Serine Phosphorylation of L-Selectin Regulates ERM Binding, Clustering, and Monocyte Protrusion in Transendothelial Migration

Autor: Abigail Newe, Karolina Rzeniewicz, Melanie König, Carsten F. E. Schroer, Justin Joachim, Angela Rey-Gallardo, Siewert J. Marrink, Jürgen Deka, Maddy Parsons, Aleksandar Ivetic

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

The migration of circulating leukocytes toward damaged tissue is absolutely fundamental to the inflammatory response, and transendothelial migration (TEM) describes the first cellular barrier that is breached in this process. Human CD14+ inflammatory

Externí odkaz: https://doaj.org/article/eccfc0ffef7e4d0e8d2c08cc4808aab8

Charge-dependent interactions of monomeric and filamentous actin with lipid bilayers

Autor: Lennard van Buren, Siewert J. Marrink, Tsjerk A. Wassenaar, Lucia Baldauf, Manuel N. Melo, Gijsje H. Koenderink, Carsten F. E. Schroer

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 117(11)
Proceedings of the National Academy of Sciences of the United States of America, 117(11):pnas.1914884117, 5861-5872. NATL ACAD SCIENCES

Significance Actin filaments are biopolymers that reside close to the plasma membrane in mammalian cells and are essential for its mechanical stability and shape. In vitro experiments have demonstrated that direct interactions between actin strands a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abaf8b5fb6a04565d801ce63111540c
https://hdl.handle.net/11370/4bc3592d-6fdc-4a80-bec6-6bd016e9b3f9

Nonlinear response from the perspective of energy landscapes and beyond

Autor: Christian Rehwald, Diddo Diddens, Markus Blank-Burian, Carsten F. E. Schroer, Andreas Heuer

Publikováno v: The European Physical Journal Special Topics. 226:3061-3078

The paper discusses the nonlinear response of disordered systems. In particular we show how the nonlinear response can be interpreted in terms of properties of the potential energy landscape. It is shown why the use of relatively small systems is ver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4a7935b64460d0bc4a6fefdf65b115c
https://doi.org/10.1140/epjst/e2017-70080-x

Molecular mechanism for bidirectional regulation of CD44 for lipid raft affiliation by palmitoylations and PIP2

Autor: Lida Xu, Carlos R Palacios, Siewert J. Marrink, Carsten F. E. Schroer, Shi-Zhong Luo, Fude Sun

Publikováno v: PLoS Computational Biology, Vol 16, Iss 4, p e1007777 (2020)
PLoS Computational Biology, 16(4):e1007777. PUBLIC LIBRARY SCIENCE
PLoS Computational Biology

The co-localization of Cluster-of-Differentiation-44 protein (CD44) and cytoplasmic adaptors in specific membrane environments is crucial for cell adhesion and migration. The process is controlled by two different pathways: On the one hand palmitoyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03686d8ceeca56f66a673dfbd5e7d2ef
https://doi.org/10.1371/journal.pcbi.1007777

Understanding the Nonlinear Dynamics of Driven Particles in Supercooled Liquids in Terms of an Effective Temperature

Autor: Andreas Heuer, Carsten F. E. Schroer

In active microrheology, the mechanical properties of a material are tested by adding probe particles which are pulled by an external force. In case of supercooled liquids, strong forcing leads to a thinning of the host material which becomes more pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714f1b3998d7f8317718c4f95012fb9b