Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Carsten C, Scholz"'
Autor:
Amalia Ruiz-Serrano, Christina N. Boyle, Josep M. Monné Rodríguez, Julia Günter, Agnieszka E. Jucht, Svende Pfundstein, Andreas M. Bapst, Thomas A. Lutz, Roland H. Wenger, Carsten C. Scholz
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1536 (2022)
Dysregulated energy metabolism is a major contributor to a multitude of pathologies, including obesity and diabetes. Understanding the regulation of metabolic homeostasis is of utmost importance for the identification of therapeutic targets for the t
Externí odkaz:
https://doaj.org/article/c316b0ce60bd44718fa2ef25c687347e
Autor:
Christina Pickel, Julia Günter, Amalia Ruiz-Serrano, Patrick Spielmann, Jacqueline-Alba Fabrizio, Witold Wolski, Daniel J. Peet, Roland H. Wenger, Carsten C. Scholz
Publikováno v:
Redox Biology, Vol 26, Iss , Pp - (2019)
Protein:protein interactions are the basis of molecular communication and are usually of transient non-covalent nature, while covalent interactions other than ubiquitination are rare. For cellular adaptations, the cellular oxygen and peroxide sensor
Externí odkaz:
https://doaj.org/article/00365a8b1c5646a184b02125553c807c
Autor:
Anna Faivre, Romain Dissard, Willy Kuo, Thomas Verissimo, David Legouis, Grégoire Arnoux, Carolyn Heckenmeyer, Marylise Fernandez, Matthieu Tihy, Renuga D Rajaram, Vasiliki Delitsikou, Ngoc An Le, Bernhard Spingler, Bert Mueller, Georg Shulz, Maja Lindenmeyer, Clemens Cohen, Joseph M Rutkowski, Solange Moll, Carsten C Scholz, Vartan Kurtcuoglu, Sophie de Seigneux
Publikováno v:
Nephrology Dialysis Transplantation.
Background The roles of hypoxia and hypoxia inducible factor (HIF) during chronic kidney disease (CKD) are much debated. Interventional studies with HIF-α activation in rodents yielded contradictory results. The HIF pathway is regulated by prolyl an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71dd5b611adc7bc17dbd22ae74372aa5
https://doi.org/10.1093/ndt/gfad075
https://doi.org/10.1093/ndt/gfad075
Autor:
Cormac T, Taylor, Carsten C, Scholz
Publikováno v:
Nature reviews. Nephrology. 18(9)
Cellular hypoxia occurs when the demand for sufficient molecular oxygen needed to produce the levels of ATP required to perform physiological functions exceeds the vascular supply, thereby leading to a state of oxygen depletion with the associated ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::06b9dea511bff8ddbbe4c6ffedd41351
https://pubmed.ncbi.nlm.nih.gov/35726016
https://pubmed.ncbi.nlm.nih.gov/35726016
Autor:
Carsten C Scholz, Javier Rodriguez, Christina Pickel, Stephen Burr, Jacqueline-Alba Fabrizio, Karen A Nolan, Patrick Spielmann, Miguel A S Cavadas, Bianca Crifo, Doug N Halligan, James A Nathan, Daniel J Peet, Roland H Wenger, Alex Von Kriegsheim, Eoin P Cummins, Cormac T Taylor
Publikováno v:
PLoS Biology, Vol 14, Iss 1, p e1002347 (2016)
The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a g
Externí odkaz:
https://doaj.org/article/195eb6b4e4534a8d981fea77cbdb36dd
Publikováno v:
Antioxidantsredox signaling. 37(13-15)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8434a8ae5635c5c4ef251c4592c05109
https://pubmed.ncbi.nlm.nih.gov/35166119
https://pubmed.ncbi.nlm.nih.gov/35166119
Publikováno v:
Pflugers Archiv : European journal of physiology. 474(8)
Renal erythropoietin (Epo)-producing (REP) cells represent a rare and incompletely understood cell type. REP cells are fibroblast-like cells located in close proximity to blood vessels and tubules of the corticomedullary border region. Epo mRNA in RE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b1877c79b24c7a078258b14908c605
https://pubmed.ncbi.nlm.nih.gov/35750861
https://pubmed.ncbi.nlm.nih.gov/35750861
Autor:
Roland H. Wenger, Samantha P M Sherman, Julia Günter, Agnieszka E Jucht, Josep M Monné Rodríguez, Carsten A. Wagner, Giovanni Pellegrini, Amalia Ruiz-Serrano, Yulia L Volkova, Pascal Fluechter, Svende Pfundstein, Carsten C. Scholz, Christoph Schneider
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(12)
OTUB1 is one of the most highly expressed deubiquitinases, counter-regulating the two most abundant ubiquitin chain types. OTUB1 expression is linked to the development and progression of lung cancer and idiopathic pulmonary fibrosis in humans. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdf259b862f46d6be9d274916d01735
https://pubmed.ncbi.nlm.nih.gov/34793600
https://pubmed.ncbi.nlm.nih.gov/34793600
Autor:
Sophie L. Dahl, Svende Pfundstein, Rico Hunkeler, Xingtong Dong, Thomas Knöpfel, Patrick Spielmann, Carsten C. Scholz, Karen A. Nolan, Roland H. Wenger
Publikováno v:
Acta physiologica (Oxford, England). 234(3)
Fibroblast-like renal erythropoietin (Epo) producing (REP) cells of the corticomedullary border region "sense" a decrease in blood oxygen content following anaemia or hypoxaemia. Burst-like transcription of Epo during tissue hypoxia is transient and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fac2c2e2ff7253940d7bdc25005923a
https://pubmed.ncbi.nlm.nih.gov/35000267
https://pubmed.ncbi.nlm.nih.gov/35000267
Publikováno v:
Journal of photochemistry and photobiology. B, Biology. 210
The three hypoxia-inducible factor (HIF) prolyl-4-hydroxylase domain (PHD) 1–3 enzymes confer oxygen sensitivity to the HIF pathway and are novel therapeutic targets for treatment of renal anemia. Inhibition of the PHDs may further be beneficial in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9363ec8d2abea68eca21f80154cccff1
https://pubmed.ncbi.nlm.nih.gov/32745950
https://pubmed.ncbi.nlm.nih.gov/32745950