Zobrazeno 1 - 10
of 666
pro vyhledávání: '"Carroll Fi"'
Publikováno v:
Synthesis. 44:57-62
The orally active, noncompetitive, selective AMPA receptor antagonist Perampanel, 2-[1′,6′-dihydro-6′-oxo-1-phenyl-(2′,3′-bipyridin)-5′-yl]benzonitrile, has been prepared from readily available, relatively inexpensive starting materials.
Autor:
Carroll Fi, Lawrence Brieaddy
Publikováno v:
Synthetic Communications. 38:1926-1930
A practical synthesis of optically pure 1-[(3R,4R)-1-cyclooctylmethyl-3-ethoxycarbonyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) was developed that avoids the use of chiral columns.
Autor:
Runyon Sp, Carroll Fi
Publikováno v:
Current Topics in Medicinal Chemistry. 6:1825-1843
The dopamine transporter (DAT) is a target for the development of pharmacotherapies for a number of central disorders including Parkinson's disease, Alzheimer's disease, schizophrenia, Tourette's syndrome, Lesch-Nyhan disease, attention deficit hyper
Autor:
Carroll Fi, Jeffrey R. Deschamps, S. W. Mascarella, Bruce E. Blough, Zhe Nie, Xiaodong Huang, Hernán A. Navarro
Publikováno v:
Journal of Medicinal Chemistry. 49:4589-4594
A series of cyclo-3beta-(4-aminophenyl)-2beta-tropanemethanol analogues (5a-m) possessing varying linker groups between the 2- and 3-position on the tropane ring were synthesized and evaluated for their monoamine transporter binding properties. The r
Autor:
D. M. Zimmerman, S. W. Mascarella, Richard B. Rothman, Carroll Fi, Jim A. Thomas, B. E. Cantrell, Christina M. Dersch, Scott E. Fix
Publikováno v:
Journal of Medicinal Chemistry. 47:1070-1073
In vitro characterization and comparison of JDTic, its dehydroxy analogue and nor-BNI, and its dehydroxy analogue demonstrates that the N-substituted 3,4-dimethyl-(3-hydroxyphenyl)piperidine-derived antagonist, JDTic, relies more heavily on its pheno
Publikováno v:
Neuropharmacology. 39:578-585
Intracerebroventricular injections of the irreversible dopamine transporter (DAT) inhibitor, RTI-76 [3beta-(3-p-chlorophenyl) tropan-2beta-carboxylic acid p-isothiocyanatophenylethyl ester hydrochloride], decreased DAT binding in both the striatum an
RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter
Publikováno v:
Synapse. 30:49-55
RTI-113 [3β-(4-chlorophenyl)tropan-2β carboxylic acid phenyl ester hydrochloride], one of many phenyltropanes potent at and selective for DAT, inhibited self-administration of cocaine in rat at doses that did not alter responding maintained by food
Autor:
Chih Cheng Chien, Gavril W. Pasternak, Ying-Xian Pan, George P. Brown, Wayne D. Bowen, Carroll Fi
Publikováno v:
European Journal of Pharmacology. 321:361-368
Pentazocine is a potent ligand at both opioid and sigma receptors, but with opposite stereoselectivities. Whereas (-)-pentazocine has high affinity for a number of opioid receptors, (+)-pentazocine labels sigma 1 receptors. Iodination of (-)-pentazoc
The α7 nicotinic ACh receptor subtype is abundantly expressed in the CNS and in the periphery. Recent evidence suggests that α7 nicotinic ACh receptor (nAChR) subtypes, which can be activated by an endogenous cholinergic tone comprising ACh and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b79d1c8d0999818db3d7d0200545b9ba
https://europepmc.org/articles/PMC3682705/
https://europepmc.org/articles/PMC3682705/
Autor:
Carroll Fi, John W. Boja, Michael J. Kuhar, S. W. Mascarella, Anita H. Lewin, Philip Abraham, Pravin Kotian
Publikováno v:
Journal of Medicinal Chemistry. 39:2753-2763
A set of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes was designed, synthesized, and characterized. We discovered that these compounds can function as bioisosteric replacements for the corresponding WIN 35,065-2 analogs which possess a