Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Carsten Zothner"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes febrile disease, muscle and joint pain, which can become chronic in some individuals. The non-structural protein 3 (nsP3) plays essential roles during infection, but a complete u
Externí odkaz:
https://doaj.org/article/cfce921af4d1466292623637d73e7a2c
Autor:
Jacqueline Farinha Shimizu, Carina Machado Pereira, Cintia Bittar, Mariana Nogueira Batista, Guilherme Rodrigues Fernandes Campos, Suely da Silva, Adélia Cristina Oliveira Cintra, Carsten Zothner, Mark Harris, Suely Vilela Sampaio, Victor Hugo Aquino, Paula Rahal, Ana Carolina Gomes Jardim
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187857 (2017)
Hepatitis C virus (HCV) is one of the main causes of liver disease and transplantation worldwide. Current therapy is expensive, presents additional side effects and viral resistance has been described. Therefore, studies for developing more efficient
Externí odkaz:
https://doaj.org/article/907aba9c846c44c48af3451eee3bc17c
Autor:
Jacqueline Farinha Shimizu, Shiraz Feferbaum-Leite, Igor Andrade Santos, Daniel Oliveira Silva Martins, Natalie J. Kingston, Mona Shegdar, Carsten Zothner, Suely Vilela Sampaio, Mark Harris, Nicola J. Stonehouse, Ana Carolina Gomes Jardim
Publikováno v:
International Journal of Biological Macromolecules. 241:124519
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::578da06a1d289d6478d6fb588b773d93
https://doi.org/10.1016/j.ijbiomac.2023.124519
https://doi.org/10.1016/j.ijbiomac.2023.124519
Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches?
Autor:
Ana Carolina Gomes Jardim, Jacqueline Farinha Shimizu, Daniel Oliveira Silva Martins, Andres Merits, Mark Harris, Martin J. McPhillie, Grace C. Roberts, Carsten Zothner
Publikováno v:
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2020-12-10T17:35:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-07-01 Royal Society - Newton Advanced Fellowship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61c143136f24f6972e79430b8b57d89
https://pubmed.ncbi.nlm.nih.gov/32333884
https://pubmed.ncbi.nlm.nih.gov/32333884
Autor:
Roland, Remenyi, Yanni, Gao, Ruth E, Hughes, Alistair, Curd, Carsten, Zothner, Michelle, Peckham, Andres, Merits, Mark, Harris
Publikováno v:
Journal of Virology
Chikungunya virus (CHIKV) is a reemerging alphavirus transmitted by mosquitos and causes transient sickness but also chronic disease affecting muscles and joints. No approved vaccines or antivirals are available. Thus, a better understanding of the v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11326d968cd709424b12b209b638e9b8
https://pubmed.ncbi.nlm.nih.gov/29875241
https://pubmed.ncbi.nlm.nih.gov/29875241
Autor:
Hartmut Rokos, Nicholas C.J. Gibbons, Derek J. Maitland, Carsten Zothner, Katharina Rübsam, Bhaven Chavan, John M. Wood, Karin U. Schallreuter
Publikováno v:
Journal of Investigative Dermatology. 128(4):808-815
Patients with the depigmentation disorder vitiligo have low catalase expression/activities and constantly accumulate 10 −3 M hydrogen peroxide (H 2 O 2 ) in their skin. Such high concentrations of H 2 O 2 oxidize L-methionine residues in proteins a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8408bf7f6f512885263ef5bf6936bf2
Autor:
Souna M. Elwary, John M. Wood, Karin U. Schallreuter, Carsten Zothner, Hartmut Rokos, Nicholas C.J. Gibbons
Publikováno v:
Biochemical and Biophysical Research Communications. 349:931-938
The human epidermis holds the capacity for autocrine cholinergic signal transduction, but the presence of butyrylcholinesterase (BchE) has not been shown so far. Our results demonstrate that this compartment transcribes a functional BchE. Its activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb2356ccc8b84bfcb276ffd1947a6b8
https://doi.org/10.1016/j.bbrc.2006.08.138
https://doi.org/10.1016/j.bbrc.2006.08.138
Autor:
Bhaven Chavan, Jennifer D. Spencer, John M. Wood, Karin U. Schallreuter, Carsten Zothner, Johanna M. Gillbro, Katharina Rübsam
Publikováno v:
Biochemical and Biophysical Research Communications. 342:145-152
Oxidation of methionine residues by reactive oxygen (ROS) in protein structures leads to the formation of methionine sulfoxide which can consequently lead to a plethora of impaired functionality. The generation of methionine sulfoxide yields ultimate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9364f4b237d25fbeda4101f381346003
https://doi.org/10.1016/j.bbrc.2006.01.124
https://doi.org/10.1016/j.bbrc.2006.01.124
Autor:
Richard A. Urbanowicz, Carsten Zothner, Mark Harris, Jonathan K. Ball, C. Patrick McClure, Timothy P. Hickling, William L. Irving, Mohamed R. Hamed, Christopher P. Mason, Anders Krarup, Alexander W. Tarr, Richard J. C. Brown
L-ficolin is a soluble pattern recognition molecule expressed by the liver that contributes to innate immune defense against microorganisms. It is well described that binding of L-ficolin to specific pathogen-associated molecular patterns activates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebb66bc6a20e60ca3dec42af46480a0
Autor:
John M. Wood, Karin U. Schallreuter, Carsten Zothner, M.M. Abou Elloof, Nicholas C.J. Gibbons
Publikováno v:
Biochemical and biophysical research communications. 360(1)
Patients with acute vitiligo have low epidermal catalase expression/activities and accumulate 10(-3) M H(2)O(2). One consequence of this severe oxidative stress is an altered calcium homeostasis in epidermal keratinocytes and melanocytes. Here, we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7389873d5e36c5052d89ce75a44dbee0
https://pubmed.ncbi.nlm.nih.gov/17592724
https://pubmed.ncbi.nlm.nih.gov/17592724