Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Carter Diggs"'
Autor:
Julie Healer, Jennifer K. Thompson, Karen L. Mackwell, Cecille D. Browne, Benjamin A. Seager, Anna Ngo, Kym N. Lowes, Sarah E. Silk, David Pulido, Lloyd D. W. King, Jayne M. Christen, Amy R. Noe, Vinayaka Kotraiah, Paul J. Masendycz, Rajkannan Rajagopalan, Leanne Lucas, Marianne M. Stanford, Lorraine Soisson, Carter Diggs, Robin Miller, Susan Youll, Kaye Wycherley, Simon J. Draper, Alan F. Cowman
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
BackgroundRH5 is the leading vaccine candidate for the Plasmodium falciparum blood stage and has shown impact on parasite growth in the blood in a human clinical trial. RH5 binds to Ripr and CyRPA at the apical end of the invasive merozoite form, and
Externí odkaz:
https://doaj.org/article/84dce22671ea4ea78f35e3a24b9607b4
Autor:
Marvin J Sklar, Santina Maiolatesi, Noelle Patterson, Martha Sedegah, Keith Limbach, Nimfa Teneza-Mora, Ilin Chuang, K Monique Hollis-Perry, Jo Glenna Banania, Ivelese Guzman, Harini Ganeshan, Sharina Reyes, Michael R Hollingdale, Mimi Wong, Ashley Lindstrom, Anatalio Reyes, Yolanda Alcorta, Lindsey Garver, Kelli Bankard, Arnel Belmonte, Maria Belmonte, Jun Huang, Kalpana Gowda, Sandra Inoue, Rachel Velasco, Elke Bergmann-Leitner, Jack Hutter, Tida Lee, Nehkonti Adams, Sidhartha Chaudhury, Devin Hunt, Cindy Tamminga, Eleanor Berrie, Duncan Bellamy, Mustapha Bittaye, Katie Ewer, Carter Diggs, Lorraine A Soisson, Alison Lawrie, Adrian Hill, Thomas L Richie, Eileen Villasante, Judith E Epstein, Christopher A Duplessis
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0256980 (2021)
BackgroundA DNA-prime/human adenovirus serotype 5 (HuAd5) boost vaccine encoding Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP) and Pf apical membrane antigen-1 (PfAMA1), elicited protection in 4/15 (27%) of subjects against controlled h
Externí odkaz:
https://doaj.org/article/4dc547617946467c9611eaa99d4458b4
Autor:
Prakash Srinivasan, G. Christian Baldeviano, Kazutoyo Miura, Ababacar Diouf, Julio A. Ventocilla, Karina P. Leiva, Luis Lugo-Roman, Carmen Lucas, Sachy Orr-Gonzalez, Daming Zhu, Eileen Villasante, Lorraine Soisson, David L. Narum, Susan K. Pierce, Carole A. Long, Carter Diggs, Patrick E. Duffy, Andres G. Lescano, Louis H. Miller
Publikováno v:
npj Vaccines, Vol 2, Iss 1, Pp 1-10 (2017)
Malaria: Inhibiting parasite invasion of red blood cells A vaccine targeting a protein complex that allows malaria-causing parasite to enter red blood cells has been produced. Malaria caused by the parasite Plasmodium falciparum is an oft-deadly infe
Externí odkaz:
https://doaj.org/article/d9c88e0c86564a8eab352c28fd19d3b2
Autor:
Matthew B Laurens, Bourema Kouriba, Elke Bergmann-Leitner, Evelina Angov, Drissa Coulibaly, Issa Diarra, Modibo Daou, Amadou Niangaly, William C Blackwelder, Yukun Wu, Joe Cohen, W Ripley Ballou, Johan Vekemans, David E Lanar, Sheetij Dutta, Carter Diggs, Lorraine Soisson, D Gray Heppner, Ogobara K Doumbo, Christopher V Plowe, Mahamadou A Thera
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173294 (2017)
The blood-stage malaria vaccine FMP2.1/AS02A, comprised of recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1) and the adjuvant system AS02A, had strain-specific efficacy against clinical malaria caused by P. falciparum with the vaccin
Externí odkaz:
https://doaj.org/article/6d13068d77704a0982ced7606e6c4c8b
Autor:
Martha Sedegah, Bjoern Peters, Michael R Hollingdale, Harini D Ganeshan, Jun Huang, Fouzia Farooq, Maria N Belmonte, Arnel D Belmonte, Keith J Limbach, Carter Diggs, Lorraine Soisson, Ilin Chuang, Eileen D Villasante
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168952 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0163026.].
Externí odkaz:
https://doaj.org/article/6b983bf99ade498c9ea42ff970a9130d
Autor:
Martha Sedegah, Bjoern Peters, Michael R Hollingdale, Harini D Ganeshan, Jun Huang, Fouzia Farooq, Maria N Belmonte, Arnel D Belmonte, Keith J Limbach, Carter Diggs, Lorraine Soisson, Ilin Chuang, Eileen D Villasante
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163026 (2016)
A DNA prime/adenovirus boost malaria vaccine encoding Plasmodium falciparum strain 3D7 CSP and AMA1 elicited sterile clinical protection associated with CD8+ T cell interferon-gamma (IFN-γ) cells responses directed to HLA class 1-restricted AMA1 epi
Externí odkaz:
https://doaj.org/article/b470eba925ad48b885ae0f2ae4826e2b
Autor:
Martha Sedegah, Michael R Hollingdale, Fouzia Farooq, Harini Ganeshan, Maria Belmonte, Yohan Kim, Bjoern Peters, Alessandro Sette, Jun Huang, Shannon McGrath, Esteban Abot, Keith Limbach, Meng Shi, Lorraine Soisson, Carter Diggs, Ilin Chuang, Cindy Tamminga, Judith E Epstein, Eileen Villasante, Thomas L Richie
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106241 (2014)
Fifteen volunteers were immunized with three doses of plasmid DNA encoding P. falciparum circumsporozoite protein (CSP) and apical membrane antigen-1 (AMA1) and boosted with human adenovirus-5 (Ad) expressing the same antigens (DNA/Ad). Four voluntee
Externí odkaz:
https://doaj.org/article/18fd91dbeb06455b990df603f7c226dd
Autor:
Ilin Chuang, Martha Sedegah, Susan Cicatelli, Michele Spring, Mark Polhemus, Cindy Tamminga, Noelle Patterson, Melanie Guerrero, Jason W Bennett, Shannon McGrath, Harini Ganeshan, Maria Belmonte, Fouzia Farooq, Esteban Abot, Jo Glenna Banania, Jun Huang, Rhonda Newcomer, Lisa Rein, Dianne Litilit, Nancy O Richie, Chloe Wood, Jittawadee Murphy, Robert Sauerwein, Cornelus C Hermsen, Andrea J McCoy, Edwin Kamau, James Cummings, Jack Komisar, Awalludin Sutamihardja, Meng Shi, Judith E Epstein, Santina Maiolatesi, Donna Tosh, Keith Limbach, Evelina Angov, Elke Bergmann-Leitner, Joseph T Bruder, Denise L Doolan, C Richter King, Daniel Carucci, Sheetij Dutta, Lorraine Soisson, Carter Diggs, Michael R Hollingdale, Christian F Ockenhouse, Thomas L Richie
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55571 (2013)
Gene-based vaccination using prime/boost regimens protects animals and humans against malaria, inducing cell-mediated responses that in animal models target liver stage malaria parasites. We tested a DNA prime/adenovirus boost malaria vaccine in a Ph
Externí odkaz:
https://doaj.org/article/29ce14248ad349cd876816870b787f25
Autor:
Martha Sedegah, Cindy Tamminga, Shannon McGrath, Brent House, Harini Ganeshan, Jennylynn Lejano, Esteban Abot, Glenna J Banania, Renato Sayo, Fouzia Farooq, Maria Belmonte, Nalini Manohar, Nancy O Richie, Chloe Wood, Carole A Long, David Regis, Francis T Williams, Meng Shi, Ilin Chuang, Michele Spring, Judith E Epstein, Jose Mendoza-Silveiras, Keith Limbach, Noelle B Patterson, Joseph T Bruder, Denise L Doolan, C Richter King, Lorraine Soisson, Carter Diggs, Daniel Carucci, Sheetij Dutta, Michael R Hollingdale, Christian F Ockenhouse, Thomas L Richie
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e24586 (2011)
Models of immunity to malaria indicate the importance of CD8+ T cell responses for targeting intrahepatic stages and antibodies for targeting sporozoite and blood stages. We designed a multistage adenovirus 5 (Ad5)-vectored Plasmodium falciparum mala
Externí odkaz:
https://doaj.org/article/9c9a093b9e1d42e4bfd2af438749573f
Autor:
Cindy Tamminga, Martha Sedegah, David Regis, Ilin Chuang, Judith E Epstein, Michele Spring, Jose Mendoza-Silveiras, Shannon McGrath, Santina Maiolatesi, Sharina Reyes, Victoria Steinbeiss, Charlotte Fedders, Kathryn Smith, Brent House, Harini Ganeshan, Jennylynn Lejano, Esteban Abot, Glenna J Banania, Renato Sayo, Fouzia Farooq, Maria Belmonte, Jittawadee Murphy, Jack Komisar, Jackie Williams, Meng Shi, Donald Brambilla, Nalini Manohar, Nancy O Richie, Chloe Wood, Keith Limbach, Noelle B Patterson, Joseph T Bruder, Denise L Doolan, C Richter King, Carter Diggs, Lorraine Soisson, Daniel Carucci, Gail Levine, Sheetij Dutta, Michael R Hollingdale, Christian F Ockenhouse, Thomas L Richie
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25868 (2011)
A protective malaria vaccine will likely need to elicit both cell-mediated and antibody responses. As adenovirus vaccine vectors induce both these responses in humans, a Phase 1/2a clinical trial was conducted to evaluate the efficacy of an adenoviru
Externí odkaz:
https://doaj.org/article/97a1ce60fb5e4006ae377a92a4081a31