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pro vyhledávání: '"Carson V, Dobrin"'
Publikováno v:
Psychopharmacology. 225:935-944
It has long been observed that rats self-administer psychostimulants in a highly regular pattern. The inverse relationship between dose and rate of drug intake has been interpreted as a titration phenomenon wherein brain-cocaine levels are maintained
Autor:
Carson V, Dobrin, David C S, Roberts
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 829
A discrete trials procedure involves splitting up a self-administration session so that there are multiple distinct trials and inter-trial-intervals. This schedule is well suited to be used over 24 h periods which allows insight into diurnal variabil
Autor:
David C.S. Roberts, Carson V. Dobrin
Publikováno v:
Methods in Molecular Biology ISBN: 9781617794575
A discrete trials procedure involves splitting up a self-administration session so that there are multiple distinct trials and inter-trial-intervals. This schedule is well suited to be used over 24 h periods which allows insight into diurnal variabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::414795db3a6f32a85546add5a1d53417
https://doi.org/10.1007/978-1-61779-458-2_19
https://doi.org/10.1007/978-1-61779-458-2_19
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 36(13)
A novel behaviorally dependent dosing (BDD) schedule was used to examine the relationship between doses of cocaine self-administered by rats and brain drug levels within a session. The BDD schedule used a hold-down response to activate a syringe pump