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Autoradiographic comparison of cholinergic and other transmitter receptors in the normal human hippocampus

Autor: Anthony V. Cheng, Mary Johnson, Nigel J. M. Birdsall, Jonathon T. Turner, Jennifer A. Court, Elaine K. Perry, James A. Edwardson, Robert H. Perry, Carthage J. Smith, Margaret A. Piggott, Janet Kerwin, Victoria James, Christopher Morris

Publikováno v: Hippocampus. 3:307-315

The vulnerability of the human hippocampal complex to disease, trauma, and aging indicates the necessity to target this area therapeutically. The distribution and density of transmitter receptors provide a rational basis for this approach, and in thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7fbb5fc8491f490b090149ce689740
https://doi.org/10.1002/hipo.450030306

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NGF deprivation and neuronal degeneration trigger altered β-amyloid precursor protein gene expression in the rat superior cervical ganglia in vivo and in vitro

Autor: Isabelle Neveu, Patricia A. Osborne, Philippe Brachet, Carthage J. Smith, Eugene M. Johnson, Robert S. Freeman

Publikováno v: Molecular Brain Research. 17:328-334

In order to study the expression of beta-amyloid precursor protein (APP) isoforms during neuronal degeneration we have used the rat superior cervical ganglia (SCG) as an experimental model. In the neonate these sympathetic ganglia are nerve growth fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd058010684f3d8c4c228b3ea00e6de
https://doi.org/10.1016/0169-328x(93)90018-k

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Cholinergic and Dopaminergic Activities in Senile Dementia of Lewy Body Type

Autor: Elaine K. Perry, Elizabeth Marshall, Robert H. Perry, Dorothy Irving, Carthage J. Smith, Garry Blessed, Andrew F. Fairbairn

Publikováno v: Alzheimer Disease & Associated Disorders. 4:87-95

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4d1746169f3738970b747e21629f831
https://doi.org/10.1097/00002093-199040200-00003

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Developmental changes in tau phosphorylation: fetal tau is transiently phosphorylated in a manner similar to paired helical filament-tau characteristic of Alzheimer's disease

Autor: A M Couck, Carthage J. Smith, Brian H. Anderton, Jean Pierre Brion, Jean-Marc Gallo

Publikováno v: Journal of neurochemistry. 61(6)

Rat and human fetal brain tau were probed with a panel of monoclonal antibodies (tau-1, AT8, 8D8, RT97, SMI31, SMI34) that distinguish between paired helical filament (PHF)-tau of Alzheimer's disease and normal adult brain tau. These antibodies discr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73569c3976fd3473594c38a70a6a54c
https://pubmed.ncbi.nlm.nih.gov/8245963

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Nerve growth factor-induced neuronal differentiation is accompanied by differential splicing of beta-amyloid precursor mRNAs in the PC12 cell line

Autor: Carthage J. Smith, Philippe Brachet, Didier Wion

Publikováno v: Brain research. Molecular brain research. 10(4)

The effect of the neurotrophic factor nerve growth factor (NGF) on the expression of the beta-amyloid gene has been studied in the clonal nerve cell line PC12. The neuronal differentiation of PC12 cells in the presence of NGF was accompanied by a shi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f42fd26374f1957c8cdfd28b33dc6d
https://pubmed.ncbi.nlm.nih.gov/1656161

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Evidence of a monoaminergic-cholinergic imbalance related to visual hallucinations in Lewy body dementia

Autor: Elaine K. Perry, Elizabeth F. Marshall, Janet Kerwin, Anthony V. Cheng, Carthage J. Smith, Robert H. Perry, S. Jabeen

Publikováno v: Journal of neurochemistry. 55(4)

Senile dementia of Lewy body type is characterized clinically by a relatively acute onset of fluctuating memory loss and confusion, frequently accompanied by visual hallucinations. Neurochemical analyses of temporal cortex has revealed a distinction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c126e799205ee53a355161cd346fa4
https://pubmed.ncbi.nlm.nih.gov/1697897

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Cholinergic nicotinic and muscarinic receptors in dementia of Alzheimer, Parkinson and Lewy body types

Autor: J.A. Court, Robert H. Perry, Carthage J. Smith, Elaine K. Perry

Publikováno v: Journal of neural transmission. Parkinson's disease and dementia section. 2(3)

Cholinergic nicotinic and muscarinic receptor binding were measured in post mortem human brain tissue, using low (nM) concentrations of (3H)-nicotine to detect predominately the high affinity nicotinic site and (3H)-N-methylscopolamine in the presenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360fbac47e8c5912a7ec992fab4a9106
https://pubmed.ncbi.nlm.nih.gov/2175197

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