Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Carsten Höltke"'
Autor:
Emily Hoffmann, Daniel Schache, Carsten Höltke, Jens Soltwisch, Stephan Niland, Tobias Krähling, Klaus Bergander, Martin Grewer, Christiane Geyer, Linda Groeneweg, Johannes A. Eble, Thomas Vogl, Johannes Roth, Walter Heindel, Bastian Maus, Anne Helfen, Cornelius Faber, Moritz Wildgruber, Mirjam Gerwing, Verena Hoerr
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background With metabolic alterations of the tumor microenvironment (TME) contributing to cancer progression, metastatic spread and response to targeted therapies, non-invasive and repetitive imaging of tumor metabolism is of major importanc
Externí odkaz:
https://doaj.org/article/76432bd0b33048e585ea50f788f241f8
Autor:
Emily Hoffmann, Mirjam Gerwing, Tobias Krähling, Uwe Hansen, Katharina Kronenberg, Max Masthoff, Christiane Geyer, Carsten Höltke, Lydia Wachsmuth, Regina Schinner, Verena Hoerr, Walter Heindel, Uwe Karst, Michel Eisenblätter, Bastian Maus, Anne Helfen, Cornelius Faber, Moritz Wildgruber
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-16 (2023)
Abstract Background Response assessment of targeted cancer therapies is becoming increasingly challenging, as it is not adequately assessable with conventional morphological and volumetric analyses of tumor lesions. The tumor microenvironment is part
Externí odkaz:
https://doaj.org/article/bb457be90422403fb4b3cade4f355994
Autor:
Thomas Vogl, Moritz Wildgruber, Cornelius Faber, Emily Hoffmann, Mirjam Gerwing, Stephan Niland, Rolf Niehoff, Max Masthoff, Christiane Geyer, Lydia Wachsmuth, Enrica Wilken, Carsten Höltke, Walter L Heindel, Verena Hoerr, Regina Schinner, Philipp Berger, Johannes A Eble, Bastian Maus, Anne Helfen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background The inflammatory tumor microenvironment (TME) is formed by various immune cells, being closely associated with tumorigenesis. Especially, the interaction between tumor-infiltrating T-cells and macrophages has a crucial impact on tumor prog
Externí odkaz:
https://doaj.org/article/e0037d62af4746e08616a8d85ec2720a
Autor:
Mirjam Gerwing, Emily Hoffmann, Katharina Kronenberg, Uwe Hansen, Max Masthoff, Anne Helfen, Christiane Geyer, Lydia Wachsmuth, Carsten Höltke, Bastian Maus, Verena Hoerr, Tobias Krähling, Lena Hiddeßen, Walter Heindel, Uwe Karst, Melanie A. Kimm, Regina Schinner, Michel Eisenblätter, Cornelius Faber, Moritz Wildgruber
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ObjectiveThe objective of this study was to non-invasively differentiate the degree of malignancy in two murine breast cancer models based on identification of distinct tissue characteristics in a metastatic and non-metastatic tumor model using a mul
Externí odkaz:
https://doaj.org/article/107f5fb2d2b74102a992a5af89cfb498
Autor:
Anne Helfen, Jan Rieß, Olesja Fehler, Miriam Stölting, Zhengwen An, Vanessa Kocman, Annika Schnepel, Christiane Geyer, Mirjam Gerwing, Max Masthoff, Thomas Vogl, Carsten Höltke, Johannes Roth, Tony Ng, Moritz Wildgruber, Michel Eisenblätter
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 28, Iss , Pp 100792- (2022)
Purpose: As a promotor of tumor invasion and tumor microenvironment (TME) formation, the protein complex S100A8/S100A9 is associated with poor prognosis. Our aim was to further evaluate its origin and regulatory effects, and to establish an imaging b
Externí odkaz:
https://doaj.org/article/17a0fa249da946bb93be8cdd38a154f0
Autor:
Carsten Höltke, Wael Alsibai, Martin Grewer, Miriam Stölting, Christiane Geyer, Michel Eisenblätter, Moritz Wildgruber, Anne Helfen
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The biodistribution of medical imaging probes depends on the chemical nature of the probe and the preferred metabolization and excretion routes. Especially targeted probes, which have to reach a certain (sub)cellular destination, have to be guided to
Externí odkaz:
https://doaj.org/article/0d82ee3cd61a4761a1ffc029a353f2ef
Autor:
Melanie A Kimm, Claudia Gross, Xose Luis Déan-Ben, Avihai Ron, Ernst J Rummeny, Hsiao-Chun Amy Lin, Carsten Höltke, Daniel Razansky, Moritz Wildgruber
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217576 (2019)
Doxorubicin (DOX) is a widely used chemotherapeutic anticancer drug. Its intrinsic fluorescence properties enable investigation of tumor response, drug distribution and metabolism. First phantom studies in vitro showed optoacoustic property of DOX. W
Externí odkaz:
https://doaj.org/article/cdba2e6fbdd748efb7da27963f3f9767
Autor:
Anne Helfen, Annika Schnepel, Jan Rieß, Miriam Stölting, Mirjam Gerwing, Max Masthoff, Thomas Vogl, Johannes Roth, Carsten Höltke, Moritz Wildgruber, Michel Eisenblätter
Publikováno v:
Biomedicines, Vol 9, Iss 1, p 29 (2021)
(1) Background: The prognosis of cancer is dependent on immune cells in the tumor microenvironment (TME). The protein S100A9 is an essential regulator of the TME, associated with poor prognosis. In this study, we evaluated early therapy effects on th
Externí odkaz:
https://doaj.org/article/2f86bba14f9c4fa089b2d2027e5c029c
Autor:
Miriam Stölting, Christiane Geyer, Anne Helfen, Anke Hahnenkamp, Marco V. Usai, Eva Wardelmann, Michael T. Kuhlmann, Moritz Wildgruber, Carsten Höltke
Publikováno v:
Biomedicines, Vol 8, Iss 12, p 538 (2020)
Cardiovascular disease remains the most frequent cause of death worldwide. Atherosclerosis, an underlying cause of cardiovascular disease, is an inflammatory disorder associated with endothelial dysfunction. The endothelin system plays a crucial role
Externí odkaz:
https://doaj.org/article/6e88b731bccb451da072d36fb6d1f9f4
Autor:
Fabian Lohöfer, Laura Hoffmann, Rebecca Buchholz, Katharina Huber, Almut Glinzer, Katja Kosanke, Annette Feuchtinger, Michaela Aichler, Benedikt Feuerecker, Georgios Kaissis, Ernst J. Rummeny, Carsten Höltke, Cornelius Faber, Franz Schilling, René M. Botnar, Axel K. Walch, Uwe Karst, Moritz Wildgruber
Publikováno v:
Heliyon, Vol 4, Iss 4, Pp e00606- (2018)
Background: Molecular MRI is becoming increasingly important for preclinical research. Validation of targeted gadolinium probes in tissue however has been cumbersome up to now. Novel methodology to assess gadolinium distribution in tissue after in vi
Externí odkaz:
https://doaj.org/article/c9ad0ab9a9cc434bbf3e3dcd2f49776a