Výsledky vyhledávání - "Carsten Peukert"

Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens

Autor: Lukas Pinkert, Jörg Grunenberg, Mark Brönstrup, Bianka Karge, Yi-Hui Lai, Sven-Kevin Hotop, Lara Marie Schulze, Carsten Peukert

Publikováno v: Journal of Medicinal Chemistry. 64:15440-15460

The development of novel drugs against Gram-negative bacteria represents an urgent medical need. To overcome their outer cell membrane, we synthesized conjugates of antibiotics and artificial siderophores based on the MECAM core, which are imported b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b5070be2b5ebfdbe317c7846601b85
https://doi.org/10.1021/acs.jmedchem.1c01482

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Trojan Horse Siderophore Conjugates Induce

Autor: Carsten, Peukert, Véronique, Gasser, Till, Orth, Sarah, Fritsch, Vincent, Normant, Olivier, Cunrath, Isabelle J, Schalk, Mark, Brönstrup

Publikováno v: Journal of medicinal chemistry.

Rising infection rates with multidrug-resistant pathogens calls for antibiotics with novel modes of action. Herein, we identify the inner membrane protein TonB, a motor of active uptake in Gram-negative bacteria, as a novel target in antimicrobial th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6354af37340faf9ed0cfd332b9b2ab63
https://pubmed.ncbi.nlm.nih.gov/36548006

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Optimization of Artificial Siderophores as 68Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections

Autor: Jens P. Bankstahl, Anna Tutov, Tobias L. Ross, Frank M. Bengel, Carsten Peukert, Sophie M Wegener, Mark Brönstrup, Bianka Karge, Laura N B Langer

Publikováno v: Journal of Medicinal Chemistry. 64:12359-12378

The diagnosis of bacterial infections at deep body sites benefits from noninvasive imaging of molecular probes that can be traced by positron emission tomography (PET). We specifically labeled bacteria by targeting their iron transport system with ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c69ad95a2977a8fc6c67bd6d77e9a5a
https://doi.org/10.1021/acs.jmedchem.1c01054

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Trojan Horse siderophore conjugates induce P. aeruginosa suicide and qualify the TonB protein as a novel antibiotic target

Autor: Carsten Peukert, Veronique Gasser, Till Orth, Sarah Fritsch, Vincent Normant, Olivier Cunrath, Isabelle Schalk, Mark Brönstrup

Rising infection rates with multidrug-resistant bacterial pathogens such as Pseudomonas combined with a shallow antibiotic pipeline urgently call for antibiotics with novel modes of action. Herein, we identify the inner membrane protein TonB, motor o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00bd7431b606ce99c7c3685672d4ca66
https://doi.org/10.26434/chemrxiv-2022-9zvfx

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Uptake Mechanisms and Regulatory Responses to MECAM- and DOTAM-Based Artificial Siderophores and Their Antibiotic Conjugates in

Autor: Sarah, Fritsch, Véronique, Gasser, Carsten, Peukert, Lukas, Pinkert, Lauriane, Kuhn, Quentin, Perraud, Vincent, Normant, Mark, Brönstrup, Isabelle J, Schalk

Publikováno v: ACS infectious diseases. 8(6)

The development of new antibiotics against Gram-negative bacteria has to deal with the low permeability of the outer membrane. This obstacle can be overcome by utilizing siderophore-dependent iron uptake pathways as entrance routes for antibiotic upt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fd58c7e2f36e70d2b3666e3f68bf43f3
https://pubmed.ncbi.nlm.nih.gov/35500104

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Enzyme-Activated, Chemiluminescent Siderophore-Dioxetane Probes Enable the Selective and Highly Sensitive Detection of Bacterial Pathogens

Autor: Carsten Peukert, Sachin Popat Gholap, Ori Green, Lukas Pinkert, Joop van den Heuvel, Marco van Ham, Doron Shabat, Mark Brönstrup

Publikováno v: Angewandte Chemie (International ed. in English). 61(25)

The sensitive detection of bacterial infections is a prerequisite for their successful treatment. The use of a chemiluminescent readout was so far hampered by an insufficient probe enrichment at the pathogens. We coupled siderophore moieties, that ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56663f1b9a411f54e8818a5d154ea34
https://pubmed.ncbi.nlm.nih.gov/35358362

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