Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Carsten, Schwaenen"'
Autor:
Henry Loeffler-Wirth, Markus Kreuz, Lydia Hopp, Arsen Arakelyan, Andrea Haake, Sergio B. Cogliatti, Alfred C. Feller, Martin-Leo Hansmann, Dido Lenze, Peter Möller, Hans Konrad Müller-Hermelink, Erik Fortenbacher, Edith Willscher, German Ott, Andreas Rosenwald, Christiane Pott, Carsten Schwaenen, Heiko Trautmann, Swen Wessendorf, Harald Stein, Monika Szczepanowski, Lorenz Trümper, Michael Hummel, Wolfram Klapper, Reiner Siebert, Markus Loeffler, Hans Binder, for the German Cancer Aid consortium Molecular Mechanisms for Malignant Lymphoma
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-20 (2019)
Abstract Background Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic phenotypes of this disease based on 873 biopsy
Externí odkaz:
https://doaj.org/article/eb092f16cead48828dfcb25f4bc14f5e
Autor:
Peter Lichter, Bernhard Radlwimmer, Hans-Peter Sinn, Martin Bentz, Björn Fritz, Swen Wessendorf, Gunnar Wrobel, Peter Roerig, Carsten Schwaenen, Karsten Richter, Michelle Nessling
Complete set of CGH results of advanced breast cancer in 31 tumor cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09cff243c2cde6ad8cca57ac1582ffb
https://doi.org/10.1158/0008-5472.22361676.v1
https://doi.org/10.1158/0008-5472.22361676.v1
Autor:
Peter Lichter, Bernhard Radlwimmer, Hans-Peter Sinn, Martin Bentz, Björn Fritz, Swen Wessendorf, Gunnar Wrobel, Peter Roerig, Carsten Schwaenen, Karsten Richter, Michelle Nessling
Genomic imbalances in 31 formalin-fixed and paraffin-embedded primary tumors of advanced breast cancer were analyzed by microarray-based comparative genomic hybridization (matrix-CGH). A DNA chip was designed comprising 422 mapped genomic sequences i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9275354f0a72c08bd1594a559fb14c46
https://doi.org/10.1158/0008-5472.c.6493065.v1
https://doi.org/10.1158/0008-5472.c.6493065.v1
Autor:
Richard F. Schlenk, Gesine Bug, Decider Study Team, Arnold Ganser, Wolfram Brugger, Helmut R. Salih, Claudia Schmoor, Hans-Walter Lindemann, Ralph Wäsch, Michael Lübbert, Konstanze Döhner, Olga Grishina, Carsten Schwaenen, Michael Heuser, Andreas Neubauer, Katharina Götze, Ulrich Germing, Marcus M Schittenhelm, Justus Duyster, Gerhard Heil, Andrea Kuendgen, Aristoteles Giagounidis, Martina Crysandt, Hartmut Döhner, Björn Hackanson, Felicitas Thol, Edgar Jost, Jürgen Krauter, Maike de Wit, Annette M. May, Sebastian Scholl, Heiko Becker, Carsten Müller-Tidow
Publikováno v:
Journal of Clinical Oncology. 38:257-270
PURPOSE DNA-hypomethylating agents are studied in combination with other epigenetic drugs, such as histone deacetylase inhibitors or differentiation inducers (eg, retinoids), in myeloid neoplasias. A randomized, phase II trial with a 2 × 2 factorial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706c55887c4e7f36469f84e45fb0c3a1
https://doi.org/10.1200/jco.19.01053
https://doi.org/10.1200/jco.19.01053
Autor:
Sietse M. Aukema, Markus Kreuz, Christian W Kohler, Maciej Rosolowski, Dirk Hasenclever, Michael Hummel, Ralf Küppers, Dido Lenze, German Ott, Christiane Pott, Julia Richter, Andreas Rosenwald, Monika Szczepanowski, Carsten Schwaenen, Harald Stein, Heiko Trautmann, Swen Wessendorf, Lorenz Trümper, Markus Loeffler, Rainer Spang, Philip M. Kluin, Wolfram Klapper, Reiner Siebert
Publikováno v:
Haematologica, Vol 99, Iss 4 (2014)
Chromosomal translocations affecting the MYC oncogene are the biological hallmark of Burkitt lymphomas but also occur in a subset of other mature B-cell lymphomas. If accompanied by a chromosomal break targeting the BCL2 and/or BCL6 oncogene these MY
Externí odkaz:
https://doaj.org/article/8ade27f09fd947668de3641b424b15ba
Autor:
René Scholtysik, Markus Kreuz, Wolfram Klapper, Birgit Burkhardt, Alfred C. Feller, Michael Hummel, Markus Loeffler, Maciej Rosolowski, Carsten Schwaenen, Rainer Spang, Harald Stein, Christoph Thorns, Lorenz Trümper, Inga Vater, Swen Wessendorf, Thorsten Zenz, Reiner Siebert, Ralf Küppers
Publikováno v:
Haematologica, Vol 95, Iss 12 (2010)
Background Knowledge about the genetic lesions that occur in Burkitt’s lymphoma, besides the pathognomonic IG-MYC translocations, is limited.Design and Methods Thirty-nine molecularly-defined Burkitt’s lymphomas were analyzed with high-resolution
Externí odkaz:
https://doaj.org/article/42a9a6fe053a46fa8803a070ee179cdd
Autor:
Judith Dierlamm, Eva M. Murga Penas, Stefan Bentink, Swen Wessendorf, Hilmar Berger, Michael Hummel, Wolfram Klapper, Dido Lenze, Andreas Rosenwald, Eugenia Haralambieva, German Ott, Sergio B. Cogliatti, Peter Möller, Carsten Schwaenen, Harald Stein, Markus Löffler, Rainer Spang, Lorenz Trümper, Reiner Siebert, for the Deutsche Krebshilfe Network Project “Molecular Mechanisms in Malignant Lymphomas”
Publikováno v:
Haematologica, Vol 93, Iss 5 (2008)
Background The aim of this study was to determine the impact of a gain of the MALT1 gene on gene expression and clinical parameters in diffuse large B-cell lymphoma.Design and Methods We analyzed 116 cases of diffuse large B-cell lymphoma by fluoresc
Externí odkaz:
https://doaj.org/article/759243d0bc724d34b219c38f3f8123d8
Autor:
Ralph Wäsch, Richard F. Schlenk, Heiko Becker, Katharina Goetze, Sebastian Scholl, Carsten Schwaenen, Carsten Müller-Tidow, Dennis Zimmer, Hartmut Döhner, Aristoteles Giagounidis, Andreas Neubauer, Michael Lübbert, Edgar Jost, Martina Crysandt, Gerhard Heil, Annette M. May, Björn Hackanson, Felicitas Thol, Ulrich Germing, Claudia Schmoor, Michael Heuser, Helmut R. Salih, Justus Duyster, Marcus M. Schittenhelm, Jürgen Krauter, Konstanze Döhner, Maike de Wit, Andrea Kündgen, Gesine Bug, Dietmar Pfeifer, Arnold Ganser, Wolfram Brugger, Olga Grishina
Publikováno v:
Blood. 138:2380-2380
Background TP53 mutations are associated with adverse outcome of AML treated with cytarabine-based regimens. Interestingly, DNA-hypomethylating agents (HMAs) induce a higher response rate in TP53-mutated (MUT) compared to TP53 wildtype (WT) AML (Welc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afeb5fab31fd2696d8fc04ec279484f0
https://doi.org/10.1182/blood-2021-146468
https://doi.org/10.1182/blood-2021-146468
Autor:
Ulrich Germing, Andreas Neubauer, Carsten Mueller-Tidow, Justus Duyster, Aristoteles Giagounidis, Gerhard Heil, Claudia Schmoor, Björn Hackanson, Felicitas Thol, Sebastian Scholl, Hartmut Döhner, Ralph Wäsch, Jürgen Krauter, Carsten Schwaenen, Annette M. May, Maike de Wit, Richard F. Schlenk, Andrea Kündgen, Christoph Rummelt, Gesine Bug, Martina Crysandt, Michael Luebbert, Konstanze Döhner, Heiko Becker, Michael Heuser, Stephan Kremers, Marcus M. Schittenhelm, Arnold Ganser, Wolfram Brugger, Helmut R. Salih, Edgar Jost, Olga Grishina, Katharina Götze
Publikováno v:
Blood. 136:9-10
Background: DNA-hypomethylating agents are providing a very well-accepted backbone for non-intensive combination treatment of AML/MDS patients (pts), and an in vivo synergism has been demonstrated for the azacitidine+venetoclax combination in the VIA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d606f77db50a96ea78a45008cc77c9e
https://doi.org/10.1182/blood-2020-140664
https://doi.org/10.1182/blood-2020-140664
Autor:
Henry Loeffler-Wirth, Markus Kreuz, Lydia Hopp, Arsen Arakelyan, Andrea Haake, Sergio B. Cogliatti, Alfred C. Feller, Martin-Leo Hansmann, Dido Lenze, Peter Möller, Hans Konrad Müller-Hermelink, Erik Fortenbacher, Edith Willscher, German Ott, Andreas Rosenwald, Christiane Pott, Carsten Schwaenen, Heiko Trautmann, Swen Wessendorf, Harald Stein, Monika Szczepanowski, Lorenz Trümper, Michael Hummel, Wolfram Klapper, Reiner Siebert, Markus Loeffler, Hans Binder, for the German Cancer Aid consortium Molecular Mechanisms for Malignant Lymphoma
Publikováno v:
Genome Medicine
Genome Medicine, Vol 11, Iss 1, Pp 1-20 (2019)
Genome Medicine, Vol 11, Iss 1, Pp 1-20 (2019)
Background Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic phenotypes of this disease based on 873 biopsy specimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae96b6c68c09c593529b722e06e3b3b8
https://pubmed.ncbi.nlm.nih.gov/31039827
https://pubmed.ncbi.nlm.nih.gov/31039827