Zobrazeno 1 - 10
of 498
pro vyhledávání: '"Carsten Schultz"'
Publikováno v:
Implementation Science, Vol 19, Iss 1, Pp 1-29 (2024)
Abstract Background Clinical decision support systems (CDSSs) have the potential to improve quality of care, patient safety, and efficiency because of their ability to perform medical tasks in a more data-driven, evidence-based, and semi-autonomous w
Externí odkaz:
https://doaj.org/article/040eebd2acd045fba8014c69bbac4dd5
Publikováno v:
BMC Musculoskeletal Disorders, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background Patella fractures account for approximately 1% of all skeletal injuries. Treatment options are vast and no definitive conclusion on what option is the most beneficial could be made so far. Plate osteosynthesis appears to gain in i
Externí odkaz:
https://doaj.org/article/023f74945e2f4796834a4a8a7f3503fa
Autor:
Karen Vester, Marco Preußner, Nicole Holton, Suihan Feng, Carsten Schultz, Florian Heyd, Markus C. Wahl
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Through the use of a reversible chemical dimerizer, the splicing factor PRPF38A is re-localized to the nuclear lamina, paving the way for a systematic analysis of spatio-temporal splicing regulation.
Externí odkaz:
https://doaj.org/article/ffdc066451914e1eaef33cc842e71134
Autor:
Scotland E. Farley, Jennifer E. Kyle, Hans C. Leier, Lisa M. Bramer, Jules B. Weinstein, Timothy A. Bates, Joon-Yong Lee, Thomas O. Metz, Carsten Schultz, Fikadu G. Tafesse
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Here, Farley et al. perform untargeted lipidomics to assess how SARS-CoV-2 rewires host lipid metabolism. SARS-CoV-2 viral proteins specifically induce lipid droplet formation and dramatically change lipid metabolism to support infection; interfering
Externí odkaz:
https://doaj.org/article/8045e4b0f34b44b689fa4b922259ce55
Autor:
Lena Quambusch, Laura Depta, Ina Landel, Melissa Lubeck, Tonia Kirschner, Jonas Nabert, Niklas Uhlenbrock, Jörn Weisner, Michael Kostka, Laura M. Levy, Carsten Schultz-Fademrecht, Franziska Glanemann, Kristina Althoff, Matthias P. Müller, Jens T. Siveke, Daniel Rauh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Elucidating specific effects of protein kinase Akt isoforms remains challenging. Here, the authors establish an Akt isoform-dependent cellular model system and use it, together with X-ray crystallography and structure-based ligand design, to develop
Externí odkaz:
https://doaj.org/article/e9d5b9b56b6e4d8f9a3489c70c876e8e
Autor:
Asli D. Yildirim, Mevlut Citir, Asli E. Dogan, Zehra Veli, Zehra Yildirim, Ozlem Tufanli, Alexis Traynor-Kaplan, Carsten Schultz, Ebru Erbay
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 10, Pp 100279- (2022)
The unfolded protein response (UPR) is an elaborate signaling network that evolved to maintain proteostasis in the endoplasmic reticulum (ER) and mitochondria (mt). These organelles are functionally and physically associated, and consequently, their
Externí odkaz:
https://doaj.org/article/978a54790e714435803d399ad90aff41
Autor:
Dario L. Frey, Calum Bridson, Susanne Dittrich, Simon Y. Graeber, Mirjam Stahl, Sabine Wege, Felix Herth, Olaf Sommerburg, Carsten Schultz, Alexander Dalpke, Marcus A. Mall, Sébastien Boutin
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Airway inflammation and microbiome dysbiosis are hallmarks of cystic fibrosis (CF) lung disease. However, longitudinal studies are needed to decipher which factors contribute to the long-term evolution of these key features of CF. We therefore evalua
Externí odkaz:
https://doaj.org/article/65502817e3db49e7af9bc03cefffacf8
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0276204 (2022)
Open data platforms are interfaces between data demand of and supply from their users. Yet, data platform providers frequently struggle to aggregate data to suit their users' needs and to establish a high intensity of data exchange in a collaborative
Externí odkaz:
https://doaj.org/article/c6bfb195d4c04d3a95aeb1c602f2b723
Publikováno v:
Physiological Reports, Vol 10, Iss 1, Pp n/a-n/a (2022)
Abstract ATP has been previously identified as an autocrine signaling factor that is co‐released with insulin to modulate and propagate β‐cell activity within islets of Langerhans. Here, we show that β‐cell activity and insulin secretion esse
Externí odkaz:
https://doaj.org/article/3b76d38b2a744bcf941e589c711656cb
Autor:
Claudius Wagner, Anita Balázs, Jolanthe Schatterny, Zhe Zhou-Suckow, Julia Duerr, Carsten Schultz, Marcus A. Mall
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13405 (2022)
Elevated levels of matrix metalloprotease 9 (MMP-9) and neutrophil elastase (NE) are associated with bronchiectasis and lung function decline in patients with cystic fibrosis (CF). MMP-9 is a potent extracellular matrix-degrading enzyme which is acti
Externí odkaz:
https://doaj.org/article/d6a50689cdbf46afa217f3335933d512