Výsledky vyhledávání - "Cartha W. Naylor"

Overlapping molecular signaling of IRX-2 and Ta1 resulting in synergistic biological activity

Publikováno v: Expert opinion on biological therapy. 18(sup1)

With the recent approvals of immune therapies such as checkpoint inhibitors and chimeric antigen receptor cell therapy, the development of immune modulators for cancer therapy has been given new li...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd261812b4b50a1e3a913820e79d6419
https://pubmed.ncbi.nlm.nih.gov/29792763

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Utilization of HPLC-Elisa to Assess Serum Levels of Thymosin α1Following Subcutaneous Administration to Human Subjects

Autor: Cartha W. Naylor, D. Sasaki, Paul H. Naylor, Milton G. Mutchnick

Publikováno v: Journal of Liquid Chromatography. 17:3541-3551

Thymosin α1 (Tα1) is a 28 aa peptide which is prepared synthetically for clinical use in settings where an immune modulating peptide is predicted to have efficacy. With the increase in clinical stu...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4331918b2daeaf6617ae2d402fc84e4
https://doi.org/10.1080/10826079408013530

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Identification of immunoreactive forms of thymosin α1 in serum and supernatants by combining HPLC and RIA

Autor: Allan L. Goldstein, Cartha W. Naylor, Karen K. Oates, Marcia C. Coss, Paul H. Naylor, Michael R. Erdos

Publikováno v: International Journal of Immunopharmacology. 14:1267-1278

Thymosin alpha 1 (T alpha 1) is a biologically active peptide, originally isolated from the thymus and currently undergoing clinical trials as an immunomodulator in cancer patients, in individuals with chronic active hepatitis, and as an immunoenhanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40fc31b7002b99bec7f1078ec727d030
https://doi.org/10.1016/0192-0561(92)90063-q

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Oral administration of interferon-alpha induces a transient decline in oral mucosal immunoglobulins and an increase in interleukin-5

Autor: Cartha W. Naylor, Susan Hendrix, Francis G. LeVeque, Paul H. Naylor

Publikováno v: Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 19(8)

Although administration of interferon-alpha (IFN-alpha) via the oral-mucosal route has shown efficacy in a variety of human and animal diseases, the mechanism of action of orally administered IFN is not clearly understood. To assess the possibility t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838b3dd84165d0a5ec0006966e5f5275
https://pubmed.ncbi.nlm.nih.gov/10476943

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Thymosin alpha 1 does not promote growth or oncogenic transformation

Autor: Mitchell R. Smith, Cartha W. Naylor, Magdalena Skunca, Jeffrey A. Moshier, Julie Dosescu, Paul H. Naylor, Milton G. Mutchnick

Publikováno v: International journal of immunopharmacology. 18(5)

Thymosin alpha 1 (T alpha 1) is an immune modulatory peptide which has been evaluated in a variety of clinical trials. Although no in vivo adverse effects, including enhancement of tumor growth, have been noted, in vitro studies suggesting a role for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dcc9352525107fe7e97155011a0d702
https://pubmed.ncbi.nlm.nih.gov/8933211

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Improved ELISA to measure thymosin α1: Comparison of whole and absorbed antisera

Autor: Paul H. Naylor, Seiji Wada, Cartha W. Naylor, Allan L. Goldstein

Publikováno v: International Journal of Immunopharmacology. 10:795-801

An improved microELISA to measure thymosin alpha 1 (T alpha 1) is described which uses a rabbit antibody against T alpha 1 that has been absorbed with a synthetic C-14 fragment of T alpha 1. This assay is compared to the previous assay which used the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d88c64c5e51824d53c570614965c6e
https://doi.org/10.1016/0192-0561(88)90002-1

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Human immunodeficiency virus contains an epitope immunoreactive with thymosin alpha 1 and the 30-amino acid synthetic p17 group-specific antigen peptide HGP-30

Autor: Allan L. Goldstein, Prem S. Sarin, Arthur Thornton, Seiji Wada, Cartha W. Naylor, Paul H. Naylor, Daisy K. Sun, Su-Sun Wang, Mahnaz Badamchian

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 84(9)

We have reported that an antiserum prepared against thymosin alpha 1 [which shares a region of homology with the p17 protein of the acquired immunodeficiency syndrome (AIDS)-associated human immunodeficiency virus] effectively neutralized the AIDS vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e978363f16b4e67ac38200ebb0ed899b
https://pubmed.ncbi.nlm.nih.gov/2437588

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