Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Carsten Wiuf"'
Autor:
Linard Hoessly, Carsten Wiuf
Publikováno v:
Mathematical Biosciences and Engineering, Vol 19, Iss 3, Pp 2720-2749 (2022)
We consider stochastic reaction networks modeled by continuous-time Markov chains. Such reaction networks often contain many reactions, potentially occurring at different time scales, and have unknown parameters (kinetic rates, total amounts). This m
Externí odkaz:
https://doaj.org/article/ed89f2960dbd43ccad4ee311caccef08
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 2, Pp 551-566 (2018)
The detection of ancient gene flow between human populations is an important issue in population genetics. A common tool for detecting ancient admixture events is the D-statistic. The D-statistic is based on the hypothesis of a genetic relationship t
Externí odkaz:
https://doaj.org/article/d11cba82479e49d8bd099bb0b7a2f8d8
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 10, p e1005751 (2017)
Mathematical modelling has become an established tool for studying the dynamics of biological systems. Current applications range from building models that reproduce quantitative data to identifying systems with predefined qualitative features, such
Externí odkaz:
https://doaj.org/article/56b6b94e1ae0473bb8f41c171c5479ee
Publikováno v:
BioTechniques, Vol 43, Iss 6, Pp 756-762 (2007)
Single nucleotide polymorphisms (SNPs) are highly abundant in the genome and especially useful in the search for disease susceptibility genes via population-based association or linkage studies. Therefore, there is a strong need for high throughput a
Externí odkaz:
https://doaj.org/article/9f192c33b65a42f89f6aa2f25082869e
Autor:
Bjørn P Pedersen, Georgiana Ifrim, Poul Liboriussen, Kristian B Axelsen, Michael G Palmgren, Poul Nissen, Carsten Wiuf, Christian N S Pedersen
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85139 (2014)
BackgroundStructured Logistic Regression (SLR) is a newly developed machine learning tool first proposed in the context of text categorization. Current availability of extensive protein sequence databases calls for an automated method to reliably cla
Externí odkaz:
https://doaj.org/article/1ca32674a916416281ef7f72a391c25f
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 11, p e1003322 (2013)
Achieving a complete understanding of cellular signal transduction requires deciphering the relation between structural and biochemical features of a signaling system and the shape of the signal-response relationship it embeds. Using explicit analyti
Externí odkaz:
https://doaj.org/article/e8cf14fe23284a9896dd98f2576e519a
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19670 (2011)
The space of possible protein structures appears vast and continuous, and the relationship between primary, secondary and tertiary structure levels is complex. Protein structure comparison and classification is therefore a difficult but important tas
Externí odkaz:
https://doaj.org/article/736c9f926c0d474e80ba9b68fd920fab
Autor:
Bo Eskerod Madsen, Eliana Marisa Ramos, Mathieu Boulard, Katarzyna Duda, Jens Overgaard, Marianne Nordsmark, Carsten Wiuf, Lise Lotte Hansen
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2492 (2008)
UNLABELLED: THE BACKGROUND: Ribonuclease L (RNASEL), encoding the 2'-5'-oligoadenylate (2-5A)-dependent RNase L, is a key enzyme in the interferon induced antiviral and anti-proliferate pathway. Mutations in RNASEL segregate with the disease in prost
Externí odkaz:
https://doaj.org/article/83d544ed2bf0488bb892bda0023305e9
Autor:
Michael Knudsen, Carsten Wiuf
Publikováno v:
Journal of Applied Mathematics, Vol 2008 (2008)
A Markov chain approach to the study of randomly grown graphs is proposed and applied to some popular models that have found use in biology and elsewhere. For most randomly grown graphs used in biology, it is not known whether the graph or properties
Externí odkaz:
https://doaj.org/article/9c8a27bc42dc49fb8f7ef2b5964c8f73
Autor:
Oliver Ratmann, Ole Jørgensen, Trevor Hinkley, Michael Stumpf, Sylvia Richardson, Carsten Wiuf
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 11, p e230 (2007)
Gene duplication with subsequent interaction divergence is one of the primary driving forces in the evolution of genetic systems. Yet little is known about the precise mechanisms and the role of duplication divergence in the evolution of protein netw
Externí odkaz:
https://doaj.org/article/238978a6b37e4c6290f9c6985fbccd42