Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Carsten, Wrenger"'
Autor:
Yasmin Silva-Santos, Roberta Liberato Pagni, Thais Helena Martins Gamon, Marcela Santiago Pacheco de Azevedo, Mônica Bielavsky, Maria Laura Goussain Darido, Danielle Bruna Leal de Oliveira, Edmarcia Elisa de Souza, Carsten Wrenger, Edson Luiz Durigon, Maria Cecília Rui Luvizotto, Hans Christian Ackerman, Claudio Romero Farias Marinho, Sabrina Epiphanio, Leonardo José Moura Carvalho
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
COVID-19 causes more severe and frequently fatal disease in patients with pre-existing comorbidities such as hypertension and heart disease. SARS-CoV-2 virus enters host cells through the angiotensin-converting enzyme 2 (ACE2), which is fundamental i
Externí odkaz:
https://doaj.org/article/0a80208c429c4258b038df8565cf4881
Autor:
Maurício T. Tavares, Arne Krüger, Sun L. Rei Yan, Karoline B. Waitman, Vinícius M. Gomes, Daffiny Sumam de Oliveira, Franciarli Paz, Sebastian Hilscher, Mike Schutkowski, Wolfgang Sippl, Claudia Ruiz, Mônica F. Z. J. Toledo, Neuza M. A. Hassimotto, João A. Machado-Neto, Antti Poso, Michael D. Cameron, Thomas D. Bannister, Giuseppe Palmisano, Carsten Wrenger, Thales Kronenberger, Roberto Parise-Filho
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract We report a series of 1,3-diphenylureido hydroxamate HDAC inhibitors evaluated against sensitive and drug-resistant P. falciparum strains. Compounds 8a–d show potent antiplasmodial activity, indicating that a phenyl spacer allows improved
Externí odkaz:
https://doaj.org/article/661e63afc62b4a918f5086fa3323ea43
Autor:
Luisa Fernanda Ortega Sepulveda, Gabriela Mendes de Oliveira, Elaine Hellen Nunes Chagas, Nele Wild, Franciarli Silva da Paz, Carsten Wrenger, Gerhard Wunderlich
Publikováno v:
Future Pharmacology, Vol 3, Iss 4, Pp 846-861 (2023)
The complex life cycle of the malaria parasite Plasmodium requires the parasite to adequately adapt to different conditions. For this reason, Plasmodium strictly controls its gene expression, and given its evolutionary distance from the human host, t
Externí odkaz:
https://doaj.org/article/f6939caaf97c43e19f0a5075a1d12393
Autor:
Patrick Y. A. Reinke, Edmarcia Elisa de Souza, Sebastian Günther, Sven Falke, Julia Lieske, Wiebke Ewert, Jure Loboda, Alexander Herrmann, Aida Rahmani Mashhour, Katarina Karničar, Aleksandra Usenik, Nataša Lindič, Andreja Sekirnik, Viviane Fongaro Botosso, Gláucia Maria Machado Santelli, Josana Kapronezai, Marcelo Valdemir de Araújo, Taiana Tainá Silva-Pereira, Antônio Francisco de Souza Filho, Mariana Silva Tavares, Lizdany Flórez-Álvarez, Danielle Bruna Leal de Oliveira, Edison Luiz Durigon, Paula Roberta Giaretta, Marcos Bryan Heinemann, Maurice Hauser, Brandon Seychell, Hendrik Böhler, Wioletta Rut, Marcin Drag, Tobias Beck, Russell Cox, Henry N. Chapman, Christian Betzel, Wolfgang Brehm, Winfried Hinrichs, Gregor Ebert, Sharissa L. Latham, Ana Marcia de Sá Guimarães, Dusan Turk, Carsten Wrenger, Alke Meents
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro inhibition assays hints at a second target. Indeed, we s
Externí odkaz:
https://doaj.org/article/959ee7d783844cc0965882267049dc4f
Autor:
Mariângela de Oliveira Silva, Maria Fernanda Castro-Amarante, Alexia Adrianne Venceslau-Carvalho, Bianca da Silva Almeida, Isabela Pazotti Daher, Guilherme Antonio de Souza-Silva, Marcio Massao Yamamoto, Gabriela Koike, Edmarcia Elisa de Souza, Carsten Wrenger, Luís Carlos de Souza Ferreira, Silvia Beatriz Boscardin
Publikováno v:
Vaccines, Vol 12, Iss 4, p 356 (2024)
The unprecedented global impact caused by SARS-CoV-2 imposed huge health and economic challenges, highlighting the urgent need for safe and effective vaccines. The receptor-binding domain (RBD) of SARS-CoV-2 is the major target for neutralizing antib
Externí odkaz:
https://doaj.org/article/b18e25fb932b4d27913f21f4859b0530
Autor:
Vasundara Srinivasan, Hévila Brognaro, Prince R. Prabhu, Edmarcia Elisa de Souza, Sebastian Günther, Patrick Y. A. Reinke, Thomas J. Lane, Helen Ginn, Huijong Han, Wiebke Ewert, Janina Sprenger, Faisal H. M. Koua, Sven Falke, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Bruno Alves Franca, Mengying Wang, Angélica Luana C. Barra, Markus Perbandt, Martin Schwinzer, Christina Schmidt, Lea Brings, Kristina Lorenzen, Robin Schubert, Rafael Rahal Guaragna Machado, Erika Donizette Candido, Danielle Bruna Leal Oliveira, Edison Luiz Durigon, Stephan Niebling, Angelica Struve Garcia, Oleksandr Yefanov, Julia Lieske, Luca Gelisio, Martin Domaracky, Philipp Middendorf, Michael Groessler, Fabian Trost, Marina Galchenkova, Aida Rahmani Mashhour, Sofiane Saouane, Johanna Hakanpää, Markus Wolf, Maria Garcia Alai, Dusan Turk, Arwen R. Pearson, Henry N. Chapman, Winfried Hinrichs, Carsten Wrenger, Alke Meents, Christian Betzel
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Three natural phenolic compounds are found to bind to an allosteric site in SARS-CoV-2 papain-like protease and exhibit antiviral activity in vitro, showing potential as starting scaffolds for drug design.
Externí odkaz:
https://doaj.org/article/94a6b8437953446b80663a578e6c235a
Autor:
Aline Melro Murad, Hévila Brognaro, Sven Falke, Jasmin Lindner, Markus Perbandt, Celestin Mudogo, Robin Schubert, Carsten Wrenger, Christian Betzel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Humanity is facing an increasing health threat caused by a variety of multidrug resistant bacteria. Within this scenario, Staphylococcus aureus, in particular methicillin resistant S. aureus (MRSA), is responsible for a number of hospital-ac
Externí odkaz:
https://doaj.org/article/3e25d1c42ea54569ba4278da4c2a3819
Autor:
Lucas C. Lazari, Rodrigo M. Zerbinati, Livia Rosa-Fernandes, Veronica Feijoli Santiago, Klaise F. Rosa, Claudia B. Angeli, Gabriela Schwab, Michelle Palmieri, Dmitry J. S. Sarmento, Claudio R. F. Marinho, Janete Dias Almeida, Kelvin To, Simone Giannecchini, Carsten Wrenger, Ester C. Sabino, Herculano Martinho, José A. L. Lindoso, Edison L. Durigon, Paulo H. Braz-Silva, Giuseppe Palmisano
Publikováno v:
Journal of Oral Microbiology, Vol 14, Iss 1 (2022)
Background The SARS-CoV-2 infections are still imposing a great public health challenge despite the recent developments in vaccines and therapy. Searching for diagnostic and prognostic methods that are fast, low-cost and accurate are essential for di
Externí odkaz:
https://doaj.org/article/0602c9cb7ef747f5a112678c88da6568
Autor:
Lizdany Flórez-Álvarez, Edmarcia Elisa de Souza, Viviane Fongaro Botosso, Danielle Bruna Leal de Oliveira, Paulo Lee Ho, Carlos Pelleschi Taborda, Giuseppe Palmisano, Margareth Lara Capurro, João Renato Rebello Pinho, Helena Lage Ferreira, Paola Minoprio, Eurico Arruda, Luís Carlos de Souza Ferreira, Carsten Wrenger, Edison Luiz Durigon
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Hemorrhagic fever viruses (HFVs) pose a threat to global public health owing to the emergence and re-emergence of highly fatal diseases. Viral hemorrhagic fevers (VHFs) caused by these viruses are mostly characterized by an acute febrile syndrome wit
Externí odkaz:
https://doaj.org/article/22e4f97efec644c296da8bf0aae66662
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1638 (2023)
Malaria kills more than 500,000 people yearly, mainly affecting Africa and Southeast Asia. The disease is caused by the protozoan parasite from the genus Plasmodium, with Plasmodium vivax and Plasmodium falciparum being the main species that cause th
Externí odkaz:
https://doaj.org/article/85b636b592e940ccb9baacb86344adcf