Zobrazeno 1 - 10
of 303
pro vyhledávání: '"Carsten Marr"'
Autor:
Sayedali Shetab Boushehri, Katharina Essig, Nikolaos-Kosmas Chlis, Sylvia Herter, Marina Bacac, Fabian J. Theis, Elke Glasmacher, Carsten Marr, Fabian Schmich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Therapeutic antibodies are widely used to treat severe diseases. Most of them alter immune cells and act within the immunological synapse; an essential cell-to-cell interaction to direct the humoral immune response. Although many antibody de
Externí odkaz:
https://doaj.org/article/62bbe8bd93374bf38cb0af38e85b4d6d
Autor:
Shruthi Kalgudde Gopal, Ruoxuan Dai, Ania Maria Stefanska, Meshal Ansari, Jiakuan Zhao, Pushkar Ramesh, Johannes W. Bagnoli, Donovan Correa-Gallegos, Yue Lin, Simon Christ, Ilias Angelidis, Valerio Lupperger, Carsten Marr, Lindsay C. Davies, Wolfgang Enard, Hans-Günther Machens, Herbert B. Schiller, Dongsheng Jiang, Yuval Rinkevich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The origins of wound myofibroblasts and scar tissue remains unclear, but it is assumed to involve conversion of adipocytes into myofibroblasts. Here, we directly explore the potential plasticity of adipocytes and fibroblasts after skin injur
Externí odkaz:
https://doaj.org/article/555bd59cdc42402d93754aed435aa3b6
Autor:
Dantong Wang, Christian Rausch, Simon A. Buerger, Sebastian Tschuri, Maja Rothenberg-Thurley, Melanie Schulz, Jan Hasenauer, Frank Ziemann, Klaus H. Metzeler, Carsten Marr
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108271- (2023)
Summary: Monitoring disease response after intensive chemotherapy for acute myeloid leukemia (AML) currently requires invasive bone marrow biopsies, imposing a significant burden on patients. In contrast, cell-free tumor DNA (ctDNA) in peripheral blo
Externí odkaz:
https://doaj.org/article/a87bd4672a504f84ab977b2015222c06
Autor:
Michèle C. Buck, Lisa Bast, Judith S. Hecker, Jennifer Rivière, Maja Rothenberg-Thurley, Luisa Vogel, Dantong Wang, Immanuel Andrä, Fabian J. Theis, Florian Bassermann, Klaus H. Metzeler, Robert A.J. Oostendorp, Carsten Marr, Katharina S. Götze
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107328- (2023)
Summary: Clonal hematopoiesis of indeterminate potential (CHIP) describes the age-related acquisition of somatic mutations in hematopoietic stem/progenitor cells (HSPC) leading to clonal blood cell expansion. Although CHIP mutations drive myeloid mal
Externí odkaz:
https://doaj.org/article/a281b751b3e543528abcca4b0e8c1c42
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Hematologists analyze microscopic images of red blood cells to study their morphology and functionality, detect disorders and search for drugs. However, accurate analysis of a large number of red blood cells needs automated computationa
Externí odkaz:
https://doaj.org/article/20f0f5c0a9c04e45beec0c7b8cb9e6fc
Autor:
Christian Klein, Daria Briukhovetska, Michael von Bergwelt-Baildon, Sebastian Kobold, Mitchell P Levesque, Bruno L Cadilha, Stefan Endres, Mohamed-Reda Benmebarek, Hannah Obeck, Sophia Stock, Florian Märkl, Julius Keyl, Martina Geiger, Clara Karches, Melanie Schwerdtfeger, Stefanos Michaelides, Jakob Jobst, Philipp Jie Müller, Lina Majed, Matthias Seifert, Anna-Kristina Klüver, Theo Lorenzini, Ruth Grünmeier, Moritz Thomas, Adrian Gottschlich, Richard Klaus, Carsten Marr, Simon Rothenfusser, Markus Vincent Heppt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Melanoma is an immune sensitive disease, as demonstrated by the activity of immune check point blockade (ICB), but many patients will either not respond or relapse. More recently, tumor infiltrating lymphocyte (TIL) therapy has shown promi
Externí odkaz:
https://doaj.org/article/b199e93aa3494d549053b8485d6551d1
Autor:
Matthias Hehr, Ario Sadafi, Christian Matek, Peter Lienemann, Christian Pohlkamp, Torsten Haferlach, Karsten Spiekermann, Carsten Marr
Publikováno v:
PLOS Digital Health, Vol 2, Iss 3, p e0000187 (2023)
Explainable AI is deemed essential for clinical applications as it allows rationalizing model predictions, helping to build trust between clinicians and automated decision support tools. We developed an inherently explainable AI model for the classif
Externí odkaz:
https://doaj.org/article/010031bc6f9549dd948d6f0be25758d1
Autor:
Ziqi Yu, Xiaoyang Han, Wenjing Xu, Jie Zhang, Carsten Marr, Dinggang Shen, Tingying Peng, Xiao-Yong Zhang, Jianfeng Feng
Publikováno v:
eLife, Vol 11 (2022)
Accurate brain tissue extraction on magnetic resonance imaging (MRI) data is crucial for analyzing brain structure and function. While several conventional tools have been optimized to handle human brain data, there have been no generalizable methods
Externí odkaz:
https://doaj.org/article/88b5ab1959e34957a3768d7f100227be
Autor:
Dominik J.E. Waibel, Niklas Kiermeyer, Scott Atwell, Ario Sadafi, Matthias Meier, Carsten Marr
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105298- (2022)
Summary: Reconstruction of shapes and sizes of three-dimensional (3D) objects from two- dimensional (2D) information is an intensely studied subject in computer vision. We here consider the level of single cells and nuclei and present a neural networ
Externí odkaz:
https://doaj.org/article/66da5079998d4482969bac602c7c9e0f
Autor:
Lea Schuh, Igor Kukhtevich, Poonam Bheda, Melanie Schulz, Maria Bordukova, Robert Schneider, Carsten Marr
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010640 (2022)
Cells must continuously adjust to changing environments and, thus, have evolved mechanisms allowing them to respond to repeated stimuli. While faster gene induction upon a repeated stimulus is known as reinduction memory, responses to repeated repres
Externí odkaz:
https://doaj.org/article/c5e0bf1cc0da4065bf74c156ed76dd54