Transcriptional synergy in human aortic endothelial cells is vulnerable to combination p300/CBP and BET bromodomain inhibition.

Autor: Bracken RC; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Davison LM; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Buehler DP; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Fulton ME; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Carson EE; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Sheng Q; Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 3723, USA., Stolze LK; Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 3723, USA., Guillermier C; Harvard Medical School, Boston, MA 02115, USA.; Center for NanoImaging, Cambridge MA 02115, USA.; Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA., Steinhauser ML; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Brown JD; Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Publikováno v: IScience [iScience] 2024 May 16; Vol. 27 (6), pp. 110011. Date of Electronic Publication: 2024 May 16 (Print Publication: 2024).