Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Carsten Merkwirth"'
Autor:
Richard A Furie, Van Anh Nguyen, Feng Hong, Scott R P McDonnell, Noah M Walton, Carsten Merkwirth, Deborah Berg, Elena Tomaselli Muensterman
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss 1 (2024)
Objective To evaluate safety and mechanism of action of mezagitamab (TAK-079), an anti-CD38 monoclonal antibody, in patients with moderate to severe systemic lupus erythematosus (SLE).Methods A phase 1b double-blind, placebo-controlled, multicentre s
Externí odkaz:
https://doaj.org/article/9545ba1275374259ad9a0a70853a795b
Autor:
Jennifer L. Green, Robin E. Osterhout, Amy L. Klova, Carsten Merkwirth, Scott R.P. McDonnell, Reza Beheshti Zavareh, Bryan C. Fuchs, Adeela Kamal, Jørn S. Jakobsen
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 547-559 (2021)
Although anti-tumor activities of type I interferons (IFNs) have been recognized for decades, the molecular mechanisms contributing to clinical response remain poorly understood. The complex functions of these pleiotropic cytokines include stimulatio
Externí odkaz:
https://doaj.org/article/3bdba8d9baec4171a65be46af11a81fb
Autor:
Christina Ising, Sybille Koehler, Sebastian Brähler, Carsten Merkwirth, Martin Höhne, Olivier R Baris, Henning Hagmann, Martin Kann, Francesca Fabretti, Claudia Dafinger, Wilhelm Bloch, Bernhard Schermer, Andreas Linkermann, Jens C Brüning, Christine E Kurschat, Roman‐Ulrich Müller, Rudolf J Wiesner, Thomas Langer, Thomas Benzing, Paul Thomas Brinkkoetter
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 3, Pp 275-287 (2015)
Abstract Mitochondrial dysfunction and alterations in energy metabolism have been implicated in a variety of human diseases. Mitochondrial fusion is essential for maintenance of mitochondrial function and requires the prohibitin ring complex subunit
Externí odkaz:
https://doaj.org/article/aaed36cafd0a43ab8e7e6120f044f0e0
Autor:
Carsten Merkwirth, Paola Martinelli, Anne Korwitz, Michela Morbin, Hella S Brönneke, Sabine D Jordan, Elena I Rugarli, Thomas Langer
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003021 (2012)
Fusion and fission of mitochondria maintain the functional integrity of mitochondria and protect against neurodegeneration, but how mitochondrial dysfunctions trigger neuronal loss remains ill-defined. Prohibitins form large ring complexes in the inn
Externí odkaz:
https://doaj.org/article/5db45e9d209245a78fd19f8f0e725ed6
Autor:
Bryan C. Fuchs, Jennifer Green, Robin Osterhout, Scott Rp McDonnell, Amy Klova, Jørn S. Jakobsen, Adeela Kamal, Carsten Merkwirth, Reza Beheshti Zavareh
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 23, Iss, Pp 547-559 (2021)
Molecular Therapy: Oncolytics, Vol 23, Iss, Pp 547-559 (2021)
Although anti-tumor activities of type I interferons (IFNs) have been recognized for decades, the molecular mechanisms contributing to clinical response remain poorly understood. The complex functions of these pleiotropic cytokines include stimulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf55136ff7d65648a4063772b3ad294
https://doi.org/10.1016/j.omto.2021.11.006
https://doi.org/10.1016/j.omto.2021.11.006
Autor:
Elizabeth A. McMillan, Carine Bossard, Emily Creger, Carsten Merkwirth, Raffaella Pippa, Matthew Jarvis, Krishna Sriram, Melinda Pedraza, Maureen Ibanez, Deepti Bhat, Carolyn Lai, Josh Stewart, Brian Eastman, Chi-Ching Mak, Michael A. White, Darrin Beaupre
Publikováno v:
Cancer Research. 82:3928-3928
Dysregulated alternative pre-mRNA splicing (AS) is commonly associated with human malignancies, producing pathological proteomes that underlie disease initiation, progression, and therapeutic resistance. The CDC2-like kinases (CLKs) and dual-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e46f4bcd59e8ede8c3333479cae32f5
https://doi.org/10.1158/1538-7445.am2022-3928
https://doi.org/10.1158/1538-7445.am2022-3928
Autor:
Elizabeth A. McMillan, Krishna Sriram, Emily Creger, Carsten Merkwirth, Raffaella Pippa, Melinda Pedraza, Long Do, Vishal Deshmukh, Carine Bossard, Michael A. White
Publikováno v:
Molecular Cancer Therapeutics. 20:P231-P231
Alternative pre-mRNA splicing (AS) supports the dynamic and regulated diversification of cells by allowing the production of multiple distinct proteins from individual genes. Dysregulated AS is commonly associated with human malignancies, producing p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09c027a791a117033804ef5f5b4f56b3
https://doi.org/10.1158/1535-7163.targ-21-p231
https://doi.org/10.1158/1535-7163.targ-21-p231
Autor:
Carine Bossard, Emily Creger, Elizabeth A. McMillan, Carsten Merkwirth, Maureen Ibanez, Deepti Bhat, Josh Stewart, Brian Eastman, Chi-Ching Mak, Vishal Deshmukh, Michael A. White
Publikováno v:
Molecular Cancer Therapeutics. 20:P242-P242
A monumental challenge facing cancer therapy is the vast mechanistic diversity of tumors among and even within cancer patients. This severely limits the number of patients that respond to any given therapy and the durability of responses that do occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f94f5e145f18607c0a4b5a493360edc1
https://doi.org/10.1158/1535-7163.targ-21-p242
https://doi.org/10.1158/1535-7163.targ-21-p242
Autor:
Carsten Merkwirth, Roman U. Müller, Christine Kurschat, Martin Höhne, Christina Ising, Bernhard Schermer, Dontscho Kerjaschki, Francesca Fabretti, Henning Hagmann, Sebastian Brähler, Sibylle Brinkkoetter, Wilhelm Bloch, Christina B. Schroeter, Sybille Koehler, Puneet Bharill, Thomas Benzing, Paul T. Brinkkoetter
Publikováno v:
The American Journal of Pathology. 186:1128-1139
Mitochondrial fusion is essential for maintenance of mitochondrial function and requires the prohibitin ring complex subunit prohibitin-2 (PHB2) at the mitochondrial inner membrane. Loss of the stomatin/PHB/flotillin/HflK/C (SPFH) domain containing p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46819cfc4ae44488c45a83b19602a3d
https://doi.org/10.1016/j.ajpath.2015.12.018
https://doi.org/10.1016/j.ajpath.2015.12.018
Autor:
Carsten Merkwirth, Jenni Durieux, Kristan K. Steffen, Sarah U. Tronnes, Johan Auwerx, Olli Matilainen, Evan G. Williams, Laurent Mouchiroud, Sabine D. Jordan, Suzanne Wolff, Virginia Murillo, Reuben J. Shaw, Andrew Dillin, Pedro M. Quirós, Virginija Jovaisaite
Publikováno v:
Cell, vol 165, iss 5
Across eukaryotic species, mild mitochondrial stress can have beneficial effects on the lifespan of organisms. Mitochondrial dysfunction activates an unfolded protein response (UPR(mt)), a stress signaling mechanism designed to ensure mitochondrial h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c26dd40985123aa7a24bf87ba43e34
https://doi.org/10.1016/j.cell.2016.04.012
https://doi.org/10.1016/j.cell.2016.04.012