Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Cary D Austin"'
Autor:
Arna Katewa, Eric Suto, Jessica Hui, Jose Heredia, Jie Liang, Jason Hackney, Keith Anderson, Tuija M Alcantar, Natasha Bacarro, Debra Dunlap, Jeffrey Eastham, Andres Paler-Martinez, Xin Y Rairdan, Zora Modrusan, Wyne P Lee, Cary D Austin, Daniel Lafkas, Nico Ghilardi
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0244439 (2021)
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease representing a serious unmet medical need. The disease is associated with the loss of self-tolerance and exaggerated B cell activation, resulting in autoantibody production and the fo
Externí odkaz:
https://doaj.org/article/ed0d04cf471f47d69accfbf3ee12f167
Autor:
Cary M. Looney, MS, Aaron Schroeder, BS, Erica Tavares, BSN, Jay Garg, MD, MBA, Thomas Schindler, PhD, Flavio Vincenti, MD, Robert R. Redfield, MD, Stanley C. Jordan, MD, Stephan Busque, MD, E. Steve Woodle, MD, Jared Khan, MS, Jeffrey Eastham, MS, Sandrine Micallef, PhD, Cary D. Austin, MD, PhD, Alyssa Morimoto, PhD
Publikováno v:
Transplantation Direct, Vol 9, Iss 2, p e1436 (2023)
Background. The THEORY study evaluated the effects of single and multiple doses of obinutuzumab, a type 2 anti-CD20 antibody that induces antibody-dependent cell-mediated cytotoxicity and direct cell death, in combination with standard of care in pat
Externí odkaz:
https://doaj.org/article/10259b2ed34f4a58b4712c88b2dfd5e4
Autor:
Latifa Khalfaoui, Fiona A. Symon, Simon Couillard, Beverley Hargadon, Rekha Chaudhuri, Steve Bicknell, Adel H. Mansur, Rahul Shrimanker, Timothy S. C. Hinks, Ian D. Pavord, Stephen J. Fowler, Vanessa Brown, Lorcan P. McGarvey, Liam G. Heaney, Cary D. Austin, Peter H. Howarth, Joseph R. Arron, David F. Choy, Peter Bradding
Publikováno v:
Khalfaoui, L, Symon, F A, Couillard, S, Hargadon, B, Chaudhuri, R, Bicknell, S, Mansur, A H, Shrimanker, R, Hinks, TS C, Pavord, I D, Fowler, S J, Brown, V, McGarvey, L P, Heaney, L G, Austin, C D, Howarth, P H, Arron, J R, Choy, D F & Bradding, P 2022, ' Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker-high and -low severe asthma ', Allergy . https://doi.org/10.1111/all.15376
UK Medical Research Council Refractory Asthma Stratification programme (RASP-UK) 2022, ' Airway remodelling rather than cellular infiltration characterises both type2 cytokine biomarker-high and-low severe asthma ', Allergy . https://doi.org/10.1111/all.15376
UK Medical Research Council Refractory Asthma Stratification programme (RASP-UK) 2022, ' Airway remodelling rather than cellular infiltration characterises both type2 cytokine biomarker-high and-low severe asthma ', Allergy . https://doi.org/10.1111/all.15376
Background: The most recognizable phenotype of severe asthma comprises people who are blood eosinophil and FeNO-high, driven by type-2 (T2) cytokine biology which responds to targeted biological therapies. However, in many people with severe asthma,
Autor:
WeiYu Lin, Daqi Xu, Cary D. Austin, Patrick Caplazi, Kate Senger, Yonglian Sun, Surinder Jeet, Judy Young, Donnie Delarosa, Eric Suto, Zhiyu Huang, Juan Zhang, Donghong Yan, Cesar Corzo, Kai Barck, Sharmila Rajan, Carrie Looney, Vineela Gandham, Justin Lesch, Wei-Ching Liang, Elaine Mai, Hai Ngu, Navneet Ratti, Yongmei Chen, Dinah Misner, Tori Lin, Dimitry Danilenko, Paula Katavolos, Estelle Doudemont, Hirdesh Uppal, Jeffrey Eastham, Judy Mak, Patricia E. de Almeida, Katherine Bao, Azadeh Hadadianpour, Mary Keir, Richard A. D. Carano, Lauri Diehl, Min Xu, Yan Wu, Robby M. Weimer, Jason DeVoss, Wyne P. Lee, Mercedesz Balazs, Kevin Walsh, Kathila R. Alatsis, Flavius Martin, Ali A. Zarrin
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or CSF1-deficient mice have revealed that IL34 function is limited to the central nervous system and sk
Externí odkaz:
https://doaj.org/article/f5bbd900f7f94b86b15fbd853c8ad352
Autor:
Joseph Chavarria-Smith, Cecilia P.C. Chiu, Janet K. Jackman, Jianping Yin, Juan Zhang, Jason A. Hackney, Wei-Yu Lin, Tulika Tyagi, Yonglian Sun, Janet Tao, Debra Dunlap, William D. Morton, Swapnil V. Ghodge, Henry R. Maun, Hong Li, Hilda Hernandez-Barry, Kelly M. Loyet, Emily Chen, John Liu, Christine Tam, Brian L. Yaspan, Hao Cai, Mercedesz Balazs, Joseph R. Arron, Jing Li, Arthur J Wittwer, Rajita Pappu, Cary D. Austin, Wyne P. Lee, Robert A. Lazarus, Jawahar Sudhamsu, James T. Koerber, Tangsheng Yi
Publikováno v:
Science Translational Medicine. 14
The epidermis is a barrier that prevents water loss while keeping harmful substances from penetrating the host. The impermeable cornified layer of the stratum corneum is maintained by balancing continuous turnover driven by epidermal basal cell proli
Autor:
Eleni Amaniti, Nikolay Nikolov, Stephanie Czieso, Cary D. Austin, Abdul Sesay, Sean Flanagan, Dennis Wilson, Christine Clarke, Jessica Mills, Riccardo Guidi, Yi Cao, Mark S. Wilson, Probir Chakravaty, Alison Huynh, Lewis J. Entwistle, Shannon Hambro, Helena Aegerter, Laurie Leong, Victor Nunez, Angela Martzall
Publikováno v:
MUCOSAL IMMUNOLOGY
Mucosal Immunology
Mucosal Immunology
Acute exacerbations (AE) of asthma, remain one of the biggest concerns for patients living with asthma. As such, identifying the causes, the molecular mechanisms involved and new therapeutic interventions to prevent AE is a high priority. Immunity to
Autor:
Ke-Jung Huang, Homer Pantua, Jingyu Diao, Elizabeth Skippington, Michael Volny, Wendy Sandoval, Varnesh Tiku, Yutian Peng, Meredith Sagolla, Donghong Yan, Jing Kang, Anand Kumar Katakam, Nairie Michaelian, Mike Reichelt, Man-Wah Tan, Cary D. Austin, Min Xu, Emily Hanan, Sharookh B. Kapadia
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Acinetobacter baumannii is a clinically important, predominantly health care–associated gram-negative bacterium with high rates of emerging resistance worldwide. Given the urgent need for novel antibacterial therapies against A. baumannii , we focu
Autor:
Kathryn Mesh, Kun Peng, John G. Matthews, Prescott G. Woodruff, Wendy S. Putnam, Melissa Gonzalez Edick, Elliot Israel, Peter Bradding, Margaret Solon, Francis Abreu, Arnaud Bourdin, Kit Wong, Monet Howard, Monica Kraft, Cecile T.J. Holweg, Joseph R. Arron, Cary D. Austin, J. Mark FitzGerald, Gail M. Gauvreau, David F. Choy, Fang Cai, Ronald E. Ferrando, Lief Bjermer, Miriam Baca, Julie Olsson, Clavier Investigators, Kaharu Sumino
Publikováno v:
Clinical and Experimental Allergy
Clinical and Experimental Allergy, Wiley, In press, ⟨10.1111/cea.13731⟩
Clinical and Experimental Allergy, In press, ⟨10.1111/cea.13731⟩
Clinical and Experimental Allergy, Wiley, In press, ⟨10.1111/cea.13731⟩
Clinical and Experimental Allergy, In press, ⟨10.1111/cea.13731⟩
Background The anti-interleukin 13 (IL-13) monoclonal antibody lebrikizumab improves lung function in patients with moderate-to-severe uncontrolled asthma, but its effects on airway inflammation and remodelling are unknown. CLAVIER was designed to as
Autor:
Donghong Yan, Cameron L. Noland, Jingyu Diao, Peter Liu, Anand Kumar Katakam, Mike Reichelt, Haruhiko Ogawa, Cary D. Austin, Susan L. Gloor, Yutian Peng, Min Xu, Hayato Yanagida, Patrick C Reid, Jing Kang, Rie Komura, Homer Pantua, Kelly M. Storek, Yiming Xu, Michael Volny, Wendy Sandoval, Jeremy Murray, Nicholas N. Nickerson, Steven T. Rutherford, Junichi Nishikawa, Tatsuya Sano, Hiroko Inaba, Sharookh B. Kapadia, Christian N. Cunningham
Publikováno v:
Journal of Bacteriology
Lipoprotein diacylglyceryl transferase (Lgt) catalyzes the first step in the biogenesis of Gram-negative bacterial lipoproteins which play crucial roles in bacterial growth and pathogenesis. We demonstrate that Lgt depletion in a clinical uropathogen
Autor:
Jun Chen, Justin Elstrott, Lan Wang, Simon S. Gao, Richard A.D. Carano, Jose E. Heredia, Elisia Villemure, Daniel G. Shore, Wyne P. Lee, Bobby Brillantes, Joseph H. Lin, Liling Liu, David H. Hackos, Jens Kortmann, Matthew Volgraf, Daniel D. Bravo, Christine Tam, Lorena Riol-Blanco, Steven Magnuson, Lionel Rouge, Chris Bjornson, Baihua Hu, Tania Chernov-Rogan, Rebecca M. Reese, Christopher P. Arthur, Min Jung, Michelle Dourado, Xiumin Wu, Victory Joseph, Alberto Estevez, John Liu, Alvin Gogineni, Juan Zhang, Laurie Leong, Jian Payandeh, Vishal Verma, Shannon D. Shields, Han Ting Ding, Brian Safina, Alessia Balestrini, Yong Chen, Vineela D. Gandham, Eric Suto, Jianyong Wang, Justin Ly, Rebecca N. Bauer, Jonas Doerr, Alexis Rohou, Cary D. Austin, Jason A. Vander Heiden, Xiaoying Yang, Ryan L. Wong, Lucinda Tam, Liuxi Chen, Kathy Hötzel, Kai H. Barck, Merone Roose-Girma, Claudio Ciferri, Huifen Chen, Bianca M. Liederer
Publikováno v:
Journal of Experimental Medicine. 218
Despite the development of effective therapies, a substantial proportion of asthmatics continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient receptor potential cation channel member A1 (TRPA1) agonists are elevated