Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Carsten Sachse"'
Autor:
Berk Küçükoğlu, Inayathulla Mohammed, Ricardo C. Guerrero-Ferreira, Stephanie M. Ribet, Georgios Varnavides, Max Leo Leidl, Kelvin Lau, Sergey Nazarov, Alexander Myasnikov, Massimo Kube, Julika Radecke, Carsten Sachse, Knut Müller-Caspary, Colin Ophus, Henning Stahlberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Cryo-transmission electron microscopy (cryo-EM) of frozen hydrated specimens is an efficient method for the structural analysis of purified biological molecules. However, cryo-EM and cryo-electron tomography are limited by the low signal-to-
Externí odkaz:
https://doaj.org/article/561d8052cab546c7bd91c70e0853b4c4
Autor:
Gerard J. Kleywegt, Paul D. Adams, Sarah J. Butcher, Catherine L. Lawson, Alexis Rohou, Peter B. Rosenthal, Sriram Subramaniam, Maya Topf, Sanja Abbott, Philip R. Baldwin, John M. Berrisford, Gérard Bricogne, Preeti Choudhary, Tristan I. Croll, Radostin Danev, Sai J. Ganesan, Timothy Grant, Aleksandras Gutmanas, Richard Henderson, J. Bernard Heymann, Juha T. Huiskonen, Andrei Istrate, Takayuki Kato, Gabriel C. Lander, Shee-Mei Lok, Steven J. Ludtke, Garib N. Murshudov, Ryan Pye, Grigore D. Pintilie, Jane S. Richardson, Carsten Sachse, Osman Salih, Sjors H. W. Scheres, Gunnar F. Schroeder, Carlos Oscar S. Sorzano, Scott M. Stagg, Zhe Wang, Rangana Warshamanage, John D. Westbrook, Martyn D. Winn, Jasmine Y. Young, Stephen K. Burley, Jeffrey C. Hoch, Genji Kurisu, Kyle Morris, Ardan Patwardhan, Sameer Velankar
Publikováno v:
IUCrJ, Vol 11, Iss 2, Pp 140-151 (2024)
In January 2020, a workshop was held at EMBL-EBI (Hinxton, UK) to discuss data requirements for the deposition and validation of cryoEM structures, with a focus on single-particle analysis. The meeting was attended by 47 experts in data processing, m
Externí odkaz:
https://doaj.org/article/0e43f020fe4a4894b6f5aa6a5fd3dc2f
Autor:
Nikolas Furthmann, Verian Bader, Lena Angersbach, Alina Blusch, Simran Goel, Ana Sánchez-Vicente, Laura J. Krause, Sarah A. Chaban, Prerna Grover, Victoria A. Trinkaus, Eva M. van Well, Maximilian Jaugstetter, Kristina Tschulik, Rune Busk Damgaard, Carsten Saft, Gisa Ellrichmann, Ralf Gold, Arend Koch, Benjamin Englert, Ana Westenberger, Christine Klein, Lisa Jungbluth, Carsten Sachse, Christian Behrends, Markus Glatzel, F. Ulrich Hartl, Ken Nakamura, Chadwick W. Christine, Eric J. Huang, Jörg Tatzelt, Konstanze F. Winklhofer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract NEMO is a ubiquitin-binding protein which regulates canonical NF-κB pathway activation in innate immune signaling, cell death regulation and host-pathogen interactions. Here we identify an NF-κB-independent function of NEMO in proteostasis
Externí odkaz:
https://doaj.org/article/254c39b4dc224a428f4f65c841b52060
Autor:
Daniel Mann, Simon A. Fromm, Antonio Martinez-Sanchez, Navin Gopaldass, Ramona Choy, Andreas Mayer, Carsten Sachse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Autophagy-related protein 18 (Atg18) participates in the elongation of early autophagosomal structures in concert with Atg2 and Atg9 complexes. How Atg18 contributes to the structural coordination of Atg2 and Atg9 at the isolation membrane r
Externí odkaz:
https://doaj.org/article/9fabf27599ef4a30915746b4a6aefdb5
Publikováno v:
IUCrJ, Vol 10, Iss 4, Pp 475-486 (2023)
Structure determination of biological macromolecules using cryogenic electron microscopy is based on applying the phase object (PO) assumption and the weak phase object (WPO) approximation to reconstruct the 3D potential density of the molecule. To e
Externí odkaz:
https://doaj.org/article/04784ba678ca4bcc8fedf2516763f517
Autor:
Nora Lisa Bitzenhofer, Carolin Höfel, Stephan Thies, Andrea Jeanette Weiler, Christian Eberlein, Hermann J. Heipieper, Renu Batra‐Safferling, Pia Sundermeyer, Thomas Heidler, Carsten Sachse, Tobias Busche, Jörn Kalinowski, Thomke Belthle, Thomas Drepper, Karl‐Erich Jaeger, Anita Loeschcke
Publikováno v:
Microbial Biotechnology, Vol 17, Iss 1, Pp n/a-n/a (2024)
Abstract Pseudomonas species have become promising cell factories for the production of natural products due to their inherent robustness. Although these bacteria have naturally evolved strategies to cope with different kinds of stress, many biotechn
Externí odkaz:
https://doaj.org/article/bb479b74c3694adf923f65b0b3fa02f3
Autor:
Sabrina Berkamp, Deniz Daviran, Marit Smeets, Alexane Caignard, Riddhi Jani, Pia Sundermeyer, Caspar Jonker, Sven Gerlach, Bernd Hoffmann, Katherine Lau, Carsten Sachse
Publikováno v:
Bio-Protocol, Vol 13, Iss 24 (2023)
In situ cryo-electron tomography (cryo-ET) is the most current, state-of-the-art technique to study cell machinery in its hydrated near-native state. The method provides ultrastructural details at sub-nanometer resolution for many components within t
Externí odkaz:
https://doaj.org/article/9eeeeefcaa7e4f909695bec59e841964
Autor:
Konrad Sachse, Martin Hölzer, Fabien Vorimore, Lisa-Marie Barf, Carsten Sachse, Karine Laroucau, Manja Marz, Kevin Lamkiewicz
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-17 (2023)
Abstract Background Chlamydia (C.) psittaci, the causative agent of avian chlamydiosis and human psittacosis, is a genetically heterogeneous species. Its broad host range includes parrots and many other birds, but occasionally also humans (via zoonot
Externí odkaz:
https://doaj.org/article/e7ff89fd8bba4654ae6315ebc44b2fd0
Autor:
Lucas Gewehr, Benedikt Junglas, Ruven Jilly, Johannes Franz, Wenyu Eva Zhu, Tobias Weidner, Mischa Bonn, Carsten Sachse, Dirk Schneider
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Dynamin-like proteins are membrane remodeling GTPases with well-understood functions in eukaryotic cells. However, bacterial dynamin-like proteins are still poorly investigated. SynDLP, the dynamin-like protein of the cyanobacterium Synechoc
Externí odkaz:
https://doaj.org/article/6620f236a7994b4e9ceb79427a9499db
Autor:
Arjen J. Jakobi, Stefan T. Huber, Simon A. Mortensen, Sebastian W. Schultz, Anthimi Palara, Tanja Kuhm, Birendra Kumar Shrestha, Trond Lamark, Wim J. H. Hagen, Matthias Wilmanns, Terje Johansen, Andreas Brech, Carsten Sachse
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
PB1-mediated oligomerization of p62/SQSTM1 is essential for its function as a selective autophagy receptor. Here the authors present the cryo-EM structures of human and Arabidopsis PB1 domain helical assemblies and find that a conserved double argini
Externí odkaz:
https://doaj.org/article/3681d17d79a54c59a34880abff981baa