Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Carsten Jagusch"'
Publikováno v:
Tetrahedron. 68:697-704
α-Aminoesters react with Ph3PCCO in a domino addition–Wittig cyclization sequence affording enantiomerically pure tetramates. In the case of β-oxo functionalized α-aminoesters, e.g., esters of serine, threonine or β-hydroxyornithine the yields
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a98406bf1c5f50f89828e77e22cb410e
https://doi.org/10.1016/j.tet.2011.10.099
https://doi.org/10.1016/j.tet.2011.10.099
Publikováno v:
Journal of Medicinal Chemistry. 53:5749-5758
Androgens are well-known to stimulate prostate cancer (PC) growth. Thus, blockade of androgen production in testes and adrenals by CYP17 inhibition is a promising strategy for the treatment of PC. Moreover, many PC patients suffer from glucocorticoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278234fd9e8b55c5b35badd2a6734b44
https://doi.org/10.1021/jm100317b
https://doi.org/10.1021/jm100317b
Autor:
Dirk Schmidt, Rolf W. Hartmann, Matthias Negri, Carsten Jagusch, Mariano A E Pinto-Bazurco Mendieta, Ulrike E. Hille, Klaus Hansen, Ursula Müller-Vieira
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:267-273
Two novel classes of non-steroidal substrate mimetics were synthesised and examined for their potency as inhibitors of human CYP17. Selected compounds were tested for inhibition of hepatic CYP enzymes 3A4, 1A2, 2C9 and 2C19. The most promising compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a345a1c49b5386f0daf8282828dd7b
https://doi.org/10.1016/j.bmcl.2007.10.079
https://doi.org/10.1016/j.bmcl.2007.10.079
Autor:
Rainer Schobert, Carsten Jagusch
Publikováno v:
Tetrahedron. 61:2301-2307
The naturally occurring 3-acyltetramic acids (3-acylpyrrolidine-2,4-diones) melophlin A, B, C and G were prepared in few steps from α-aminoesters or their hydrochlorides by cyclization with Ph3PCCO under mild conditions. The employment of immobilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8b5d182755a91e1dfe125ee63eb495f
https://doi.org/10.1016/j.tet.2005.01.036
https://doi.org/10.1016/j.tet.2005.01.036
Autor:
Carsten Jagusch, Rainer Schobert
Publikováno v:
Tetrahedron Letters. 44:6449-6451
Domino addition–Wittig olefination reactions of α-hydroxy esters immobilized on polystyrene with Ph 3 PCCO to give resin-bound tetronates proceed as readily as in solution. α-Hydroxy allyl esters can react to give either supported allyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6daa3668d840e64e9ab48b08ed483e73
https://doi.org/10.1016/s0040-4039(03)01582-x
https://doi.org/10.1016/s0040-4039(03)01582-x
Publikováno v:
ChemInform. 43
The domino addition—Wittig cyclization sequence produces enantiomerically pure tetramate structures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78b2bf07c9b1fb3d423196b4901857bc
https://doi.org/10.1002/chin.201226105
https://doi.org/10.1002/chin.201226105
Publikováno v:
Journal of medicinal chemistry. 53(13)
CYP17 inhibition is a promising therapy for prostate cancer (PC) because proliferation of 80% of PC depends on androgen stimulation. Introduction of isopropylidene substituents onto the linker of biphenylmethylene 4-pyridines resulted in several stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ecdbabab331ca52d35d32db9fb10b0
https://pubmed.ncbi.nlm.nih.gov/20550118
https://pubmed.ncbi.nlm.nih.gov/20550118
Autor:
Georg Rapp, Florenz Sasse, Bernhard Biersack, Randi Diestel, Carsten Jagusch, Rainer Schobert
Publikováno v:
ChemInform. 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b0613e64271601852c2354b044b8a76
https://doi.org/10.1002/chin.200912210
https://doi.org/10.1002/chin.200912210
Autor:
Mariano A E Pinto-Bazurco Mendieta, Ursula Mueller‐Vieira, Ulrike E. Hille, Thomas Lauterbach, Carsten Jagusch, Matthias Negri, Dirk Schmidt, Rolf W. Hartmann, Kerstin Jahn-Hoffmann, Qingzhong Hu
Publikováno v:
ChemInform. 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d5c6f13899ecdf1cc5edaa3698efa40
https://doi.org/10.1002/chin.200906139
https://doi.org/10.1002/chin.200906139
Autor:
Randi Diestel, Georg Rapp, Rainer Schobert, Bernhard Biersack, Florenz Sasse, Carsten Jagusch
The marine tetramic acid (=1,5-dihydro-4-hydroxy-2H-pyrrol-2-ones) derivatives melophlin P, Q, and R (1p-1r, resp.) were synthesized for the first time in only four steps. Together with the congenerous melophlins A-C and G, they were also tested for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8749760f5c3a33a44d77400b722e0420
https://hdl.handle.net/10033/620815
https://hdl.handle.net/10033/620815
