C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer's disease.

Autor: Gomez-Arboledas, Angela¹ (AUTHOR), Carvalho, Klebea² (AUTHOR), Balderrama-Gutierrez, Gabriela² (AUTHOR), Chu, Shu-Hui¹ (AUTHOR), Liang, Heidi Yahan² (AUTHOR), Schartz, Nicole D.¹ (AUTHOR), Selvan, Purnika¹ (AUTHOR), Petrisko, Tiffany J.¹ (AUTHOR), Pan, Miranda A.¹ (AUTHOR), Mortazavi, Ali² (AUTHOR), Tenner, Andrea J.^1,3,4 (AUTHOR) atenner@uci.edu

Publikováno v: Acta Neuropathologica Communications. 8/17/2022, Vol. 10 Issue 1, p1-21. 21p.

Additional file 1 of Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression

Autor: Carvalho, Klebea, Schartz, Nicole D., Balderrama-Gutierrez, Gabriela, Liang, Heidi Y., Chu, Shu-Hui, Selvan, Purnika, Gomez-Arboledas, Angela, Petrisko, Tiffany J., Fonseca, Maria I., Mortazavi, Ali, Tenner, Andrea J.

Additional file 1: Fig S1. Presence of the C5aGFAP transgene increases C5a protein levels in brain. Fig S2. Locomotion and exploration during open field and object location memory training at 7 months. Fig S3. C5aR1 ablation reduces dystrophic neurit

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C5aR1 antagonism suppresses inflammatory glial gene expression and alters cellular signaling in an aggressive Alzheimer's model.

Autor: Schartz ND; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA 92697., Liang HY; Department of Developmental & Cell Biology, University of California, Irvine, Irvine, CA 92697., Carvalho K; Department of Developmental & Cell Biology, University of California, Irvine, Irvine, CA 92697., Chu SH; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA 92697., Mendoza-Arvilla A; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA 92697., Petrisko TJ; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA 92697., Gomez-Arboledas A; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA 92697., Mortazavi A; Department of Developmental & Cell Biology, University of California, Irvine, Irvine, CA 92697., Tenner AJ; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA 92697.; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697.; Department of Pathology and Laboratory Medicine, University of California, Irvine, School of Medicine, Irvine, CA 92697.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 22. Date of Electronic Publication: 2023 Aug 22.