Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Carter J. Wilson"'
Autor:
Ahmed Salem, Carter J. Wilson, Benjamin S. Rutledge, Allison Dilliott, Sali Farhan, Wing-Yiu Choy, Martin L. Duennwald
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the degeneration of both upper and lower motor neurons in the brain and spinal cord. ALS is associated with protein misfolding and inclusion formation involving RNA-
Externí odkaz:
https://doaj.org/article/863c8b1a8e9c4e4fb7ca720b95b26d33
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4591 (2022)
The development of AlphaFold2 marked a paradigm-shift in the structural biology community. Herein, we assess the ability of AlphaFold2 to predict disordered regions against traditional sequence-based disorder predictors. We find that AlphaFold2 perfo
Externí odkaz:
https://doaj.org/article/dfeba1ee40bc4c8e87f2b4ef159b790a
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5408 (2021)
We have performed 280 μs of unbiased molecular dynamics (MD) simulations to investigate the effects of 12 different cancer mutations on Kelch-like ECH-associated protein 1 (KEAP1) (G333C, G350S, G364C, G379D, R413L, R415G, A427V, G430C, R470C, R470H
Externí odkaz:
https://doaj.org/article/40eb99b03e96467da4bf87c9e74ed199
In a protein, nearby titratable sites can be coupled: the (de)protonation of one may affect the other. The degree of this interaction depends on several factors and can influence the measured pKa. Here, we derive a formalism based on double free ener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8955c61ef7fc13ede220309b8ab1da7e
https://doi.org/10.26434/chemrxiv-2023-1c8rn
https://doi.org/10.26434/chemrxiv-2023-1c8rn
The development of AlphaFold2 was a paradigm-shift in the structural biology community; herein we assess the ability of AlphaFold2 to predict disordered regions against traditional sequence-based disorder predictors. We find that a näaive use of Dic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cc550547372d72650ab41879d53133c
https://doi.org/10.1101/2021.09.27.461910
https://doi.org/10.1101/2021.09.27.461910
Publikováno v:
Chemistry Publications
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5408, p 5408 (2021)
Volume 22
Issue 10
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5408, p 5408 (2021)
Volume 22
Issue 10
We have performed 280 μs of unbiased molecular dynamics (MD) simulations to investigate the effects of 12 different cancer mutations on Kelch-like ECH-associated protein 1 (KEAP1) (G333C, G350S, G364C, G379D, R413L, R415G, A427V, G430C, R470C, R470H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c0d73b2a7e3a06d3ef6347df3d8405
https://ir.lib.uwo.ca/context/chempub/article/1207/viewcontent/pdf.pdf
https://ir.lib.uwo.ca/context/chempub/article/1207/viewcontent/pdf.pdf
Autor:
Nadun Chanaka Karunatilleke, Wing-Yiu Choy, Carter J Wilson, Mikko Karttunen, Mohamed Hesham Moselhy, Megan Chang
Publikováno v:
Chemistry Publications
The nuclear factor erythroid 2-related factor 2 (Nrf2)-ARE transcriptional response pathway plays a critical role in protecting the cell from oxidative stresses via the upregulation of cytoprotective genes. Aberrant activation of Nrf2 in cancer cells