Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Carsten Willam"'
Autor:
Charlotte Gaupp, Benjamin Schmid, Philipp Tripal, Aurélie Edwards, Christoph Daniel, Stefan Zimmermann, Margarete Goppelt-Struebe, Carsten Willam, Seymour Rosen, Gunnar Schley
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Functional and structural alterations of peritubular capillaries (PTCs) are a major determinant of chronic kidney disease (CKD). Using a software-based algorithm for semiautomatic segmentation and morphometric quantification, this study anal
Externí odkaz:
https://doaj.org/article/d556644488c64dfabdd56ca82c5dd2ca
Autor:
Andrea Hartner, Thomas Dambietz, Nada Cordasic, Carsten Willam, Nicolai Burzlaff, Martin Brötsch, Christoph Daniel, Mario Schiffer, Kerstin Amann, Roland Veelken, Gunnar Schley, Karl F. Hilgers
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: We previously reported that malignant hypertension is associated with impaired capillary density of target organs. Here, we tested the hypothesis that stabilization of hypoxia-inducible factor (HIF) in a modified “preconditioning” a
Externí odkaz:
https://doaj.org/article/7997124573e846008fb374f54a3b24a4
Autor:
Philipp Steininger, Larissa Herbst, Karl Bihlmaier, Carsten Willam, Sixten Körper, Hubert Schrezenmeier, Harald Klüter, Frederick Pfister, Kerstin Amann, Sabrina Weiss, Detlev H. Krüger, Robert Zimmermann, Klaus Korn, Jörg Hofmann, Thomas Harrer
Publikováno v:
Microorganisms, Vol 11, Iss 2, p 283 (2023)
Puumala hantavirus (PUUV) infections usually show a mild or moderate clinical course, but may sometimes also lead to life-threatening disease. Here, we report on a 60-year-old female patient with common variable immunodeficiency (CVID) who developed
Externí odkaz:
https://doaj.org/article/8c3910faef0a498b84b0087fc53d95dd
Autor:
Helena Stockmann, Theresa Keller, Stefan Büttner, Achim Jörres, Detlef Kindgen-Milles, Julius Valentin Kunz, Josef Leebmann, Claudia Spies, Karl Träger, Sascha Treskatsch, Alexander Uhrig, Carsten Willam, Philipp Enghard, Torsten Slowinski, for the CytoResc Trial Investigators
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-3 (2020)
Abstract Objectives Approximately 8 - 10 % of COVID-19 patients present with a serious clinical course and need for hospitalization, 8% of hospitalized patients need ICU-treatment. Currently, no causal therapy is available and treatment is purely sup
Externí odkaz:
https://doaj.org/article/4f91044807734d2e804f0157dd7993a3
Autor:
Gunnar Schley, Jutta Jordan, Stephan Ellmann, Seymour Rosen, Kai-Uwe Eckardt, Michael Uder, Carsten Willam, Tobias Bäuerle
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218876 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0200259.].
Externí odkaz:
https://doaj.org/article/12efe58d5a3540b590142a4ea417b30a
Autor:
Isabel Siegert, Johannes Schödel, Manfred Nairz, Valentin Schatz, Katja Dettmer, Christopher Dick, Joanna Kalucka, Kristin Franke, Martin Ehrenschwender, Gunnar Schley, Angelika Beneke, Jörg Sutter, Matthias Moll, Claus Hellerbrand, Ben Wielockx, Dörthe M. Katschinski, Roland Lang, Bruno Galy, Matthias W. Hentze, Peppi Koivunen, Peter J. Oefner, Christian Bogdan, Günter Weiss, Carsten Willam, Jonathan Jantsch
Publikováno v:
Cell Reports, Vol 13, Iss 10, Pp 2048-2055 (2015)
Both hypoxic and inflammatory conditions activate transcription factors such as hypoxia-inducible factor (HIF)-1α and nuclear factor (NF)-κB, which play a crucial role in adaptive responses to these challenges. In dendritic cells (DC), lipopolysacc
Externí odkaz:
https://doaj.org/article/b4339f05c39641aab5b3a0a03e4c6afe
Autor:
Gunnar Schley, Jutta Jordan, Stephan Ellmann, Seymour Rosen, Kai-Uwe Eckardt, Michael Uder, Carsten Willam, Tobias Bäuerle
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200259 (2018)
OBJECTIVES:In human chronic kidney disease (CKD) the extent of renal tubulointerstitial fibrosis correlates with progressive loss of renal function. However, fibrosis can so far only be assessed by histology of kidney biopsies. Magnetic resonance ima
Externí odkaz:
https://doaj.org/article/a4c0ee25a12b4c34a2827e0d221879c9
Autor:
Gunnar Schley, Carmen Köberle, Ekaterina Manuilova, Sandra Rutz, Christian Forster, Michael Weyand, Ivan Formentini, Rosemarie Kientsch-Engel, Kai-Uwe Eckardt, Carsten Willam
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145042 (2015)
New renal biomarkers measured in urine promise to increase specificity for risk stratification and early diagnosis of acute kidney injury (AKI) but concomitantly may be altered by urine concentration effects and chronic renal insufficiency. This stud
Externí odkaz:
https://doaj.org/article/d6803c2206584ec89f9a98c052f5d0f9
Autor:
Michael Emeis, Josef Sonntag, Carsten Willam, Evelyn Strauss, Matthias M. Walka, Michael Obladen
Publikováno v:
Mediators of Inflammation, Vol 7, Iss 6, Pp 417-420 (1998)
We investigated the in vitro effect of different form s of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 μ mol/ml blood) or lactic acid (5.5 μ mol/ml) to heparin blood
Externí odkaz:
https://doaj.org/article/afb32647cf35447aa72de8d4c4dc4ca8
Autor:
Ruth E Schietke, Thomas Hackenbeck, Maxine Tran, Regina Günther, Bernd Klanke, Christina L Warnecke, Karl X Knaup, Deepa Shukla, Christian Rosenberger, Robert Koesters, Sebastian Bachmann, Peter Betz, Gunnar Schley, Johannes Schödel, Carsten Willam, Thomas Winkler, Kerstin Amann, Kai-Uwe Eckardt, Patrick Maxwell, Michael S Wiesener
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e31034 (2012)
The Hypoxia-inducible transcription Factor (HIF) represents an important adaptive mechanism under hypoxia, whereas sustained activation may also have deleterious effects. HIF activity is determined by the oxygen regulated α-subunits HIF-1α or HIF-2
Externí odkaz:
https://doaj.org/article/cf57eedd2a284375914bfd92fcd3be7f