356-P: Population Pharmacokinetic Modeling of Dasiglucagon in Subjects with Type 1 Diabetes Mellitus

Autor: Stine Just Maarbjerg, Paul M. Diderichsen, Han Witjes, Anders H. Valeur, Carsten Boye Knudsen, Ramin Tehranchi

Publikováno v: Diabetes. 70

To quantify the impact of subject covariates on pharmacokinetics (PK) of the novel, ready-to-use glucagon analog dasiglucagon, we developed a population PK model. Dasiglucagon pharmacokinetics was dose linear in the tested dose range (0.1 to 1.0 mg)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86391907f0bad0432f849dce5147c0c1
https://doi.org/10.2337/db21-356-p

Model of the Glucose-Insulin-Glucagon Dynamics after Subcutaneous Administration of a Glucagon Rescue Bolus in Healthy Humans

Autor: Sabrina Lyngbye Wendt, Jan Kloppenborg Møller, Ahmad Haidar, Britta Væver Bysted, Carsten Boye Knudsen, Henrik Madsen, John Bagterp Jørgensen

Publikováno v: Wendt, S L, Møller, J K, Haidar, A, Bysted, B V, Knudsen, C B, Madsen, H & Jørgensen, J B 2016, ' Model of the Glucose-Insulin-Glucagon Dynamics after Subcutaneous Administration of a Glucagon Rescue Bolus in Healthy Humans ' The American Diabetes Association's 76th Scientific Sessions (ADA 2016), New Orleans, Louisiana, United States, 10/06/2016-14/06/2016, .
Technical University of Denmark Orbit

In healthy individuals, insulin and glucagon work in a complex fashion to maintain blood glucose levels within a narrow range. This regulation is distorted in patients with diabetes. The hepatic glucose response due to an elevated glucagon level depe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b70c8a486d78bc36fddeba828a32a812
http://orbit.dtu.dk/ws/files/124207434/abstract_ada16_slw_final.pdf

Detection of Metallothionein Isoforms from Three Different Species Using On-Line Capillary Electrophoresis–Mass Spectrometry

Autor: Ole Jøns, Carsten Boye Knudsen, Steen Honoré Hansen, Inga Bjørnsdottir

Publikováno v: Analytical Biochemistry. 265:167-175

An on-line capillary electrophoresis–mass spectrometry method (CE–MS) for the detection of metallothionein (MT) isoforms is described. The detected masses were usually within 1–1.5 mass units of the expected molecular weights. MT-containing sam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3a6b2d59b13c87849dc6435cfeac17
https://doi.org/10.1006/abio.1998.2874

P-116: Physical fitness, body composition and intraabdominal fat: Relation to insulin resistance and insulin secretion in relatives of patients with NIDDM

Autor: Steen Mencke, Henning Beck-Nielsen, Hans Jørgen Gjessing, Klaus Levin, Carsten Boye Knudsen, Peter Thye-Rønn

Publikováno v: Experimental and Clinical Endocrinology & Diabetes. 104:178-179

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d38094730700caa0b7f988609260cfd4
https://doi.org/10.1055/s-0029-1211660

Modelling the glucose-insulin-glucagon dynamics after subcutaneous administration of native glucagon and a novel glucagon analogue in dogs

Autor: Sabrina Lyngbye Wendt, Carsten Boye Knudsen, John Bagterp Jørgensen, Henrik Madsen, Ahmad Haidar

Publikováno v: Technical University of Denmark Orbit
Wendt, S L, Boye Knudsen, C, Jørgensen, J B, Madsen, H & Haidar, A 2016, ' Modelling the glucose-insulin-glucagon dynamics after subcutaneous administration of native glucagon and a novel glucagon analogue in dogs ' 9th International Conference on Advanced Technol​ogies and Treatments for Diabetes (ATTD 2016), Milan, Italy, 03/02/2016-06/02/2016, .

Zealand Pharma has invented a glucagon analogue, ZP-GA-1, with increased stability in liquid formulation for treatment of hypoglycemia. A pharmacodynamic (PD) model is needed to compare ZP-GA-1 with marketed glucagon. We aim to develop a model of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::015258276fbc14d06d53bf796289d70d
https://orbit.dtu.dk/en/publications/53d1edd3-8bc6-4d8d-af0a-3fb68eed5658