Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Carsten, Schmitz"'
Autor:
Jonathan I. Silverberg, David Rosmarin, Raj Chovatiya, Thomas Bieber, Stephen Schleicher, Lisa Beck, Melinda Gooderham, Sohail Chaudhry, Christie Fanton, Danni Yu, Joshua Levy, Yi Liu, Takahiro Miyazaki, Mary Tagliaferri, Carsten Schmitz, Ajay Nirula, Brian Kotzin, Jonathan Zalevsky
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Regulatory T cell (Treg) impairment is implicated in the pathogenesis of chronic inflammatory diseases, but relatively little is known about the therapeutic potential of Treg restoration. Here we present clinical evidence for the Treg-select
Externí odkaz:
https://doaj.org/article/9bc93354dab940bc992d2c583c1fb98c
Autor:
Lewin Small, Tuong-Vi Nguyen, Mark Larance, Darren N. Saunders, Andrew J. Hoy, Carsten Schmitz-Peiffer, Gregory J. Cooney, Amanda E. Brandon
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 12, Pp 100687- (2024)
De novo lipogenesis (DNL) has been implicated in the development and progression of liver steatosis. Hepatic DNL is strongly influenced by dietary macronutrient composition with diets high in carbohydrate increasing DNL while diets high in fat decrea
Externí odkaz:
https://doaj.org/article/513ef43f4b65474785efe0648ea8f204
Autor:
Le May Thai, Liam O’Reilly, Saskia Reibe-Pal, Nancy Sue, Holly Holliday, Lewin Small, Carsten Schmitz-Peiffer, Rama Dhenni, Vicky Wang-Wei Tsai, Nicholas Norris, Belinda Yau, Xuan Zhang, Kailun Lee, Chenxu Yan, Yan-Chuan Shi, Melkam A. Kebede, Robert Brink, Gregory J. Cooney, Katharine M. Irvine, Samuel N. Breit, Tri G. Phan, Alexander Swarbrick, Trevor J. Biden
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106477- (2023)
Summary: We have exploited islet-associated macrophages (IAMs) as a model of resident macrophage function, focusing on more physiological conditions than the commonly used extremes of M1 (inflammation) versus M2 (tissue remodeling) polarization. Unde
Externí odkaz:
https://doaj.org/article/f164ff5bf0454edab4a24997c1c6486a
Autor:
Nigel Turner, Xin Ying Lim, Hamish D. Toop, Brenna Osborne, Amanda E. Brandon, Elysha N. Taylor, Corrine E. Fiveash, Hemna Govindaraju, Jonathan D. Teo, Holly P. McEwen, Timothy A. Couttas, Stephen M. Butler, Abhirup Das, Greg M. Kowalski, Clinton R. Bruce, Kyle L. Hoehn, Thomas Fath, Carsten Schmitz-Peiffer, Gregory J. Cooney, Magdalene K. Montgomery, Jonathan C. Morris, Anthony S. Don
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Ceramides are signalling molecules that regulate several physiological functions including insulin sensitivity. Here the authors report a selective ceramide synthase 1 inhibitor that counteracts lipid accumulation within the muscle and adiposity by i
Externí odkaz:
https://doaj.org/article/b889316af6b04ac29b1836b3ff8bcb97
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178021 (2017)
Cigarette smoking is the primary cause of chronic obstructive pulmonary disease (COPD) with repeated and sustained infections linked to disease pathogenesis and exacerbations. The airway epithelium constitutes the first line of host defense against i
Externí odkaz:
https://doaj.org/article/49c0262af65646719ddbe685492b1ce3
Autor:
Carsten Schmitz-Peiffer
Publikováno v:
Trends in Endocrinology & Metabolism. 31:344-356
The failure of insulin to suppress glucose production by the liver is a key aspect of the insulin resistance seen in type 2 diabetes. Lipid-activated protein kinase C epsilon has long been identified as an important mediator of diet-induced glucose i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d1c6af2549c0d1ac09e8cbdc85d675
https://doi.org/10.1016/j.tem.2020.01.016
https://doi.org/10.1016/j.tem.2020.01.016
Autor:
Siiri E Iismaa, Mark Aplin, Sara Holman, Ting W Yiu, Kristy Jackson, James G Burchfield, Christopher J Mitchell, Liam O'Reilly, Aimee Davenport, James Cantley, Carsten Schmitz-Peiffer, Trevor J Biden, Gregory J Cooney, Robert M Graham
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63346 (2013)
Transglutaminase type 2 (TG2) has been reported to be a candidate gene for maturity onset diabetes of the young (MODY) because three different mutations that impair TG2 transamidase activity have been found in 3 families with MODY. TG2 null (TG2(-/-)
Externí odkaz:
https://doaj.org/article/c5373c97cc8e46da9b4c6f18dc20127c
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58046 (2013)
We have previously shown that deletion of protein kinase C epsilon (PKCε) in mice results in protection against glucose intolerance caused by a high fat diet. This was in part due to reduced insulin uptake by hepatocytes and insulin clearance, which
Externí odkaz:
https://doaj.org/article/9d13435dfa57486f8c4b043e0554a9df
Autor:
Kyle L. Hoehn, Corrine E. Fiveash, Greg M. Kowalski, Jonathan D. Teo, Carsten Schmitz-Peiffer, Timothy A. Couttas, Hemna Govindaraju, Magdalene K. Montgomery, Gregory J. Cooney, Amanda E. Brandon, Anthony S. Don, Brenna Osborne, Jonathan C. Morris, Nigel Turner, Abhirup Das, Holly P. McEwen, Thomas Fath, Hamish D. Toop, Elysha N. Taylor, Xin Ying Lim, Clinton R. Bruce, Stephen M. Butler
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Specific forms of the lipid ceramide, synthesized by the ceramide synthase enzyme family, are believed to regulate metabolic physiology. Genetic mouse models have established C16 ceramide as a driver of insulin resistance in liver and adipose tissue.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f84651f9b80228fd1455082d01ad44f
http://link.springer.com/article/10.1038/s41467-018-05613-7
http://link.springer.com/article/10.1038/s41467-018-05613-7
Publikováno v:
Cellular and Molecular Life Sciences. 75:3069-3078
The Melastatin-related Transient Receptor Potential member 7 (TRPM7) is a unique fusion protein with both ion channel function and enzymatic α-kinase activity. TRPM7 is essential for cellular systemic magnesium homeostasis and early embryogenesis, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51a690798c597932cda1e00bc079532
https://doi.org/10.1007/s00018-018-2786-z
https://doi.org/10.1007/s00018-018-2786-z