Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Carsten Kuenne"'
Autor:
Marga Albu, Eileen Affolter, Alessandra Gentile, Yanli Xu, Khrievono Kikhi, Sarah Howard, Carsten Kuenne, Rashmi Priya, Felix Gunawan, Didier Y. R. Stainier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Tissues undergo distinct morphogenetic processes to achieve similarly shaped structures. In the heart, cardiomyocytes in both the ventricle and atrium build internal structures for efficient contraction. Ventricular wall formation (trabecula
Externí odkaz:
https://doaj.org/article/a55a62305a4c491d8c45ee1f4c8ef7c5
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 3, Pp 568-577 (2022)
Data visualization and interactive data exploration are important aspects of illustrating complex concepts and results from analyses of omics data. A suitable visualization has to be intuitive and accessible. Web-based dashboards have become popular
Externí odkaz:
https://doaj.org/article/c82206558a77411d965f945ffe0d19b8
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4040-4051 (2022)
Cooperativity between transcription factors is important to regulate target gene expression. In particular, the binding grammar of TFs in relation to each other, as well as in the context of other genomic elements, is crucial for TF functionality. Ho
Externí odkaz:
https://doaj.org/article/0523656b6ae444aaa31659dacdc96f0c
Autor:
Mette Bentsen, Philipp Goymann, Hendrik Schultheis, Kathrin Klee, Anastasiia Petrova, René Wiegandt, Annika Fust, Jens Preussner, Carsten Kuenne, Thomas Braun, Johnny Kim, Mario Looso
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Footprinting analysis allows genome-wide investigation of transcription factor (TF) binding on chromatin. Here the authors developed a framework termed TOBIAS aimed at identifying footprints of chromatin-associated proteins from ATAC-seq accessibilit
Externí odkaz:
https://doaj.org/article/e3286bfee3c34ca8982de7e68a99c0a2
Autor:
Guangshuai Jia, Jens Preussner, Xi Chen, Stefan Guenther, Xuejun Yuan, Michail Yekelchyk, Carsten Kuenne, Mario Looso, Yonggang Zhou, Sarah Teichmann, Thomas Braun
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Cardiac progenitor cells (CPCs) form cardiomyocytes, pericytes, smooth muscle and endothelial cells during embryonic development. Here, the authors characterize mouse CPCs marked by Nkx2.5 and Isl1 from E7.5 to E9.5 by single cell RNA-seq and ATAC-se
Externí odkaz:
https://doaj.org/article/f7864042a18d4c6f9b5af4ce0b06ab0a
Autor:
Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, Stefan Günther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente, Didier Y. R. Stainier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The glycolytic enzyme pyruvate kinase M2 (PKM2) is required for nucleotide synthesis and cell proliferation. Using gene expression and metabolomics analyses, the authors here show that PKM2 regulates methionine metabolism and DNA methylation in endot
Externí odkaz:
https://doaj.org/article/193983107e6a406b9727e989c6776bf0
Autor:
Flávia Rezende, Franziska Moll, Maria Walter, Valeska Helfinger, Fabian Hahner, Patrick Janetzko, Christian Ringel, Andreas Weigert, Ingrid Fleming, Norbert Weissmann, Carsten Kuenne, Mario Looso, Michael A. Rieger, Peter Nawroth, Thomas Fleming, Ralf P. Brandes, Katrin Schröder
Publikováno v:
Redox Biology, Vol 15, Iss C, Pp 12-21 (2018)
Aim: NADPH oxidases are important sources of reactive oxygen species (ROS). Several Nox homologues are present together in the vascular system but whether they exhibit crosstalk at the activity level is unknown. To address this, vessel function of kn
Externí odkaz:
https://doaj.org/article/14fec7c9b3eb4530bf8d0d3807311da9
Autor:
Chiara Cencioni, Francesco Spallotta, Matteo Savoia, Carsten Kuenne, Stefan Guenther, Agnese Re, Susanne Wingert, Maike Rehage, Duran Sürün, Mauro Siragusa, Jacob G. Smith, Frank Schnütgen, Harald von Melchner, Michael A. Rieger, Fabio Martelli, Antonella Riccio, Ingrid Fleming, Thomas Braun, Andreas M. Zeiher, Antonella Farsetti, Carlo Gaetano
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The production of nitric oxide (NO) is required for early stage embryo implantation into the uterus. Here the authors show that during differentiation of naive mouse ESCs, early production of endogenous NO leads to a mesendoderm differentiation commi
Externí odkaz:
https://doaj.org/article/a14bcea599a241e4b7bb31b5f8b2ac2b
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The annotation of genomic ranges of interest represents a recurring task for bioinformatics analyses. These ranges can originate from various sources, including peaks called for transcription factor binding sites (TFBS) or histone modificati
Externí odkaz:
https://doaj.org/article/07c5dac7268642de8a4a45160f168774
Correction: Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish.
Autor:
Anna M Sokol, Barbara Uszczynska-Ratajczak, Michelle M Collins, Michal Bazala, Ulrike Topf, Pia R Lundegaard, Sreedevi Sugunan, Stefan Guenther, Carsten Kuenne, Johannes Graumann, Sherine S L Chan, Didier Y R Stainier, Agnieszka Chacinska
Publikováno v:
PLoS Genetics, Vol 15, Iss 1, p e1007972 (2019)
[This corrects the article DOI: 10.1371/journal.pgen.1007743.].
Externí odkaz:
https://doaj.org/article/7b73b7d754a74cebb5b5c4b59e3956f3