Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Carsten Schultz-Fademrecht"'
Autor:
Lena Quambusch, Laura Depta, Ina Landel, Melissa Lubeck, Tonia Kirschner, Jonas Nabert, Niklas Uhlenbrock, Jörn Weisner, Michael Kostka, Laura M. Levy, Carsten Schultz-Fademrecht, Franziska Glanemann, Kristina Althoff, Matthias P. Müller, Jens T. Siveke, Daniel Rauh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Elucidating specific effects of protein kinase Akt isoforms remains challenging. Here, the authors establish an Akt isoform-dependent cellular model system and use it, together with X-ray crystallography and structure-based ligand design, to develop
Externí odkaz:
https://doaj.org/article/e9d5b9b56b6e4d8f9a3489c70c876e8e
Autor:
Björn Papke, Sandip Murarka, Holger A Vogel, Pablo Martín-Gago, Marija Kovacevic, Dina C Truxius, Eyad K Fansa, Shehab Ismail, Gunther Zimmermann, Kaatje Heinelt, Carsten Schultz-Fademrecht, Alaa Al Saabi, Matthias Baumann, Peter Nussbaumer, Alfred Wittinghofer, Herbert Waldmann, Philippe I.H. Bastiaens
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
PDEδ is a widely expressed factor that sustains the spatial organization and signalling of Ras family proteins. Here the authors describe the activity of Deltazinone 1, a new highly selective PDEδ inhibitor of KRAS-dependent cancer cell growth with
Externí odkaz:
https://doaj.org/article/98e07183cd0647cabef2a5d6074729d8
Autor:
Jonas Lategahn, Hannah L. Tumbrink, Carsten Schultz-Fademrecht, Alena Heimsoeth, Lisa Werr, Janina Niggenaber, Marina Keul, Fatma Parmaksiz, Matthias Baumann, Sascha Menninger, Eldar Zent, Ina Landel, Jörn Weisner, Kirujan Jeyakumar, Leonie Heyden, Nicole Russ, Fabienne Müller, Carina Lorenz, Johannes Brägelmann, Inga Spille, Tobias Grabe, Matthias P. Müller, Johannes M. Heuckmann, Bert M. Klebl, Peter Nussbaumer, Martin L. Sos, Daniel Rauh
Publikováno v:
Journal of Medicinal Chemistry. 65:6643-6655
Despite the clinical efficacy of epidermal growth factor receptor (EGFR) inhibitors, a subset of patients with non-small cell lung cancer displays insertion mutations in exon20 in EGFR and Her2 with limited treatment options. Here, we present the dev
Autor:
Janina Niggenaber, Matthias Baumann, Sebastian Bauer, Heiko Muller, Tobias Grabe, Jan G. Hengstler, Marina Keul, Luke Hodson, Georgia Günther, Anke Unger, Bernhard Blank-Landeshammer, Daniel Rauh, Alena Heimsoeth, Hannah L. Tumbrink, Julia Ketzer, Christopher Golz, Matthias P. Müller, René P. Zahedi, Carsten Strohmann, Wolf Hiller, Julian Engel, Willem A. L. van Otterlo, Julia Hardick, Philip Klövekorn, Jonas Lategahn, Maren Flaßhoff, Laxmikanth Kollipara, Carsten Schultz-Fademrecht, Thomas Mühlenberg
Publikováno v:
Chemical science, 10:10789
Chemical Science
Chemical Science
We present inhibitors of drug resistant mutants of EGFR including T790M and C797S. In addition, we present the first X-ray crystal structures of covalent inhibitors in complex with C797S-mutated EGFR to gain insight into their binding mode.
Prec
Prec
Autor:
Ulrich Lücking, Jan Dürig, Michael Möllmann, Axel Choidas, Joachim R. Göthert, Roze Imsak, Ulrich Dührsen, Anke Unger, Carsten Schultz-Fademrecht, Maria Göbel, Arne Scholz, Stefanie Kesper, Bert Klebl, Jan Eickhoff, Matthias Baumann
Publikováno v:
Oncotarget
Onset of progression even during therapy with novel drugs remains an issue in chronic lymphocytic leukemia (CLL). Thus, there is ongoing demand for novel agents. Approaches targeting cyclin-dependent kinases (CDK) have reached the clinical trial stag
Autor:
Carsten Schultz-Fademrecht, Heiko Müller, Jonas Lategahn, Julian Engel, Elisabeth Hennes, Anke Unger, Hannah L. Tumbrink, Daniel Rauh, Georgia Günther, Steven Smith, Christian Becker, Matthias Baumann, Marina Keul, Jan G. Hengstler, Lisa Goebel
Publikováno v:
Journal of Medicinal Chemistry. 60:7725-7744
Reversible epidermal growth factor receptor (EGFR) inhibitors prompt a beneficial clinical response in non-small cell lung cancer patients who harbor activating mutations in EGFR. However, resistance mutations, particularly the gatekeeper mutation T7
Autor:
Bert Klebl, Hans R. Schöler, Herbert Waldmann, Matthias Baumann, Gisbert Schneider, Jared Sterneckert, Lea Kremer, Susanne Kordes, Peter Habenberger, Carsten Schultz-Fademrecht, Slava Ziegler, Axel Choidas
Publikováno v:
Angewandte Chemie International Edition. 56:13021-13025
Cell-based assays enable monitoring of small-molecule bioactivity in a target-agnostic manner and help uncover new biological mechanisms. Subsequent identification and validation of the small-molecule targets, typically employing proteomics technique
Autor:
Stephan A. Hahn, Niklas Dienstbier, Julia Hardick, Swetlana Ladigan, Anke Unger, Jan G. Hengstler, Heiner Wolters, Niklas Uhlenbrock, Heiko Muller, Rajesh Gontla, Daniel Rauh, Rebekka Scheinpflug, Richard Viebahn, Carsten Schultz-Fademrecht, Ina Landel, Lena Quambusch, Jens T. Siveke, Georgia Günther, Andrea Tannapfel, Jörn Weisner, Marius Lindemann, Marija Trajkovic-Arsic, Laura Depta, Matthias Baumann, Abdelouahid Maghnouj, Steven Smith, Christian Teschendorf, Michael Pohl, Matthias P. Müller, Christoph Reintjes, Waldemar Uhl
Aberrations within the PI3K/AKT signaling axis are frequently observed in numerous cancer types, highlighting the relevance of these pathways in cancer physiology and pathology. However, therapeutic interventions employing AKT inhibitors often suffer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba0bcaa4694c09b5e756cb17289057e
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85065516542
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85065516542
Autor:
René P. Zahedi, Julia Ketzer, Daniel Rauh, Christian Becker, Sebastian Bauer, Carsten Schultz-Fademrecht, Marina Keul, Jonas Lategahn, Laxmikanth Kollipara, Thomas Mühlenberg, Julian Engel
Publikováno v:
Angewandte Chemie. 128:11069-11073
Autor:
Paula Porras, Zakk Walterscheid, Dawn Jaquish, Jan Eickhoff, Michele L. Babicky, Evangeline Mose, Jeffery Chakedis, Andrew M. Lowy, Peter Cheng, Carsten Schultz-Fademrecht, Oliver Schadt, Randall French, Haleigh Howard, Christina Esdar, Jaclyn Miyamoto, Patrick Holman
Publikováno v:
Oncotarget
// Jeffery Chakedis 1 , Randall French 1 , Michele Babicky 1 , Dawn Jaquish 1 , Evangeline Mose 1 , Peter Cheng 1 , Patrick Holman 1 , Haleigh Howard 1 , Jaclyn Miyamoto 1 , Paula Porras 1 , Zakk Walterscheid 1 , Carsten Schultz-Fademrecht 2 , Christ