Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Carsten Schwarz"'
Autor:
Nils Wetzstein, Margo Diricks, Thomas B. Anton, Sönke Andres, Martin Kuhns, Thomas A. Kohl, Carsten Schwarz, Astrid Lewin, Jan Kehrmann, Barbara C. Kahl, Annika Schmidt, Stefan Zimmermann, Moritz K. Jansson, Sophie A. Baron, Bettina Schulthess, Michael Hogardt, Inna Friesen, Stefan Niemann, Thomas A. Wichelhaus
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background The Mycobacterium avium complex (MAC) comprises the most frequent non-tuberculous mycobacteria (NTM) in Central Europe and currently includes twelve species. M. avium (MAV), M. intracellulare subsp. intracellulare (MINT), and M. i
Externí odkaz:
https://doaj.org/article/0025c604a5664fa7a912d8c3114d1435
Autor:
Barry J Plant, Daniel Peckham, Pierre-Régis Burgel, Alan Smyth, Andreas Jung, Manfred Ballmann, Giovanni Taccetti, Harry Heijerman, Pavel Drevinek, Jochen G Mainz, Carsten Schwarz
Publikováno v:
BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)
The major cause of mortality in people with cystic fibrosis (pwCF) is progressive lung disease characterised by acute and chronic infections, the accumulation of mucus, airway inflammation, structural damage and pulmonary exacerbations. The prevalenc
Externí odkaz:
https://doaj.org/article/ce777e645bdb4ad08771fda0a6783f30
Autor:
Anna Maria Oschmann-Kadenbach, Christoph Schaudinn, Leonard Borst, Carsten Schwarz, Katharina Konrat, Mardjan Arvand, Astrid Lewin
Publikováno v:
International Journal of Medical Microbiology, Vol 314, Iss , Pp 151603- (2024)
Mycobacteroides abscessus is one of the most resistant bacteria so far known and causes severe and hard to treat lung infections in predisposed patients such as those with Cystic Fibrosis (CF). Further, it causes nosocomial infections by forming biof
Externí odkaz:
https://doaj.org/article/60e2f9614f72402eade5e57165ffb67f
Autor:
Jochen G. Mainz, Anton Barucha, Pu Huang, Lilith Bechinger, Franziska Duckstein, Louise Polte, Pauline Sadrieh, Lutz Nährlich, Olaf Eickmeier, Suzanne Van Dullemen, Patience Eschenhagen, Carsten Schwarz, Stefan Lüth, Carlos Zagoya, Ute Graepler-Mainka
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Elexacaftor–tezacaftor–ivacaftor (ETI) is a novel, highly effective CFTR modulator combination proven to enhance lung function and body weight in people with cystic fibrosis (pwCF) carrying a F508del mutation. Recently, we revealed si
Externí odkaz:
https://doaj.org/article/658abcaaf09940f9aee5d184e373a9e4
Autor:
Sivagurunathan Sutharsan, Stefanie Dillenhoefer, Matthias Welsner, Florian Stehling, Folke Brinkmann, Manuel Burkhart, Helmut Ellemunter, Anna-Maria Dittrich, Christina Smaczny, Olaf Eickmeier, Matthias Kappler, Carsten Schwarz, Sarah Sieber, Susanne Naehrig, Lutz Naehrlich, Klaus Tenbrock, Claus Pfannenstiel, Dirk Steffen, Jochen Meister, Britta Welzenbach, Anette Scharschinger, Markus Kratz, Maike Pincus, Tobias Tenenbaum, Mirjam Stahl, Kerstin Landwehr, Stefanie Dillenhöfer, Hans Kössel, Petra Kaiser, Manfred Käding, Simone Stolz, Stefan Blaas, Jutta Hammermann, Monika Gappa, Antje Schuster, Dana Spittel, Sabine Zirlik, Sabina Schmitt, Joachim Bargon, Malte Cremer, Sebastian Fähndrich, Andrea Heinzmann, Lutz Nährlich, Stefan Kuhnert, Sebastian Schmidt, Bettina Wollschläger, Anna Nolde, Inka Held, Wolfgang Kamin, Felix C. Ringshausen, Sabine Wege, Olaf Sommerburg, Norbert Geier, Sara Lisa Fleser, Heinrike Wilkens, Michael Lorenz, Paul Vöhringer, Martin Schebek, Christian Timke, Ingrid Bobis, Thomas Nüßlein, Doris Dieninghoff, Ernst Rietschel, Bastian Klinkhammer, Freerk Prenzel, Alexandra Wald, Axel Kempa, Eva Lücke, Ines Adams, Krystyna Poplawska, Simone Lehmkühler, Monika Bauck, Anne Pfülb, Rainald Fischer, Gudrun Schopper, Susanne Nährig, Matthias Griese, Jörg Grosse, Peter Küster, Birte KinderHolger Köster, Susanne Büsing, Margarethe Pohl, Andreas Artlich, Alexander Kiefer, Manfred Ballmann, Nikola Gjorgjevski, Markus A. Rose, Friederike Ruf, Rolf Mahlberg, Wolfgang Thomas, Ute Graepler, Sebastian Bode, hilipp Meyn, Josef Rosenecker, Cordula Koerner, Klaus-Michael Keller, Tina Teßmer, Helge Hebestreit, Gerhild Lohse
Publikováno v:
The Lancet Regional Health. Europe, Vol 32, Iss , Pp 100690- (2023)
Summary: Background: Treatment with elexacaftor/tezacaftor/ivacaftor (ETI) improves multiple clinical outcomes in people with cystic fibrosis (pwCF) with at least one F508del allele. This study evaluated the real-world impact of ETI on lung function,
Externí odkaz:
https://doaj.org/article/cb7f1132ad9145b4909f1a838def4b95
Autor:
Michaela Lackner, Annika Rössler, André Volland, Marlena Nastassja Stadtmüller, Brigitte Müllauer, Zoltan Banki, Johannes Ströhle, Angela Luttick, Jennifer Fenner, Bettina Sarg, Leopold Kremser, Paul Tone, Heribert Stoiber, Dorothee von Laer, Thorsten Wolff, Carsten Schwarz, Markus Nagl
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1293-1307 (2022)
N-chlorotaurine (NCT) a long-lived oxidant generated by leukocytes, can be synthesized chemically and applied topically as an anti-infective to different body sites, including the lung via inhalation. Here, we demonstrate the activity of NCT against
Externí odkaz:
https://doaj.org/article/c1744b89167b4226b655059ac9a4c53d
Autor:
Patience N. Eschenhagen, Petra Bacher, Claudia Grehn, Jochen G. Mainz, Alexander Scheffold, Carsten Schwarz
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Together with impaired mucociliary clearance, lung disease in cystic fibrosis (CF) is driven by dysregulation of innate and adaptive immunity caused by dysfunctional CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), leading to a
Externí odkaz:
https://doaj.org/article/09cb2c66fa0b4caa98b0e6a7897dbe5a
Autor:
Jochen G. Mainz, Carlos Zagoya, Louise Polte, Lutz Naehrlich, Lenny Sasse, Olaf Eickmeier, Christina Smaczny, Anton Barucha, Lilith Bechinger, Franziska Duckstein, Ludwik Kurzidim, Patience Eschenhagen, Laura Caley, Daniel Peckham, Carsten Schwarz
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/fdf445ccbf604305b8dbc4b1e0461e15
Autor:
Carsten Schwarz, Patience Eschenhagen, Henrijette Schmidt, Thordis Hohnstein, Christina Iwert, Claudia Grehn, Jobst Roehmel, Eva Steinke, Mirjam Stahl, Laura Lozza, Ekaterina Tikhonova, Elisa Rosati, Ulrik Stervbo, Nina Babel, Jochen G. Mainz, Hilmar Wisplinghoff, Frank Ebel, Lei-Jie Jia, Matthew G. Blango, Peter Hortschansky, Sascha Brunke, Bernhard Hube, Axel A. Brakhage, Olaf Kniemeyer, Alexander Scheffold, Petra Bacher
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
BACKGROUND The fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). Th cells orchestrate immune responses against fungi, but the types of A. fumigatus–specific Th cells in pwCF and their cont
Externí odkaz:
https://doaj.org/article/952a35bb46204b4d99016140937e7c30
Autor:
Astrid Lewin, Elisabeth Kamal, Torsten Semmler, Katja Winter, Sandra Kaiser, Hubert Schäfer, Lei Mao, Patience Eschenhagen, Claudia Grehn, Jennifer Bender, Carsten Schwarz
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 2415-2429 (2021)
Mycobacterium (M.) abscessus infections in Cystic Fibrosis (CF) patients cause a deterioration of lung function. Treatment of these multidrug-resistant pathogens is associated with severe side-effects, while frequently unsuccessful. Insight on M. abs
Externí odkaz:
https://doaj.org/article/0f2081c8922a48828890383cafb62789