Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models

Autor: Bruce J. Aronow, Aaron Topol, Jonathan A. Ellman, Chimezie Ononenyi, Carty Nc, Angus C. Nairn, Ulrich Müller, A. Phillips, Jian Xu, Seok-Man Ho, Christopher Pittenger, Michael W. Nestor, Paul J. Lombroso, Sounak Gupta, Ethan Foscue, Kristen J. Brennand, Tyler D. Baguley, Judith L. Rapoport, Claudia S. Barros, Brigham J. Hartley, Peter Gochman, M. Xu, Pradeep Kurup

Publikováno v: Molecular Psychiatry. 23:271-281

The brain-specific tyrosine phosphatase, STEP (STriatal-Enriched protein tyrosine Phosphatase) is an important regulator of synaptic function. STEP normally opposes synaptic strengthening by increasing N-methyl D-aspartate glutamate receptor (NMDAR)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a729ae213d6a285b1f9f1c77688ceb7e
https://doi.org/10.1038/mp.2016.163

The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications.

Autor: Carty NC; Child Study Center, Yale University School of Medicine, New Haven, CT 06520-7900, USA., Xu J, Kurup P, Brouillette J, Goebel-Goody SM, Austin DR, Yuan P, Chen G, Correa PR, Haroutunian V, Pittenger C, Lombroso PJ

Publikováno v: Translational psychiatry [Transl Psychiatry] 2012 Jul 10; Vol. 2, pp. e137. Date of Electronic Publication: 2012 Jul 10.

Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice.

Autor: Carty NC; Alzheimer's Research Laboratory, Department of Molecular Pharmacology and Physiology, School of Biomedical Sciences, University of South Florida College of Medicine, Tampa, Florida, USA., Nash K; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA., Lee D; Alzheimer's Research Laboratory, Department of Molecular Pharmacology and Physiology, School of Biomedical Sciences, University of South Florida College of Medicine, Tampa, Florida, USA., Mercer M; Alzheimer's Research Laboratory, Department of Molecular Pharmacology and Physiology, School of Biomedical Sciences, University of South Florida College of Medicine, Tampa, Florida, USA., Gottschall PE; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Meyers C; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA., Muzyczka N; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida, USA., Gordon MN; Alzheimer's Research Laboratory, Department of Molecular Pharmacology and Physiology, School of Biomedical Sciences, University of South Florida College of Medicine, Tampa, Florida, USA., Morgan D; Alzheimer's Research Laboratory, Department of Molecular Pharmacology and Physiology, School of Biomedical Sciences, University of South Florida College of Medicine, Tampa, Florida, USA. Electronic address: scientist.dave@gmail.com.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2008 Sep; Vol. 16 (9), pp. 1580-1586. Date of Electronic Publication: 2016 Dec 08.