Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Carsten Jacobi"'
Autor:
Kristine Pettersen, Sonja Andersen, Anna van derVeen, Unni Nonstad, Shinji Hatakeyama, Christian Lambert, Estelle Lach‐Trifilieff, Siver Moestue, Jana Kim, Bjørn Henning Grønberg, Alain Schilb, Carsten Jacobi, Geir Bjørkøy
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 1, Pp 195-207 (2020)
Abstract Background The majority of patients with advanced cancer develop cachexia, a weight loss syndrome that severely reduces quality of life and limits survival. Our understanding of the underlying mechanisms that cause the condition is limited,
Externí odkaz:
https://doaj.org/article/2b34fc30e6b1483b8ed40de97b7b7be2
Autor:
Joanna Brzeszczyńska, Angelika Meyer, Robin McGregor, Alain Schilb, Simone Degen, Valentina Tadini, Neil Johns, Ramon Langen, Annemie Schols, David J. Glass, Ronenn Roubenoff, James A. Ross, Kenneth C.H. Fearon, Carolyn A. Greig, Carsten Jacobi
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 1, Pp 93-105 (2018)
Abstract Background Sarcopenia is defined as the age‐related loss of skeletal muscle mass and function. While all humans lose muscle with age, 2–5% of elderly adults develop functional consequences (disabilities). The aim of this study was to inv
Externí odkaz:
https://doaj.org/article/c09f7a587c5642489648c9ba03775860
Autor:
Kristine Pettersen, Sonja Andersen, Simone Degen, Valentina Tadini, Joël Grosjean, Shinji Hatakeyama, Almaz N. Tesfahun, Siver Moestue, Jana Kim, Unni Nonstad, Pål R. Romundstad, Frank Skorpen, Sveinung Sørhaug, Tore Amundsen, Bjørn H. Grønberg, Florian Strasser, Nathan Stephens, Dag Hoem, Anders Molven, Stein Kaasa, Kenneth Fearon, Carsten Jacobi, Geir Bjørkøy
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional status and survival.
Externí odkaz:
https://doaj.org/article/8e2fd60ce44a48aa9b84c81781b5c0b3
Autor:
Oddrun Elise Olsen, Hanne Hella, Samah Elsaadi, Carsten Jacobi, Erik Martinez-Hackert, Toril Holien
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 519 (2020)
Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway. In some cases, activins also signal via the bone morphogenetic protein (
Externí odkaz:
https://doaj.org/article/a3570249fef646c285bb3569bc02283d
Autor:
Adam Papadimitropoulos, Elia Piccinini, Sophie Brachat, Alessandra Braccini, David Wendt, Andrea Barbero, Carsten Jacobi, Ivan Martin
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102359 (2014)
Mesenchymal stromal/stem cell (MSC) expansion in conventional monolayer culture on plastic dishes (2D) leads to progressive loss of functionality and thus challenges fundamental studies on the physiology of skeletal progenitors, as well as translatio
Externí odkaz:
https://doaj.org/article/d356053bb96e4562bcee6e426f4b273d
Autor:
Neil Johns, Shinji Hatakeyama, Nathan A Stephens, Martin Degen, Simone Degen, Wilfried Frieauff, Christian Lambert, James A Ross, Ronenn Roubenoff, David J Glass, Carsten Jacobi, Kenneth C H Fearon
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83618 (2014)
BACKGROUND: Cachexia affects the majority of patients with advanced cancer and is associated with a reduction in treatment tolerance, response to therapy, and duration of survival. One impediment towards the effective treatment of cachexia is a valid
Externí odkaz:
https://doaj.org/article/137790f226e44fdeb5933e061427f34e
Autor:
Nicole Gerwin, Celeste Scotti, Christine Halleux, Mara Fornaro, Jimmy Elliott, Yunyu Zhang, Kristen Johnson, Jian Shi, Sandra Walter, Yufei Li, Carsten Jacobi, Nelly Laplanche, Magali Belaud, Jochen Paul, Gustavo Glowacki, Thomas Peters, Keith A. Wharton, Igor Vostiar, Florine Polus, Ina Kramer, Sabine Guth, Abdelkader Seroutou, Subhajit Choudhury, Didier Laurent, Joseph Gimbel, Jörg Goldhahn, Matthias Schieker, Sophie Brachat, Ronenn Roubenoff, Michaela Kneissel
Publikováno v:
Nature medicine. 28(12)
Osteoarthritis (OA) is a common, debilitating, chronic disease with no disease-modifying drug approved to date. We discovered LNA043—a derivative of angiopoietin-like 3 (ANGPTL3)—as a potent chondrogenesis inducer using a phenotypic screen with h
Autor:
Joanna Brzeszczynska, Neil Johns, Simone Degen, Alain Schilb, Ronenn Roubenoff, Carsten Jacobi, Kenneth C. H. Fearon, Angelika Meyer, Carolyn A. Greig, James A. Ross, Robin A. McGregor, David J. Glass, Ramon C. J. Langen, Annemie M. W. J. Schols, Valentina Tadini
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle. 9:93-105
BACKGROUND Sarcopenia is defined as the age-related loss of skeletal muscle mass and function. While all humans lose muscle with age, 2-5% of elderly adults develop functional consequences (disabilities). The aim of this study was to investigate musc
Autor:
Estelle Lach-Trifilieff, Elke Koch, Claudia Koelbing, Frederic Morvan, Carsten Jacobi, Chao Zou, Xavier Charles Leber, Gauthier Toussaint, Meike Scharenberg, Alain Schilb, David J. Glass, Clemens Scheufler, Pascale Brebbia, Giulia Minetti, Sabine Geisse, Florian Witte, Veronique Ritter, S. Lehmann, Jean-Michel Rondeau
Publikováno v:
Proceedings of the National Academy of Sciences. 114:12448-12453
The TGF-β family ligands myostatin, GDF11, and activins are negative regulators of skeletal muscle mass, which have been reported to primarily signal via the ActRIIB receptor on skeletal muscle and thereby induce muscle wasting described as cachexia
Autor:
Carolyn A. Greig, H. Alexander Ebhardt, Valentina Tadini, Ruedi Aebersold, Simone Degen, Carsten Jacobi, Alain Schilb, Kenneth C. H. Fearon, Neil Johns
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle. 8:567-582
Background Cancer cachexia (cancer-induced muscle wasting) is found in a subgroup of cancer patients leaving the patients with a poor prognosis for survival due to a lower tolerance of the chemotherapeutic drug. The cause of the muscle wasting in the