Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Carter J Swanson"'
Autor:
Elizabeth A Germino, Joseph P Miller, Lauri Diehl, Carter J Swanson, Steffen Durinck, Zora Modrusan, Jeffrey H Miner, Andrey S Shaw
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194998 (2018)
Given the frequency with which MAP kinase signaling is dysregulated in cancer, much effort has been focused on inhibiting RAS signaling for therapeutic benefit. KSR1, a pseudokinase that interacts with RAF, is a potential target; it was originally cl
Externí odkaz:
https://doaj.org/article/e95cebb71d8944dd9688b9c793cac23d
Autor:
Carter J Swanson, Ruth F Sommese, Karl J Petersen, Michael Ritt, Joshua Karslake, David D Thomas, Sivaraj Sivaramakrishnan
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0162331 (2016)
Protein kinase C α (PKCα) is a nodal regulator in several intracellular signaling networks. PKCα is composed of modular domains that interact with each other to dynamically regulate spatial-temporal function. We find that PKCα specifically, rapid
Externí odkaz:
https://doaj.org/article/cc4b07610da745a192461515a767abe7
Publikováno v:
Journal of Biological Chemistry. 292:2873-2880
Resolving the conformational dynamics of large multidomain proteins has proven to be a significant challenge. Here we use a variety of techniques to dissect the roles of individual protein kinase Cα (PKCα) regulatory domains in maintaining catalyti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f62c652d2c7bc2c7d70f3b1c26691b
https://doi.org/10.1074/jbc.m116.768457
https://doi.org/10.1074/jbc.m116.768457
Autor:
Meron Mengistu, Susan S. Taylor, Andrey S. Shaw, Joshua D. Webster, Carter J. Swanson, Daniel M. Whalen, John G. Quinn, Saravanan Raju, Kim Newton
Publikováno v:
Science signaling. 11(544)
Necroptosis, an inflammatory form of cell death, is initiated by the activation of receptor-interacting protein kinase 3 (RIPK3), which depends on its interaction with RIPK1. Although catalytically inactive, the RIPK3 mutant D161N still stimulates RI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635a762d73d26370d99fec93005ec667
https://pubmed.ncbi.nlm.nih.gov/30131368
https://pubmed.ncbi.nlm.nih.gov/30131368
Autor:
Carter J. Swanson, Lauri Diehl, Zora Modrusan, Jeffrey H. Miner, Steffen Durinck, Andrey S. Shaw, Elizabeth Germino, Joseph P. Miller
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 3, p e0194998 (2018)
PLoS ONE, Vol 13, Iss 3, p e0194998 (2018)
Given the frequency with which MAP kinase signaling is dysregulated in cancer, much effort has been focused on inhibiting RAS signaling for therapeutic benefit. KSR1, a pseudokinase that interacts with RAF, is a potential target; it was originally cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ebb35738c38720615d641278eb07ff
http://europepmc.org/articles/PMC5875795
http://europepmc.org/articles/PMC5875795
Autor:
Jung Hwa Cho, Carter J. Swanson, Kasey Rose, Cheng-Ming Chuong, Ang Li, Robert H. Chow, Shannon E. Boye, Jeannie Chen, Lisa G. Lippert, Sivaraj Sivaramakrishnan
Publikováno v:
ACS chemical biology. 12(4)
We report on GCaMP-Rs, a new family of genetically encoded ratiometric calcium indicators that extend the virtues of the GCaMP proteins to ratiometric measurements. We have engineered a tandem construct of calcium-dependent GCaMP and calcium-independ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95194981b00728ea03fb598548dda8cb
https://pubmed.ncbi.nlm.nih.gov/28195691
https://pubmed.ncbi.nlm.nih.gov/28195691
Autor:
Megan J. Peterson, David J. Culpepper, Melissa A. Hale, Joseph J. Ban, Benjamin J. McFarland, Erin C. Dunnington, Samuel H. Henager, Carter J. Swanson, Nicholas J. Maurice, Lisa K. Sanders, Luke D. Davies
Publikováno v:
Protein Science. 21:1396-1402
We redesigned residues on the surface of MICA, a protein that binds the homodimeric immunoreceptor NKG2D, to increase binding affinity with a series of rational, incremental changes. A fixed-backbone RosettaDesign protocol scored a set of initial mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fcd5abd25b317f6d4281ca4a87d9962
https://doi.org/10.1002/pro.2115
https://doi.org/10.1002/pro.2115
Publikováno v:
The Journal of biological chemistry. 289(37)
The α-helix is a ubiquitous secondary structural element that is almost exclusively observed in proteins when stabilized by tertiary or quaternary interactions. However, beginning with the unexpected observations of α-helix formation in the isolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec162c760c20e6eb88fd4c7d9d8e5ed0
https://pubmed.ncbi.nlm.nih.gov/25059657
https://pubmed.ncbi.nlm.nih.gov/25059657
Autor:
Carter J. Swanson, Mike Ritt, Margaret V. Westfall, William S.-Y. Wang, Barath Udarasayan, Sivaraj Sivaramakrishnan
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5af58654e285ee53f55e7fe755ab20c0
https://doi.org/10.1096/fasebj.27.1_supplement.597.3
https://doi.org/10.1096/fasebj.27.1_supplement.597.3
Autor:
Joshua Karslake, David D. Thomas, Karl J. Petersen, Sivaraj Sivaramakrishnan, Michael Ritt, Ruth F. Sommese, Carter J. Swanson
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 10, p e0162331 (2016)
PLoS ONE, Vol 11, Iss 10, p e0162331 (2016)
Protein kinase C α (PKCα) is a nodal regulator in several intracellular signaling networks. PKCα is composed of modular domains that interact with each other to dynamically regulate spatial-temporal function. We find that PKCα specifically, rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761f831f34521e3f375e452803a47fa0
https://doi.org/10.1371/journal.pone.0162331
https://doi.org/10.1371/journal.pone.0162331