Stepping dynamics of dynein characterized by MINFLUX.

Autor: Slivka J; Department of Physics, University of California at Berkeley, Berkeley CA 94720 USA., Gleave E; Medical Research Council Laboratory of Molecular Biology, Division of Structural Studies, Francis Crick Avenue, Cambridge, CB2 0QH, UK., Wijewardena DP; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana IL 61801 USA., Canty JT; Biophysics Graduate Group, University of California at Berkeley, Berkeley CA 94720 USA., Selvin PR; Department of Physics, University of Illinois at Urbana-Champaign, Urbana IL 61801 USA., Carter AP; Medical Research Council Laboratory of Molecular Biology, Division of Structural Studies, Francis Crick Avenue, Cambridge, CB2 0QH, UK., Yildiz A; Department of Physics, University of California at Berkeley, Berkeley CA 94720 USA.; Biophysics Graduate Group, University of California at Berkeley, Berkeley CA 94720 USA.; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720 USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 18. Date of Electronic Publication: 2024 Jul 18.

Molecular mechanism of dynein-dynactin complex assembly by LIS1.

Autor: Singh K; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK., Lau CK; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK., Manigrasso G; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK., Gama JB; Instituto de Investigação e Inovação em Saúde (i3S)/Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4200-135 Porto, Portugal., Gassmann R; Instituto de Investigação e Inovação em Saúde (i3S)/Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4200-135 Porto, Portugal., Carter AP; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Mar 29; Vol. 383 (6690), pp. eadk8544. Date of Electronic Publication: 2024 Mar 29.

A force-sensitive mutation reveals a spindle assembly checkpoint-independent role for dynein in anaphase progression.

Autor: Salvador-Garcia D; Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Jin L; Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Hensley A; Department of Physics, University of California at Berkeley, Berkeley, CA 94720, USA., Gölcük M; Department of Mechanical Engineering, Istanbul Technical University, Istanbul, 34437, Turkey., Gallaud E; Institut de Génétique et Développement de Rennes - UMR 6290, Université de Rennes, F-35000 Rennes, France., Chaaban S; Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Port F; Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.; Current address: Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Vagnoni A; Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.; Current address: Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9RX, UK., Planelles-Herrero VJ; Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., McClintock MA; Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Derivery E; Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Carter AP; Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Giet R; Institut de Génétique et Développement de Rennes - UMR 6290, Université de Rennes, F-35000 Rennes, France., Gür M; Department of Mechanical Engineering, Istanbul Technical University, Istanbul, 34437, Turkey.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA., Yildiz A; Department of Physics, University of California at Berkeley, Berkeley, CA 94720, USA.; Department of Molecular and Cellular Biology, University of California at Berkeley, Berkeley, CA 94720, USA., Bullock SL; Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 04. Date of Electronic Publication: 2023 Aug 04.

Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin.

Autor: d'Amico EA; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany., Ud Din Ahmad M; Oncode Institute and Department of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Cmentowski V; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany.; Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Girbig M; MRC Laboratory of Molecular Biology, Cambridge, UK., Müller F; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany., Wohlgemuth S; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany., Brockmeyer A; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Dortmund, Germany., Maffini S; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany., Janning P; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Dortmund, Germany., Vetter IR; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany., Carter AP; MRC Laboratory of Molecular Biology, Cambridge, UK., Perrakis A; Oncode Institute and Department of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Musacchio A; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany.; Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.

Publikováno v: The Journal of cell biology [J Cell Biol] 2022 Nov 07; Vol. 221 (11). Date of Electronic Publication: 2022 Sep 15.

SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope.

Autor: He P; State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.; University of Chinese Academy of Science, Beijing, China., Liu B; State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Gao X; Bioland Laboratory (Guangzhou Regenerative Medicine and Health - Guangdong Laboratory), Guangzhou, China., Yan Q; State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Pei R; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China., Sun J; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Chen Q; Bioland Laboratory (Guangzhou Regenerative Medicine and Health - Guangdong Laboratory), Guangzhou, China., Hou R; State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.; University of Chinese Academy of Science, Beijing, China.; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China., Li Z; State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Zhang Y; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Zhao J; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Sun H; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China., Feng B; School of Biomedical Sciences, Huaqiao University, Quanzhou, China., Wang Q; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Yi H; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Hu P; State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Li P; State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Zhang Y; State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.; University of Chinese Academy of Science, Beijing, China., Chen Z; School of Biomedical Sciences, Huaqiao University, Quanzhou, China.; Xiamen United Institute of Respiratory Health, Xiamen, China., Niu X; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Zhong X; Bioland Laboratory (Guangzhou Regenerative Medicine and Health - Guangdong Laboratory), Guangzhou, China., Jin L; Bioland Laboratory (Guangzhou Regenerative Medicine and Health - Guangdong Laboratory), Guangzhou, China., Liu X; Angitia Biopharmaceuticals, Guangzhou, China., Qu K; Infectious Diseases Translational Research Programme, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ciazynska KA; Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Carter AP; Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Briggs JAG; Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.; Max Planck Institute of Biochemistry, Martinsried, Germany., Chen J; State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.; Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong Province, China., Liu J; State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China., Chen X; State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. chen_xinwen@gibh.ac.cn.; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. chen_xinwen@gibh.ac.cn.; Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong Province, China. chen_xinwen@gibh.ac.cn., He J; State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. he_jun@gibh.ac.cn.; Bioland Laboratory (Guangzhou Regenerative Medicine and Health - Guangdong Laboratory), Guangzhou, China. he_jun@gibh.ac.cn., Chen L; State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. chen_ling@gibh.ac.cn.; Bioland Laboratory (Guangzhou Regenerative Medicine and Health - Guangdong Laboratory), Guangzhou, China. chen_ling@gibh.ac.cn.; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China. chen_ling@gibh.ac.cn.; Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong Province, China. chen_ling@gibh.ac.cn., Xiong X; State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. xiong_xiaoli@gibh.ac.cn.; Bioland Laboratory (Guangzhou Regenerative Medicine and Health - Guangdong Laboratory), Guangzhou, China. xiong_xiaoli@gibh.ac.cn.

Publikováno v: Nature microbiology [Nat Microbiol] 2022 Oct; Vol. 7 (10), pp. 1635-1649. Date of Electronic Publication: 2022 Sep 23.