Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Cary D Austin"'
Autor:
Cary M. Looney, MS, Aaron Schroeder, BS, Erica Tavares, BSN, Jay Garg, MD, MBA, Thomas Schindler, PhD, Flavio Vincenti, MD, Robert R. Redfield, MD, Stanley C. Jordan, MD, Stephan Busque, MD, E. Steve Woodle, MD, Jared Khan, MS, Jeffrey Eastham, MS, Sandrine Micallef, PhD, Cary D. Austin, MD, PhD, Alyssa Morimoto, PhD
Publikováno v:
Transplantation Direct, Vol 9, Iss 2, p e1436 (2023)
Background. The THEORY study evaluated the effects of single and multiple doses of obinutuzumab, a type 2 anti-CD20 antibody that induces antibody-dependent cell-mediated cytotoxicity and direct cell death, in combination with standard of care in pat
Externí odkaz:
https://doaj.org/article/10259b2ed34f4a58b4712c88b2dfd5e4
Autor:
Arna Katewa, Eric Suto, Jessica Hui, Jose Heredia, Jie Liang, Jason Hackney, Keith Anderson, Tuija M Alcantar, Natasha Bacarro, Debra Dunlap, Jeffrey Eastham, Andres Paler-Martinez, Xin Y Rairdan, Zora Modrusan, Wyne P Lee, Cary D Austin, Daniel Lafkas, Nico Ghilardi
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0244439 (2021)
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease representing a serious unmet medical need. The disease is associated with the loss of self-tolerance and exaggerated B cell activation, resulting in autoantibody production and the fo
Externí odkaz:
https://doaj.org/article/ed0d04cf471f47d69accfbf3ee12f167
Autor:
Homer Pantua, Elizabeth Skippington, Marie-Gabrielle Braun, Cameron L. Noland, Jingyu Diao, Yutian Peng, Susan L. Gloor, Donghong Yan, Jing Kang, Anand Kumar Katakam, Janina Reeder, Georgette M. Castanedo, Keira Garland, Laszlo Komuves, Meredith Sagolla, Cary D. Austin, Jeremy Murray, Yiming Xu, Zora Modrusan, Min Xu, Emily J. Hanan, Sharookh B. Kapadia
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Clinical development of antibiotics with novel mechanisms of action to kill pathogenic bacteria is challenging, in part, due to the inevitable emergence of resistance. A phenomenon of potential clinical importance that is broadly overlooked
Externí odkaz:
https://doaj.org/article/ad7dc0127d394ca78d233d455e860331
Autor:
Hans D. Brightbill, Eric Suto, Nicole Blaquiere, Nandhini Ramamoorthi, Swathi Sujatha-Bhaskar, Emily B. Gogol, Georgette M. Castanedo, Benjamin T. Jackson, Youngsu C. Kwon, Susan Haller, Justin Lesch, Karin Bents, Christine Everett, Pawan Bir Kohli, Sandra Linge, Laura Christian, Kathy Barrett, Allan Jaochico, Leonid M. Berezhkovskiy, Peter W. Fan, Zora Modrusan, Kelli Veliz, Michael J. Townsend, Jason DeVoss, Adam R. Johnson, Robert Godemann, Wyne P. Lee, Cary D. Austin, Brent S. McKenzie, Jason A. Hackney, James J. Crawford, Steven T. Staben, Moulay H. Alaoui Ismaili, Lawren C. Wu, Nico Ghilardi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Clinical trials of BAFF blockade with belimumab have shown partial efficacy for the treatment of systemic lupus erythematosus (SLE), so other therapeutic options are required. Here, the authors present a new small molecule inhibitor that targets NIK
Externí odkaz:
https://doaj.org/article/c1b21708fc0a4c58b4c58242d9d32c50
Autor:
WeiYu Lin, Daqi Xu, Cary D. Austin, Patrick Caplazi, Kate Senger, Yonglian Sun, Surinder Jeet, Judy Young, Donnie Delarosa, Eric Suto, Zhiyu Huang, Juan Zhang, Donghong Yan, Cesar Corzo, Kai Barck, Sharmila Rajan, Carrie Looney, Vineela Gandham, Justin Lesch, Wei-Ching Liang, Elaine Mai, Hai Ngu, Navneet Ratti, Yongmei Chen, Dinah Misner, Tori Lin, Dimitry Danilenko, Paula Katavolos, Estelle Doudemont, Hirdesh Uppal, Jeffrey Eastham, Judy Mak, Patricia E. de Almeida, Katherine Bao, Azadeh Hadadianpour, Mary Keir, Richard A. D. Carano, Lauri Diehl, Min Xu, Yan Wu, Robby M. Weimer, Jason DeVoss, Wyne P. Lee, Mercedesz Balazs, Kevin Walsh, Kathila R. Alatsis, Flavius Martin, Ali A. Zarrin
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or CSF1-deficient mice have revealed that IL34 function is limited to the central nervous system and sk
Externí odkaz:
https://doaj.org/article/f5bbd900f7f94b86b15fbd853c8ad352
Autor:
Latifa Khalfaoui, Fiona A. Symon, Simon Couillard, Beverley Hargadon, Rekha Chaudhuri, Steve Bicknell, Adel H. Mansur, Rahul Shrimanker, Timothy S. C. Hinks, Ian D. Pavord, Stephen J. Fowler, Vanessa Brown, Lorcan P. McGarvey, Liam G. Heaney, Cary D. Austin, Peter H. Howarth, Joseph R. Arron, David F. Choy, Peter Bradding
Publikováno v:
Khalfaoui, L, Symon, F A, Couillard, S, Hargadon, B, Chaudhuri, R, Bicknell, S, Mansur, A H, Shrimanker, R, Hinks, TS C, Pavord, I D, Fowler, S J, Brown, V, McGarvey, L P, Heaney, L G, Austin, C D, Howarth, P H, Arron, J R, Choy, D F & Bradding, P 2022, ' Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker-high and -low severe asthma ', Allergy . https://doi.org/10.1111/all.15376
UK Medical Research Council Refractory Asthma Stratification programme (RASP-UK) 2022, ' Airway remodelling rather than cellular infiltration characterises both type2 cytokine biomarker-high and-low severe asthma ', Allergy . https://doi.org/10.1111/all.15376
UK Medical Research Council Refractory Asthma Stratification programme (RASP-UK) 2022, ' Airway remodelling rather than cellular infiltration characterises both type2 cytokine biomarker-high and-low severe asthma ', Allergy . https://doi.org/10.1111/all.15376
Background: The most recognizable phenotype of severe asthma comprises people who are blood eosinophil and FeNO-high, driven by type-2 (T2) cytokine biology which responds to targeted biological therapies. However, in many people with severe asthma,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d335eaa0fe9178f81b6b89fe40cd151
https://doi.org/10.1111/all.15376
https://doi.org/10.1111/all.15376
Autor:
Joseph Chavarria-Smith, Cecilia P.C. Chiu, Janet K. Jackman, Jianping Yin, Juan Zhang, Jason A. Hackney, Wei-Yu Lin, Tulika Tyagi, Yonglian Sun, Janet Tao, Debra Dunlap, William D. Morton, Swapnil V. Ghodge, Henry R. Maun, Hong Li, Hilda Hernandez-Barry, Kelly M. Loyet, Emily Chen, John Liu, Christine Tam, Brian L. Yaspan, Hao Cai, Mercedesz Balazs, Joseph R. Arron, Jing Li, Arthur J Wittwer, Rajita Pappu, Cary D. Austin, Wyne P. Lee, Robert A. Lazarus, Jawahar Sudhamsu, James T. Koerber, Tangsheng Yi
Publikováno v:
Science Translational Medicine. 14
The epidermis is a barrier that prevents water loss while keeping harmful substances from penetrating the host. The impermeable cornified layer of the stratum corneum is maintained by balancing continuous turnover driven by epidermal basal cell proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074c597e8e83b2eb94577ed9dd1e5053
https://doi.org/10.1126/scitranslmed.abp9159
https://doi.org/10.1126/scitranslmed.abp9159
Autor:
Ke-Jung Huang, Homer Pantua, Jingyu Diao, Elizabeth Skippington, Michael Volny, Wendy Sandoval, Varnesh Tiku, Yutian Peng, Meredith Sagolla, Donghong Yan, Jing Kang, Anand Kumar Katakam, Nairie Michaelian, Mike Reichelt, Man-Wah Tan, Cary D. Austin, Min Xu, Emily Hanan, Sharookh B. Kapadia
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Acinetobacter baumannii is a clinically important, predominantly health care–associated gram-negative bacterium with high rates of emerging resistance worldwide. Given the urgent need for novel antibacterial therapies against A. baumannii , we focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d0dc82e096281ab4df29647d2a70859
https://doi.org/10.1073/pnas.2123117119
https://doi.org/10.1073/pnas.2123117119
Autor:
Eleni Amaniti, Nikolay Nikolov, Stephanie Czieso, Cary D. Austin, Abdul Sesay, Sean Flanagan, Dennis Wilson, Christine Clarke, Jessica Mills, Riccardo Guidi, Yi Cao, Mark S. Wilson, Probir Chakravaty, Alison Huynh, Lewis J. Entwistle, Shannon Hambro, Helena Aegerter, Laurie Leong, Victor Nunez, Angela Martzall
Publikováno v:
MUCOSAL IMMUNOLOGY
Mucosal Immunology
Mucosal Immunology
Acute exacerbations (AE) of asthma, remain one of the biggest concerns for patients living with asthma. As such, identifying the causes, the molecular mechanisms involved and new therapeutic interventions to prevent AE is a high priority. Immunity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e5f049561e525f5006eb9aa9041a49
https://doi.org/10.1038/s41385-021-00401-x
https://doi.org/10.1038/s41385-021-00401-x
Autor:
Kathryn Mesh, Kun Peng, John G. Matthews, Prescott G. Woodruff, Wendy S. Putnam, Melissa Gonzalez Edick, Elliot Israel, Peter Bradding, Margaret Solon, Francis Abreu, Arnaud Bourdin, Kit Wong, Monet Howard, Monica Kraft, Cecile T.J. Holweg, Joseph R. Arron, Cary D. Austin, J. Mark FitzGerald, Gail M. Gauvreau, David F. Choy, Fang Cai, Ronald E. Ferrando, Lief Bjermer, Miriam Baca, Julie Olsson, Clavier Investigators, Kaharu Sumino
Publikováno v:
Clinical and Experimental Allergy
Clinical and Experimental Allergy, Wiley, In press, ⟨10.1111/cea.13731⟩
Clinical and Experimental Allergy, In press, ⟨10.1111/cea.13731⟩
Clinical and Experimental Allergy, Wiley, In press, ⟨10.1111/cea.13731⟩
Clinical and Experimental Allergy, In press, ⟨10.1111/cea.13731⟩
Background The anti-interleukin 13 (IL-13) monoclonal antibody lebrikizumab improves lung function in patients with moderate-to-severe uncontrolled asthma, but its effects on airway inflammation and remodelling are unknown. CLAVIER was designed to as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e09f921ff0a596f26f42c8645f7cfe
http://europepmc.org/articles/PMC7756263
http://europepmc.org/articles/PMC7756263