Molecular Cancer Therapeutics. 11:864-872
Expression of fibroblast growth factor 2 (FGF2) is believed to be a contributing factor to the growth of a number of tumor types, including hepatocellular carcinoma (HCC). However, the potential of monoclonal antibodies that neutralize FGF2 for treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c49e800765ead5bef905dd6a011eb8d
https://doi.org/10.1158/1535-7163.mct-11-0813
https://doi.org/10.1158/1535-7163.mct-11-0813
A very large diversity space of synthetically accessible compounds for use with drug design programs
Autor:
Olga Demina, Evgeny Mazin, Peter K. Vlasov, Anatoliy Rubinov, Maxim Smolov, Dmitry Lepikhin, Cary Queen, Viktor Zosimov, Natalia Zaitseva, Valery V. Fokin, Denis Khachko, S. I. Nikitin, Sergey Mikhalev, Vera Solovieva
Publikováno v:
Journal of Computer-Aided Molecular Design. 19:47-63
We have constructed a very large virtual diversity space containing more than 10(13) chemical compounds. The diversity space is built from about 400 combinatorial libraries, which have been expanded by choosing sizeable collections of suitable R-grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f116b87ba279be0f3a463996ecda759a
https://doi.org/10.1007/s10822-005-0097-6
https://doi.org/10.1007/s10822-005-0097-6
Autor:
Cary Queen, Kevin J. Whaley, Richard A. Cone, Stuart S. Olmsted, Man Sung Co, David R. Russell, Larry Zeitlin, Brian J. Martinell, Vikram M. Paradkar, Thomas R. Moench
Publikováno v:
Nature Biotechnology. 16:1361-1364
The ability to produce monoclonal antibodies (Mabs) in plants offers the opportunity for the development of an inexpensive method of mucosal immunoprotection against sexually transmitted diseases. To investigate the suitability of plant-expressed Mab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266894425dca24c7db79d4fe7500f793
https://doi.org/10.1038/4344
https://doi.org/10.1038/4344
Autor:
Man Sung Co, Cary Queen
Publikováno v:
Nature. 351:501-502
Protein engineering has made it possible to combine the binding sites of murine antibodies with human antibody regions. Antibodies constructed in this way have important advantages for therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0475ee6c17d4adc80ac418229f99af10
https://doi.org/10.1038/351501a0
https://doi.org/10.1038/351501a0
Autor:
Le Thi Bich-Thuy, Cary Queen
Publikováno v:
Nucleic Acids Research. 17:5307-5322
We have developed a system to study transcriptional regulation of the lambda immunoglobulin gene in a natural setting -- lambda light chain producing lymphoid cells. This assay system has allowed the detection of an enhancer element located 3' of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93cddc2fb52c19039f2d265f9b5953d6
https://doi.org/10.1093/nar/17.13.5307
https://doi.org/10.1093/nar/17.13.5307
Publikováno v:
European Journal of Immunology. 16:547-550
Human B cells were cultured without added lymphokines, with interleukin 2 (IL2) or interferon-gamma (IFN-gamma) alone, or with a combination of IL2 and IFN-gamma. Treatment with IL2 alone induced differentiation of the B cells, as shown by an increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00e017af989f53bb57b27d3498d0e84
https://doi.org/10.1002/eji.1830160515
https://doi.org/10.1002/eji.1830160515
Autor:
Cary Queen, Martin Rosenberg
Publikováno v:
Cell. 25:241-249
We have used an mRNA-dependent E. coli S-30 translation system to compare the translation efficiencies of two polycistronic transcripts of the galactose operon, the CRP-cAMP-dependent mRNA (P1) and the CRP-cAMP-independent mRNA (P2). The RNAs were pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109a412222dbefca5ceab0c389cc7f31
https://doi.org/10.1016/0092-8674(81)90249-x
https://doi.org/10.1016/0092-8674(81)90249-x
Publikováno v:
Nucleic Acids Research. 9:5553-5568
The dominant family of interspersed repetitive DNA sequences in the human genome has been termed the Alu family. We have found that more than 75% of the lambda phage in a recombinant library representing an African green monkey genome hybridize with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c0f322fb3c5e02d10cdc438f677922
https://doi.org/10.1093/nar/9.21.5553
https://doi.org/10.1093/nar/9.21.5553
Publikováno v:
Immunological Reviews. 89:49-68
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1deb00ad9ce97424b6dae0e52433625
https://doi.org/10.1111/j.1600-065x.1986.tb01472.x
https://doi.org/10.1111/j.1600-065x.1986.tb01472.x
Autor:
Cary Queen, Laurence Jay Korn
Publikováno v:
DNA. 3:421-436
We review a wide range of programs for micro- and minicomputers that facilitate the collection and analysis of DNA, RNA, or protein sequences. Special-purpose programs that perform a single function and general-purpose programs that perform a set of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ffe46292d0e8d523e1e5722ed930d0
https://doi.org/10.1089/dna.1.1984.3.421
https://doi.org/10.1089/dna.1.1984.3.421