Výsledky vyhledávání - "Carson C. Thoreen"

Akademický článek

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

Autor: Yeonwoo Park, Andrea Reyna-Neyra, Lucas Philippe, Carson C. Thoreen

Publikováno v: Cell Reports, Vol 19, Iss 6, Pp 1083-1090 (2017)

The mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that is commonly deregulated in human diseases. Here we find that mTORC1 controls a transcriptional program encoding amino acid transporters and metabolic enzym

Externí odkaz: https://doaj.org/article/459f6d7488c04317a580767ff625174c

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Akademický článek

mRNA 5' terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay.

Autor: Antonia M G van den Elzen, Maegan J Watson, Carson C Thoreen

Publikováno v: PLoS Genetics, Vol 18, Iss 11, p e1010532 (2022)

mRNA regulatory sequences control gene expression at multiple levels including translation initiation and mRNA decay. The 5' terminal sequences of mRNAs have unique regulatory potential because of their proximity to key post-transcriptional regulator

Externí odkaz: https://doaj.org/article/a42b665c59694137967f56ea25e39515

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Supplementary Figure S2 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP

Autor: Joan S. Brugge, Gordon B. Mills, David M. Sabatini, Seong A. Kang, Carson C. Thoreen, Jonathan L. Coloff, Lisa L. Gallegos, Julie Hwang, Laura M. Selfors, Taru Muranen

MYC and YAP expression mediate drug resistance towards PI3K/mTOR inhibition.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6feae362dc86fd38aae6250a27b80afe
https://doi.org/10.1158/0008-5472.22413065

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Supplementary Methods from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP

Autor: Joan S. Brugge, Gordon B. Mills, David M. Sabatini, Seong A. Kang, Carson C. Thoreen, Jonathan L. Coloff, Lisa L. Gallegos, Julie Hwang, Laura M. Selfors, Taru Muranen

Description of additional methods and procedures used in the study.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3808ddce8d6d44c713d7934c92448d11
https://doi.org/10.1158/0008-5472.22413059.v1

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Data from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP

Autor: Joan S. Brugge, Gordon B. Mills, David M. Sabatini, Seong A. Kang, Carson C. Thoreen, Jonathan L. Coloff, Lisa L. Gallegos, Julie Hwang, Laura M. Selfors, Taru Muranen

Aberrant activation of the PI3K/mTOR pathway is a common feature of many cancers and an attractive target for therapy, but resistance inevitably evolves as is the case for any cancer cell–targeted therapy. In animal tumor models, chronic inhibition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af17015adfd145fdb9c9aeb255f8420b
https://doi.org/10.1158/0008-5472.c.6508604.v1

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Supplementary Figure Legends from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP

Autor: Joan S. Brugge, Gordon B. Mills, David M. Sabatini, Seong A. Kang, Carson C. Thoreen, Jonathan L. Coloff, Lisa L. Gallegos, Julie Hwang, Laura M. Selfors, Taru Muranen

Legends for Supplementary Figures S1-S4.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730777e79a2142330409a6bdc826e7c3
https://doi.org/10.1158/0008-5472.22413071

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Supplementary Figures 1 - 4 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

PDF file - 719K, Supplemental figure 1. Torin2 on PC-3 wide type cell line, the IB was made after 30 min treatment of drug at indicated concentrations. Supplemental figure 2. Torin1, Torin2, AZD8055 and BEZ235 on HeLa and HCT-116 cell line at differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f1b766942775ec1d341f6520972504
https://doi.org/10.1158/0008-5472.22398726.v1

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Supplementary Table 1 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

PDF file - 401K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfd6389bcfe5cc37d8e136047ce9803
https://doi.org/10.1158/0008-5472.22398723.v1

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Supplementary Figure Legend and Tables 2 - 3 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

PDF file - 69K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b19dcaaff2b32304691f7dfcabff892
https://doi.org/10.1158/0008-5472.22398729

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Controversies around the function of LARP1

Autor: Andrea J. Berman, Zinaida Dedeic, Sarah P. Blagden, James Chettle, Carson C. Thoreen, Philippe P. Roux

Publikováno v: RNA Biology
article-version (VoR) Version of Record

The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation. Paradoxically, some scientists have shown that LARP1 represses TOP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1f7c47ca138788290af30583366b5b
http://europepmc.org/articles/PMC7928164

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